[Term]
id: PR:000011652
name: optineurin
def: "A protein that is a translation product of the human OPTN gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "NRP" RELATED Gene-based []
synonym: "FIP2" RELATED Gene-based []
synonym: "HIP7" RELATED Gene-based []
synonym: "HYPL" RELATED Gene-based []
synonym: "OPTN" EXACT PRO-short-label [PRO:DNx]
synonym: "FIP-2" EXACT []
synonym: "GLC1E" RELATED Gene-based []
synonym: "HIP-7" EXACT []
synonym: "TFIIIA-IntP" EXACT []
synonym: "NEMO-related protein" EXACT []
synonym: "huntingtin yeast partner L" EXACT []
synonym: "E3-14.7K-interacting protein" EXACT []
synonym: "huntingtin-interacting protein 7" EXACT []
synonym: "huntingtin-interacting protein L" EXACT []
synonym: "optic neuropathy-inducing protein" EXACT []
synonym: "transcription factor IIIA-interacting protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q96CV9
name: optineurin (human)
def: "An optineurin that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q96CV9]
comment: Category=organism-gene.
synonym: "NRP" RELATED Gene-based [UniProtKB:Q96CV9]
synonym: "FIP2" RELATED Gene-based [UniProtKB:Q96CV9]
synonym: "HIP7" RELATED Gene-based [UniProtKB:Q96CV9]
synonym: "HYPL" RELATED Gene-based [UniProtKB:Q96CV9]
synonym: "OPTN" RELATED Gene-based [UniProtKB:Q96CV9]
synonym: "GLC1E" RELATED Gene-based [UniProtKB:Q96CV9]
synonym: "hOPTN" EXACT PRO-short-label [PRO:DNx]
synonym: "FIP-2 (human)" EXACT [UniProtKB:Q96CV9]
synonym: "HIP-7 (human)" EXACT [UniProtKB:Q96CV9]
synonym: "TFIIIA-IntP (human)" EXACT [UniProtKB:Q96CV9]
synonym: "NEMO-related protein (human)" EXACT [UniProtKB:Q96CV9]
synonym: "huntingtin yeast partner L (human)" EXACT [UniProtKB:Q96CV9]
synonym: "E3-14.7K-interacting protein (human)" EXACT [UniProtKB:Q96CV9]
synonym: "huntingtin-interacting protein 7 (human)" EXACT [UniProtKB:Q96CV9]
synonym: "huntingtin-interacting protein L (human)" EXACT [UniProtKB:Q96CV9]
synonym: "optic neuropathy-inducing protein (human)" EXACT [UniProtKB:Q96CV9]
synonym: "transcription factor IIIA-interacting protein (human)" EXACT [UniProtKB:Q96CV9]
xref: UniProtKB:Q96CV9
xref: Reactome:R-HSA-2161111 "PR:Q96CV9 located_in GO:0000139"
xref: Reactome:R-HSA-8854141 "PR:Q96CV9 located_in GO:0055038"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000011652 ! optineurin
relationship: has_gene_template HGNC:17142 ! OPTN (human)

[Term]
id: PR:000046022
name: optineurin phosphorylated 1 (human)
def: "An optineurin (human) that has been phosphorylated at the position equivalent to Ser-177 of the amino acid sequence represented by UniProtKB:Q96CV9-1. Example: UniProtKB:Q96CV9-1, Ser-177, MOD:00046." [PMID:22365832, iPTMnet:Q96CV9]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:22365832). Status=unreviewed.
synonym: "hOPTN/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q96CV9-1, Ser-177, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2562525 "PR:000046022 located_in GO:0005829"
xref: Reactome:R-HSA-2562595 "PR:000046022 located_in GO:0005654"
is_a: PR:Q96CV9 ! optineurin (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96CV9-1
name: optineurin isoform h1 (human)
def: "An optineurin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96CV9-1." [PRO:DNx, UniProtKB:Q96CV9]
comment: Category=organism-sequence.
synonym: "hOPTN/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96CV9-1
is_a: PR:Q96CV9 ! optineurin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96CV9-2
name: optineurin isoform h2 (human)
def: "An optineurin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96CV9-2." [PRO:DNx, UniProtKB:Q96CV9]
comment: Category=organism-sequence.
synonym: "hOPTN/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96CV9-2
is_a: PR:Q96CV9 ! optineurin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96CV9-3
name: optineurin isoform h3 (human)
def: "An optineurin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96CV9-3." [PRO:DNx, UniProtKB:Q96CV9]
comment: Category=organism-sequence.
synonym: "hOPTN/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96CV9-3
is_a: PR:Q96CV9 ! optineurin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens