[Term]
id: PR:O08852
name: polycystin-1 (mouse)
def: "A polycystin-1 that is encoded in the genome of mouse." [OMA:O08852, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pkd1" RELATED Gene-based [UniProtKB:O08852]
synonym: "mPKD1" EXACT PRO-short-label [PRO:DNx]
synonym: "autosomal dominant polycystic kidney disease 1 protein homolog (mouse)" EXACT [UniProtKB:O08852]
xref: UniProtKB:O08852
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000012769 ! polycystin-1
relationship: has_gene_template MGI:97603 ! Pkd1 (mouse)

[Term]
id: PR:P98161-3
name: polycystin-1 isoform h3 (human)
def: "A polycystin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98161-3." [PRO:DNx, UniProtKB:P98161]
comment: Category=organism-sequence.
synonym: "hPKD1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P98161-3
is_a: PR:P98161 ! polycystin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P98161-2
name: polycystin-1 isoform h2 (human)
def: "A polycystin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98161-2." [PRO:DNx, UniProtKB:P98161]
comment: Category=organism-sequence.
synonym: "hPKD1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P98161-2
is_a: PR:P98161 ! polycystin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P98161-1
name: polycystin-1 isoform h1 (human)
def: "A polycystin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98161-1." [PRO:DNx, UniProtKB:P98161]
comment: Category=organism-sequence.
synonym: "hPKD1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P98161-1
is_a: PR:P98161 ! polycystin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000012769
name: polycystin-1
def: "A protein that is a translation product of the human PKD1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PKD1" EXACT PRO-short-label [PRO:DNx]
synonym: "autosomal dominant polycystic kidney disease 1 protein" EXACT []
synonym: "autosomal dominant polycystic kidney disease 1 protein homolog" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000048782
name: polycystin-1, signal peptide removed form (human)
def: "A polycystin-1 (human) that has had the signal peptide removed. UniProtKB:P98161, 24-4303." [PRO:DNx, Reactome:R-HSA-5623390, Reactome:R-HSA-5623413, Reactome:R-HSA-5623414]
comment: Category=organism-modification.
synonym: "hPKD1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000024298" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P98161, 24-4303" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5623390 "PR:000048782 located_in GO:0000139"
xref: Reactome:R-HSA-5623413 "PR:000048782 located_in GO:0060170"
xref: Reactome:R-HSA-5623414 "PR:000048782 located_in GO:0030660"
intersection_of: PR:P98161 ! polycystin-1 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P98161
name: polycystin-1 (human)
def: "A polycystin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P98161]
comment: Category=organism-gene.
synonym: "PKD1" RELATED Gene-based [UniProtKB:P98161]
synonym: "hPKD1" EXACT PRO-short-label [PRO:DNx]
synonym: "PC1 (human)" BROAD [UniProtKB:P98161]
synonym: "autosomal dominant polycystic kidney disease 1 protein (human)" EXACT [UniProtKB:P98161]
xref: UniProtKB:P98161
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012769 ! polycystin-1
relationship: has_gene_template HGNC:9008 ! PKD1 (human)

[Term]
id: PR:000045862
name: polycystin-1 phosphorylated 1 (human)
def: "A polycystin-1 (human) that has been phosphorylated at the position equivalent to Tyr-4237 of the amino acid sequence represented by UniProtKB:P98161-1. Example: UniProtKB:P98161-1, Tyr-4237, MOD:00048." [PMID:21126580, iPTMnet:P98161]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21126580). Status=unreviewed.
synonym: "hPKD1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P98161-1, Tyr-4237, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P98161 ! polycystin-1 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens