[Term]
id: PR:000012477
name: cGMP-specific 3',5'-cyclic phosphodiesterase
def: "A GAF-containing cyclic nucleotide-dependent 3',5'-cyclic phosphodiesterase that is a translation product of the human PDE5A gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PDE5" RELATED Gene-based []
synonym: "PDE5A" EXACT PRO-short-label [PRO:DNx]
synonym: "CGB-PDE" EXACT []
synonym: "cGMP-binding cGMP-specific phosphodiesterase" EXACT []
xref: IUPHARobj:1304
is_a: PR:000050164 ! GAF-containing cyclic nucleotide-dependent 3',5'-cyclic phosphodiesterase

[Term]
id: PR:O76074-1
name: cGMP-specific 3',5'-cyclic phosphodiesterase isoform hPDE5A1 (human)
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O76074-1." [PRO:DNx, UniProtKB:O76074]
comment: Category=organism-sequence.
synonym: "hPDE5A/iso:hPDE5A1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O76074-1
is_a: PR:O76074 ! cGMP-specific 3',5'-cyclic phosphodiesterase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O76074
name: cGMP-specific 3',5'-cyclic phosphodiesterase (human)
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase that is encoded in the genome of human." [PRO:DNx, UniProtKB:O76074]
comment: Category=organism-gene.
synonym: "PDE5" RELATED Gene-based [UniProtKB:O76074]
synonym: "PDE5A" RELATED Gene-based [UniProtKB:O76074]
synonym: "hPDE5A" EXACT PRO-short-label [PRO:DNx]
synonym: "CGB-PDE (human)" EXACT [UniProtKB:O76074]
synonym: "cGMP-binding cGMP-specific phosphodiesterase (human)" EXACT [UniProtKB:O76074]
xref: Reactome:R-HSA-418508 "PR:O76074 located_in GO:0005829"
xref: UniProtKB:O76074
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012477 ! cGMP-specific 3',5'-cyclic phosphodiesterase
relationship: has_gene_template HGNC:8784 ! PDE5A (human)

[Term]
id: PR:000045614
name: cGMP-specific 3',5'-cyclic phosphodiesterase phosphorylated 1 (human)
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase (human) that has been phosphorylated at the position equivalent to Ser-102 of the amino acid sequence represented by UniProtKB:O76074-1. Example: UniProtKB:O76074-1, Ser-102, MOD:00046." [PMID:16690614, iPTMnet:O76074]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:16690614). Status=unreviewed.
synonym: "hPDE5A/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O76074-1, Ser-102, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O76074 ! cGMP-specific 3',5'-cyclic phosphodiesterase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O76074-2
name: cGMP-specific 3',5'-cyclic phosphodiesterase isoform PDE5A2 (human)
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase isoform PDE5A2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPDE5A/iso:PDE5A2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O76074-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038430 ! cGMP-specific 3',5'-cyclic phosphodiesterase isoform PDE5A2