[Term]
id: PR:000012580
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase that is a translation product of the human PFKFB3 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PFKFB3" EXACT PRO-short-label [PRO:DNx]
synonym: "iPFK-2" EXACT []
synonym: "PFK/FBPase 3" EXACT []
synonym: "6PF-2-K/Fru-2,6-P2ase 3" EXACT []
synonym: "renal carcinoma antigen NY-REN-56" EXACT []
synonym: "6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme" EXACT []
synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3" EXACT []
xref: IUPHARobj:2937
is_a: PR:000029977 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

[Term]
id: PR:Q16875-2
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 2 (human)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPFKFB3/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q16875-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000040755 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 2

[Term]
id: PR:Q16875-1
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 1 (human)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPFKFB3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q16875-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000040754 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 1

[Term]
id: PR:000045962
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 phosphorylated 1 (human)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (human) that has been phosphorylated at the position equivalent to Ser-461 of the amino acid sequence represented by UniProtKB:Q16875-1. Example: UniProtKB:Q16875-1, Ser-461, MOD:00046." [PMID:12065600, iPTMnet:Q16875]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12065600). Status=unreviewed.
synonym: "hPFKFB3/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q16875-1, Ser-461, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q16875 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q16875-3
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform h3 (human)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16875-3." [PRO:DNx, UniProtKB:Q16875]
comment: Category=organism-sequence.
synonym: "hPFKFB3/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q16875-3
is_a: PR:Q16875 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q16875-4
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform h4 (human)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16875-4." [PRO:DNx, UniProtKB:Q16875]
comment: Category=organism-sequence.
synonym: "hPFKFB3/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q16875-4
is_a: PR:Q16875 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q16875
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (human)
def: "A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q16875]
comment: Category=organism-gene.
synonym: "PFKFB3" RELATED Gene-based [UniProtKB:Q16875]
synonym: "hPFKFB3" EXACT PRO-short-label [PRO:DNx]
synonym: "iPFK-2 (human)" EXACT [UniProtKB:Q16875]
synonym: "PFK/FBPase 3 (human)" EXACT [UniProtKB:Q16875]
synonym: "6PF-2-K/Fru-2,6-P2ase 3 (human)" EXACT [UniProtKB:Q16875]
synonym: "renal carcinoma antigen NY-REN-56 (human)" EXACT [UniProtKB:Q16875]
synonym: "6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme (human)" EXACT [UniProtKB:Q16875]
xref: DTO:03100632
xref: UniProtKB:Q16875
xref: Reactome:R-HSA-71794 "PR:Q16875 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012580 ! 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
relationship: has_gene_template HGNC:8874 ! PFKFB3 (human)