[Term]
id: PR:000012289
name: poly [ADP-ribose] polymerase 1
def: "A protein that is a translation product of the human PARP1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PPOL" RELATED Gene-based []
synonym: "ADPRT" RELATED Gene-based []
synonym: "ARTD1" EXACT []
synonym: "Adprp" RELATED Gene-based []
synonym: "PARP1" EXACT PRO-short-label [PRO:DNx]
synonym: "Adprt1" RELATED Gene-based []
synonym: "PARP-1" EXACT []
synonym: "msPARP" EXACT []
synonym: "ADPRT 1" EXACT []
synonym: "poly[ADP-ribose] synthase 1" EXACT []
synonym: "poly[ADP-ribose] synthetase 1" EXACT []
synonym: "NAD(+) ADP-ribosyltransferase 1" EXACT []
synonym: "DNA ADP-ribosyltransferase PARP1" EXACT []
synonym: "protein poly-ADP-ribosyltransferase PARP1" EXACT []
synonym: "ADP-ribosyltransferase diphtheria toxin-like 1" EXACT []
xref: IUPHARobj:2771
is_a: PR:000000001 ! protein

[Term]
id: PR:000045662
name: poly [ADP-ribose] polymerase 1 phosphorylated 1 (human)
def: "A poly [ADP-ribose] polymerase 1 (human) that has been phosphorylated at Ser-177. UniProtKB:P09874, Ser-177, MOD:00046." [PMID:23382195, iPTMnet:P09874]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:23382195). Status=unreviewed.
synonym: "hPARP1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P09874, Ser-177, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P09874 ! poly [ADP-ribose] polymerase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P09874
name: poly [ADP-ribose] polymerase 1 (human)
def: "A poly [ADP-ribose] polymerase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P09874]
comment: Category=organism-gene.
synonym: "PPOL" RELATED Gene-based [UniProtKB:P09874]
synonym: "ADPRT" RELATED Gene-based [UniProtKB:P09874]
synonym: "PARP1" RELATED Gene-based [UniProtKB:P09874]
synonym: "hPARP1" EXACT PRO-short-label [PRO:DNx]
synonym: "ARTD1 (human)" EXACT [UniProtKB:P09874]
synonym: "PARP-1 (human)" EXACT [UniProtKB:P09874]
synonym: "ADPRT 1 (human)" EXACT [UniProtKB:P09874]
synonym: "poly[ADP-ribose] synthase 1 (human)" EXACT [UniProtKB:P09874]
synonym: "NAD(+) ADP-ribosyltransferase 1 (human)" EXACT [UniProtKB:P09874]
synonym: "DNA ADP-ribosyltransferase PARP1 (human)" EXACT [UniProtKB:P09874]
synonym: "protein poly-ADP-ribosyltransferase PARP1 (human)" EXACT [UniProtKB:P09874]
synonym: "ADP-ribosyltransferase diphtheria toxin-like 1 (human)" EXACT [UniProtKB:P09874]
xref: UniProtKB:P09874
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012289 ! poly [ADP-ribose] polymerase 1
relationship: has_gene_template HGNC:270 ! PARP1 (human)

[Term]
id: PR:000048696
name: poly [ADP-ribose] polymerase 1, initiator methionine removed ADP-ribosylglutamate form (human)
def: "A poly [ADP-ribose] polymerase 1 (human) that has had the initiator methionine removed and that includes at least one ADP-ribosylated glutamic acid. UniProtKB:P09874, 2-1014, MOD:00300." [PRO:DNx, Reactome:R-HSA-5651713]
comment: Category=organism-modification.
synonym: "PRO_0000211320, MOD:00300" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPARP1/InitMet-/ADPribGlu+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P09874, 2-1014, MOD:00300" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5651713 "PR:000048696 located_in GO:0005654"
intersection_of: has_part MOD:00300 ! L-glutamyl-5-poly(ADP-ribose)
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P09874 ! poly [ADP-ribose] polymerase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048695
name: poly [ADP-ribose] polymerase 1, initiator methionine removed form (human)
def: "A poly [ADP-ribose] polymerase 1 (human) that has had the initiator methionine removed. UniProtKB:P09874, 2-1014." [PRO:DNx, Reactome:R-HSA-201568]
comment: Category=organism-modification.
synonym: "PRO_0000211320" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPARP1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P09874, 2-1014" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201568 "PR:000048695 located_in GO:0005654"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P09874 ! poly [ADP-ribose] polymerase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens