[Term]
id: PR:000045626
name: phenylalanine-4-hydroxylase phosphorylated 1 (human)
def: "A phenylalanine-4-hydroxylase (human) that has been phosphorylated at Ser-16. UniProtKB:P00439, Ser-16, MOD:00046." [PMID:12185072, PMID:20937381, iPTMnet:P00439]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12185072, PMID:20937381). Status=unreviewed.
synonym: "hPAH/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00439, Ser-16, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P00439 ! phenylalanine-4-hydroxylase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P00439
name: phenylalanine-4-hydroxylase (human)
def: "A phenylalanine-4-hydroxylase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P00439]
comment: Category=organism-gene.
synonym: "PAH" RELATED Gene-based [UniProtKB:P00439]
synonym: "hPAH" EXACT PRO-short-label [PRO:DNx]
synonym: "Phe-4-monooxygenase (human)" EXACT [UniProtKB:P00439]
xref: UniProtKB:P00439
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012234 ! phenylalanine-4-hydroxylase
relationship: has_gene_template HGNC:8582 ! PAH (human)

[Term]
id: PR:P90925-2
name: phenylalanine-4-hydroxylase isoform b (worm)
def: "A phenylalanine-4-hydroxylase (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P90925-2." [PRO:DNx, UniProtKB:P90925]
comment: Category=organism-sequence.
synonym: "PAH/iso:b (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P90925-2
is_a: PR:P90925 ! phenylalanine-4-hydroxylase (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:P90925-1
name: phenylalanine-4-hydroxylase isoform a (worm)
def: "A phenylalanine-4-hydroxylase (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P90925-1." [PRO:DNx, UniProtKB:P90925]
comment: Category=organism-sequence.
synonym: "PAH/iso:a (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P90925-1
is_a: PR:P90925 ! phenylalanine-4-hydroxylase (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:Q54XS1
name: phenylalanine-4-hydroxylase (Dictyostelium discoideum)
def: "A phenylalanine-4-hydroxylase that is encoded in the genome of Dictyostelium discoideum." [PRO:DNx]
comment: Category=organism-gene.
synonym: "pah" RELATED Gene-based [UniProtKB:Q54XS1]
synonym: "Dicty-PAH" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0278781" RELATED Gene-based [UniProtKB:Q54XS1]
synonym: "PAH (Dictyostelium discoideum)" EXACT [UniProtKB:Q54XS1]
synonym: "TRH (Dictyostelium discoideum)" EXACT [UniProtKB:Q54XS1]
synonym: "Phe-4-monooxygenase (Dictyostelium discoideum)" EXACT [UniProtKB:Q54XS1]
synonym: "tryptophan 5-hydroxylase (Dictyostelium discoideum)" EXACT [UniProtKB:Q54XS1]
synonym: "tryptophan 5-monooxygenase (Dictyostelium discoideum)" EXACT [UniProtKB:Q54XS1]
xref: UniProtKB:Q54XS1
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000012234 ! phenylalanine-4-hydroxylase
relationship: has_gene_template dictyBase:DDB_G0278781 ! pah (Dictyostelium discoideum)

[Term]
id: PR:000012234
name: phenylalanine-4-hydroxylase
def: "A protein that is a translation product of the human PAH gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PAH" EXACT PRO-short-label [PRO:DNx]
synonym: "Phe-4-monooxygenase" EXACT []
xref: IUPHARobj:1240
is_a: PR:000000001 ! protein

[Term]
id: PR:P16331
name: phenylalanine-4-hydroxylase (mouse)
def: "A phenylalanine-4-hydroxylase that is encoded in the genome of mouse." [OMA:P16331, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pah" RELATED Gene-based [UniProtKB:P16331]
synonym: "mPAH" EXACT PRO-short-label [PRO:DNx]
synonym: "PAH (mouse)" EXACT [UniProtKB:P16331]
synonym: "Phe-4-monooxygenase (mouse)" EXACT [UniProtKB:P16331]
xref: UniProtKB:P16331
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000012234 ! phenylalanine-4-hydroxylase
relationship: has_gene_template MGI:97473 ! Pah (mouse)

