[Term]
id: PR:Q9Y2I7-3
name: 1-phosphatidylinositol 3-phosphate 5-kinase isoform h3 (human)
def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y2I7-3." [PRO:DNx, UniProtKB:Q9Y2I7]
comment: Category=organism-sequence.
synonym: "hPIKFYVE/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y2I7-3
is_a: PR:Q9Y2I7 ! 1-phosphatidylinositol 3-phosphate 5-kinase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y2I7-2
name: 1-phosphatidylinositol 3-phosphate 5-kinase isoform h2 (human)
def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y2I7-2." [PRO:DNx, UniProtKB:Q9Y2I7]
comment: Category=organism-sequence.
synonym: "hPIKFYVE/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y2I7-2
is_a: PR:Q9Y2I7 ! 1-phosphatidylinositol 3-phosphate 5-kinase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y2I7-1
name: 1-phosphatidylinositol 3-phosphate 5-kinase isoform h1 (human)
def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y2I7-1." [PRO:DNx, UniProtKB:Q9Y2I7]
comment: Category=organism-sequence.
synonym: "hPIKFYVE/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y2I7-1
is_a: PR:Q9Y2I7 ! 1-phosphatidylinositol 3-phosphate 5-kinase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048773
name: 1-phosphatidylinositol 3-phosphate 5-kinase, initiator methionine removed form (human)
def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (human) that has had the initiator methionine removed. UniProtKB:Q9Y2I7, 2-2098." [PRO:DNx, Reactome:R-HSA-1806191, Reactome:R-HSA-1806257, Reactome:R-HSA-1806280]
comment: Category=organism-modification.
synonym: "PRO_0000185452" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPIKFYVE/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y2I7, 2-2098" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1806191 "PR:000048773 located_in GO:0031902"
xref: Reactome:R-HSA-1806257 "PR:000048773 located_in GO:0000139"
xref: Reactome:R-HSA-1806280 "PR:000048773 located_in GO:0031901"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q9Y2I7 ! 1-phosphatidylinositol 3-phosphate 5-kinase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000012747
name: 1-phosphatidylinositol 3-phosphate 5-kinase
def: "A protein that is a translation product of the human PIKFYVE gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "p235" BROAD [PRO:DNx]
synonym: "PIP5K3" RELATED Gene-based []
synonym: "PIKFYVE" EXACT PRO-short-label [PRO:DNx]
synonym: "PIKfyve" EXACT []
synonym: "KIAA0981" RELATED Gene-based []
synonym: "PIPkin-III" EXACT []
synonym: "type III PIP kinase" EXACT []
synonym: "serine-protein kinase PIKFYVE" EXACT []
synonym: "phosphatidylinositol 3-phosphate 5-kinase" EXACT []
synonym: "phosphatidylinositol-3-phosphate 5-kinase" EXACT []
synonym: "FYVE finger-containing phosphoinositide kinase" EXACT []
synonym: "phosphatidylinositol 3-phosphate 5-kinase type III" EXACT []
synonym: "phosphatidylinositol-3-phosphate 5-kinase type III" EXACT []
xref: IUPHARobj:2857
is_a: PR:000000001 ! protein

[Term]
id: PR:000046097
name: 1-phosphatidylinositol 3-phosphate 5-kinase phosphorylated 1 (human)
def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (human) that has been phosphorylated at the position equivalent to Ser-318 of the amino acid sequence represented by UniProtKB:Q9Y2I7-1. Example: UniProtKB:Q9Y2I7-1, Ser-318, MOD:00046." [PMID:20513353, iPTMnet:Q9Y2I7]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:20513353). Status=unreviewed.
synonym: "hPIKFYVE/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y2I7-1, Ser-318, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q9Y2I7 ! 1-phosphatidylinositol 3-phosphate 5-kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y2I7-4
name: 1-phosphatidylinositol 3-phosphate 5-kinase isoform h4 (human)
def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y2I7-4." [PRO:DNx, UniProtKB:Q9Y2I7]
comment: Category=organism-sequence.
synonym: "hPIKFYVE/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y2I7-4
is_a: PR:Q9Y2I7 ! 1-phosphatidylinositol 3-phosphate 5-kinase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y2I7
name: 1-phosphatidylinositol 3-phosphate 5-kinase (human)
def: "A 1-phosphatidylinositol 3-phosphate 5-kinase that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9Y2I7]
comment: Category=organism-gene.
synonym: "PIP5K3" RELATED Gene-based [UniProtKB:Q9Y2I7]
synonym: "PIKFYVE" RELATED Gene-based [UniProtKB:Q9Y2I7]
synonym: "KIAA0981" RELATED Gene-based [UniProtKB:Q9Y2I7]
synonym: "hPIKFYVE" EXACT PRO-short-label [PRO:DNx]
synonym: "PIKfyve (human)" EXACT [UniProtKB:Q9Y2I7]
synonym: "PIPkin-III (human)" EXACT [UniProtKB:Q9Y2I7]
synonym: "type III PIP kinase (human)" EXACT [UniProtKB:Q9Y2I7]
synonym: "serine-protein kinase PIKFYVE (human)" EXACT [UniProtKB:Q9Y2I7]
synonym: "phosphatidylinositol 3-phosphate 5-kinase (human)" EXACT [UniProtKB:Q9Y2I7]
synonym: "FYVE finger-containing phosphoinositide kinase (human)" EXACT [UniProtKB:Q9Y2I7]
synonym: "phosphatidylinositol 3-phosphate 5-kinase type III (human)" EXACT [UniProtKB:Q9Y2I7]
xref: UniProtKB:Q9Y2I7
xref: DTO:03100157
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012747 ! 1-phosphatidylinositol 3-phosphate 5-kinase
relationship: has_gene_template HGNC:23785 ! PIKFYVE (human)