[Term]
id: PR:000012477
name: cGMP-specific 3',5'-cyclic phosphodiesterase
def: "A GAF-containing cyclic nucleotide-dependent 3',5'-cyclic phosphodiesterase that is a translation product of the human PDE5A gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PDE5" RELATED Gene-based []
synonym: "PDE5A" EXACT PRO-short-label [PRO:DNx]
synonym: "CGB-PDE" EXACT []
synonym: "cGMP-binding cGMP-specific phosphodiesterase" EXACT []
xref: IUPHARobj:1304
is_a: PR:000050164 ! GAF-containing cyclic nucleotide-dependent 3',5'-cyclic phosphodiesterase

[Term]
id: PR:000038430
name: cGMP-specific 3',5'-cyclic phosphodiesterase isoform PDE5A2
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O76074-2 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "PDE5A isoform 2" EXACT [PRO:DNx]
synonym: "PDE5A/iso:PDE5A2" EXACT PRO-short-label [PRO:DNx]
synonym: "cGMP-specific 3',5'-cyclic phosphodiesterase isoform 2" EXACT [PRO:DNx]
is_a: PR:000012477 ! cGMP-specific 3',5'-cyclic phosphodiesterase

[Term]
id: PR:000045614
name: cGMP-specific 3',5'-cyclic phosphodiesterase phosphorylated 1 (human)
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase (human) that has been phosphorylated at the position equivalent to Ser-102 of the amino acid sequence represented by UniProtKB:O76074-1. Example: UniProtKB:O76074-1, Ser-102, MOD:00046." [PMID:16690614, iPTMnet:O76074]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:16690614). Status=unreviewed.
synonym: "hPDE5A/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O76074-1, Ser-102, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O76074 ! cGMP-specific 3',5'-cyclic phosphodiesterase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O54735-2
name: cGMP-specific 3',5'-cyclic phosphodiesterase isoform rPDE5A1 (rat)
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O54735-2." [PRO:DNx, UniProtKB:O54735]
comment: Category=organism-sequence.
synonym: "rPDE5A/iso:rPDE5A1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O54735-2
is_a: PR:O54735 ! cGMP-specific 3',5'-cyclic phosphodiesterase (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:O54735-1
name: cGMP-specific 3',5'-cyclic phosphodiesterase isoform PDE5A2 (rat)
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase isoform PDE5A2 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rPDE5A/iso:PDE5A2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O54735-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038430 ! cGMP-specific 3',5'-cyclic phosphodiesterase isoform PDE5A2

[Term]
id: PR:Q8CG03
name: cGMP-specific 3',5'-cyclic phosphodiesterase (mouse)
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase that is encoded in the genome of mouse." [OMA:Q8CG03, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pde5" RELATED Gene-based [UniProtKB:Q8CG03]
synonym: "Pde5a" RELATED Gene-based [UniProtKB:Q8CG03]
synonym: "mPDE5A" EXACT PRO-short-label [PRO:DNx]
synonym: "CGB-PDE (mouse)" EXACT [UniProtKB:Q8CG03]
synonym: "cGMP-binding cGMP-specific phosphodiesterase (mouse)" EXACT [UniProtKB:Q8CG03]
xref: UniProtKB:Q8CG03
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000012477 ! cGMP-specific 3',5'-cyclic phosphodiesterase
relationship: has_gene_template MGI:2651499 ! Pde5a (mouse)

[Term]
id: PR:O76074
name: cGMP-specific 3',5'-cyclic phosphodiesterase (human)
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase that is encoded in the genome of human." [PRO:DNx, UniProtKB:O76074]
comment: Category=organism-gene.
synonym: "PDE5" RELATED Gene-based [UniProtKB:O76074]
synonym: "PDE5A" RELATED Gene-based [UniProtKB:O76074]
synonym: "hPDE5A" EXACT PRO-short-label [PRO:DNx]
synonym: "CGB-PDE (human)" EXACT [UniProtKB:O76074]
synonym: "cGMP-binding cGMP-specific phosphodiesterase (human)" EXACT [UniProtKB:O76074]
xref: Reactome:R-HSA-418508 "PR:O76074 located_in GO:0005829"
xref: UniProtKB:O76074
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012477 ! cGMP-specific 3',5'-cyclic phosphodiesterase
relationship: has_gene_template HGNC:8784 ! PDE5A (human)

[Term]
id: PR:O54735
name: cGMP-specific 3',5'-cyclic phosphodiesterase (rat)
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase that is encoded in the genome of rat." [PANTHER:PTHR11347:SF21, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pde5" RELATED Gene-based [UniProtKB:O54735]
synonym: "Pde5a" RELATED Gene-based [UniProtKB:O54735]
synonym: "rPDE5A" EXACT PRO-short-label [PRO:DNx]
synonym: "CGB-PDE (rat)" EXACT [UniProtKB:O54735]
synonym: "cGMP-binding cGMP-specific phosphodiesterase (rat)" EXACT [UniProtKB:O54735]
xref: UniProtKB:O54735
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000012477 ! cGMP-specific 3',5'-cyclic phosphodiesterase
relationship: has_gene_template RGD:620995 ! Pde5a (rat)

[Term]
id: PR:O76074-2
name: cGMP-specific 3',5'-cyclic phosphodiesterase isoform PDE5A2 (human)
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase isoform PDE5A2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPDE5A/iso:PDE5A2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O76074-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038430 ! cGMP-specific 3',5'-cyclic phosphodiesterase isoform PDE5A2

[Term]
id: PR:O76074-1
name: cGMP-specific 3',5'-cyclic phosphodiesterase isoform hPDE5A1 (human)
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O76074-1." [PRO:DNx, UniProtKB:O76074]
comment: Category=organism-sequence.
synonym: "hPDE5A/iso:hPDE5A1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O76074-1
is_a: PR:O76074 ! cGMP-specific 3',5'-cyclic phosphodiesterase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q28156
name: cGMP-specific 3',5'-cyclic phosphodiesterase (cow)
def: "A cGMP-specific 3',5'-cyclic phosphodiesterase that is encoded in the genome of cow." [OMA:Q28156, PRO:DNx]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "PDE5" RELATED Gene-based [UniProtKB:Q28156]
synonym: "PDE5A" RELATED Gene-based [UniProtKB:Q28156]
synonym: "cow-PDE5A" EXACT PRO-short-label [PRO:DNx]
synonym: "CGB-PDE (cow)" EXACT [UniProtKB:Q28156]
synonym: "cGMP-binding cGMP-specific phosphodiesterase (cow)" EXACT [UniProtKB:Q28156]
xref: UniProtKB:Q28156
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000012477 ! cGMP-specific 3',5'-cyclic phosphodiesterase
relationship: has_gene_template NCBIGene:281972 ! PDE5A (cow)