[Term]
id: PR:P04176
name: phenylalanine-4-hydroxylase (rat)
def: "A phenylalanine-4-hydroxylase that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-gene.
synonym: "Pah" RELATED Gene-based [UniProtKB:P04176]
synonym: "rPAH" EXACT PRO-short-label [PRO:DNx]
synonym: "PAH (rat)" EXACT [UniProtKB:P04176]
synonym: "Phe-4-monooxygenase (rat)" EXACT [UniProtKB:P04176]
xref: UniProtKB:P04176
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000012234 ! phenylalanine-4-hydroxylase
relationship: has_gene_template RGD:3248 ! Pah (rat)

[Term]
id: PR:P90925
name: phenylalanine-4-hydroxylase (worm)
def: "A phenylalanine-4-hydroxylase that is encoded in the genome of worm." [OMA:P90925, PRO:DNx]
comment: Category=organism-gene.
synonym: "bas-2" RELATED Gene-based [UniProtKB:P90925]
synonym: "pah-1" RELATED Gene-based [UniProtKB:P90925]
synonym: "K08F8.4" RELATED Gene-based [UniProtKB:P90925]
synonym: "PAH (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "Phe-4-monooxygenase (worm)" EXACT [UniProtKB:P90925]
synonym: "tryptophan 5-monooxygenase (worm)" EXACT [UniProtKB:P90925]
synonym: "biogenic amine synthesis protein 2 (worm)" EXACT [UniProtKB:P90925]
xref: UniProtKB:P90925
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000012234 ! phenylalanine-4-hydroxylase
relationship: has_gene_template WormBase:WBGene00000240 ! pah-1 (worm)

[Term]
id: PR:000020863
name: phenylalanine-4-hydroxylase, initiator methionine removed form
def: "A phenylalanine-4-hydroxylase that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "PAH/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000012234 ! phenylalanine-4-hydroxylase
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P17276
name: protein henna (fruit fly)
def: "A phenylalanine-4-hydroxylase that is encoded in the genome of fruit fly." [OMA:P17276, PRO:DNx]
comment: Category=organism-gene.
synonym: "Hn" RELATED Gene-based [UniProtKB:P17276]
synonym: "Tph" RELATED Gene-based [UniProtKB:P17276]
synonym: "pah" RELATED Gene-based [UniProtKB:P17276]
synonym: "CG7399" RELATED Gene-based [UniProtKB:P17276]
synonym: "fly-PAH" EXACT PRO-short-label [PRO:DNx]
synonym: "PAH (fruit fly)" EXACT [UniProtKB:P17276]
synonym: "TRH (fruit fly)" EXACT [UniProtKB:P17276]
synonym: "Phe-4-monooxygenase (fruit fly)" EXACT [UniProtKB:P17276]
synonym: "tryptophan 5-hydroxylase (fruit fly)" EXACT [UniProtKB:P17276]
synonym: "tryptophan 5-monooxygenase (fruit fly)" EXACT [UniProtKB:P17276]
synonym: "phenylalanine-4-hydroxylase (fruit fly)" EXACT [UniProtKB:P17276]
xref: UniProtKB:P17276
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000012234 ! phenylalanine-4-hydroxylase
relationship: has_gene_template FlyBase:FBgn0001208 ! Hn (fruit fly)

[Term]
id: PR:000048685
name: phenylalanine-4-hydroxylase, initiator methionine removed form (human)
def: "A phenylalanine-4-hydroxylase (human) that has had the initiator methionine removed. UniProtKB:P00439, 2-452." [PRO:DNx, Reactome:R-HSA-71066]
comment: Category=organism-modification.
synonym: "hPAH/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000205548" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P00439, 2-452" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-71066 "PR:000048685 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P00439 ! phenylalanine-4-hydroxylase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens