[Term]
id: PR:Q90Z16
name: optineurin (chicken)
def: "An optineurin that is encoded in the genome of chicken." [OMA:Q90Z16, PRO:DNx]
comment: Category=organism-gene.
synonym: "OPTN" RELATED Gene-based [UniProtKB:Q90Z16]
synonym: "chick-OPTN" EXACT PRO-short-label [PRO:DNx]
synonym: "FIP-2 (chicken)" EXACT [UniProtKB:Q90Z16]
synonym: "Ag9-C5 (chicken)" EXACT [UniProtKB:Q90Z16]
xref: UniProtKB:Q90Z16
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000011652 ! optineurin
relationship: has_gene_template NCBIGene:374079 ! OPTN (chicken)

[Term]
id: PR:Q96CV9-2
name: optineurin isoform h2 (human)
def: "An optineurin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96CV9-2." [PRO:DNx, UniProtKB:Q96CV9]
comment: Category=organism-sequence.
synonym: "hOPTN/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96CV9-2
is_a: PR:Q96CV9 ! optineurin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96CV9
name: optineurin (human)
def: "An optineurin that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q96CV9]
comment: Category=organism-gene.
synonym: "NRP" RELATED Gene-based [UniProtKB:Q96CV9]
synonym: "FIP2" RELATED Gene-based [UniProtKB:Q96CV9]
synonym: "HIP7" RELATED Gene-based [UniProtKB:Q96CV9]
synonym: "HYPL" RELATED Gene-based [UniProtKB:Q96CV9]
synonym: "OPTN" RELATED Gene-based [UniProtKB:Q96CV9]
synonym: "GLC1E" RELATED Gene-based [UniProtKB:Q96CV9]
synonym: "hOPTN" EXACT PRO-short-label [PRO:DNx]
synonym: "FIP-2 (human)" EXACT [UniProtKB:Q96CV9]
synonym: "HIP-7 (human)" EXACT [UniProtKB:Q96CV9]
synonym: "TFIIIA-IntP (human)" EXACT [UniProtKB:Q96CV9]
synonym: "NEMO-related protein (human)" EXACT [UniProtKB:Q96CV9]
synonym: "huntingtin yeast partner L (human)" EXACT [UniProtKB:Q96CV9]
synonym: "E3-14.7K-interacting protein (human)" EXACT [UniProtKB:Q96CV9]
synonym: "huntingtin-interacting protein 7 (human)" EXACT [UniProtKB:Q96CV9]
synonym: "huntingtin-interacting protein L (human)" EXACT [UniProtKB:Q96CV9]
synonym: "optic neuropathy-inducing protein (human)" EXACT [UniProtKB:Q96CV9]
synonym: "transcription factor IIIA-interacting protein (human)" EXACT [UniProtKB:Q96CV9]
xref: UniProtKB:Q96CV9
xref: Reactome:R-HSA-2161111 "PR:Q96CV9 located_in GO:0000139"
xref: Reactome:R-HSA-8854141 "PR:Q96CV9 located_in GO:0055038"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000011652 ! optineurin
relationship: has_gene_template HGNC:17142 ! OPTN (human)

[Term]
id: PR:Q8R5M4
name: optineurin (rat)
def: "An optineurin that is encoded in the genome of rat." [OMA:Q8R5M4, PRO:DNx]
comment: Category=organism-gene.
synonym: "Optn" RELATED Gene-based [UniProtKB:Q8R5M4]
synonym: "rOPTN" EXACT PRO-short-label [PRO:DNx]
synonym: "FIP-2-like protein (rat)" EXACT [UniProtKB:Q8R5M4]
xref: UniProtKB:Q8R5M4
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000011652 ! optineurin
relationship: has_gene_template RGD:628886 ! Optn (rat)

[Term]
id: PR:000011652
name: optineurin
def: "A protein that is a translation product of the human OPTN gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "NRP" RELATED Gene-based []
synonym: "FIP2" RELATED Gene-based []
synonym: "HIP7" RELATED Gene-based []
synonym: "HYPL" RELATED Gene-based []
synonym: "OPTN" EXACT PRO-short-label [PRO:DNx]
synonym: "FIP-2" EXACT []
synonym: "GLC1E" RELATED Gene-based []
synonym: "HIP-7" EXACT []
synonym: "TFIIIA-IntP" EXACT []
synonym: "NEMO-related protein" EXACT []
synonym: "huntingtin yeast partner L" EXACT []
synonym: "E3-14.7K-interacting protein" EXACT []
synonym: "huntingtin-interacting protein 7" EXACT []
synonym: "huntingtin-interacting protein L" EXACT []
synonym: "optic neuropathy-inducing protein" EXACT []
synonym: "transcription factor IIIA-interacting protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q5RI56-2
name: optineurin isoform 2 (zebrafish)
def: "An optineurin (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5RI56-2." [PRO:DNx, UniProtKB:Q5RI56]
comment: Category=organism-sequence.
synonym: "z-OPTN/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q5RI56-2
is_a: PR:Q5RI56 ! optineurin (zebrafish)
relationship: only_in_taxon NCBITaxon:7955 ! Danio rerio

[Term]
id: PR:Q5RI56-1
name: optineurin isoform 1 (zebrafish)
def: "An optineurin (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5RI56-1." [PRO:DNx, UniProtKB:Q5RI56]
comment: Category=organism-sequence.
synonym: "z-OPTN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q5RI56-1
is_a: PR:Q5RI56 ! optineurin (zebrafish)
relationship: only_in_taxon NCBITaxon:7955 ! Danio rerio

[Term]
id: PR:Q8K3K8
name: optineurin (mouse)
def: "An optineurin that is encoded in the genome of mouse." [OMA:Q8K3K8, PRO:DNx]
comment: Category=organism-gene.
synonym: "Optn" RELATED Gene-based [UniProtKB:Q8K3K8]
synonym: "mOPTN" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8K3K8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000011652 ! optineurin
relationship: has_gene_template MGI:1918898 ! Optn (mouse)

[Term]
id: PR:000046022
name: optineurin phosphorylated 1 (human)
def: "An optineurin (human) that has been phosphorylated at the position equivalent to Ser-177 of the amino acid sequence represented by UniProtKB:Q96CV9-1. Example: UniProtKB:Q96CV9-1, Ser-177, MOD:00046." [PMID:22365832, iPTMnet:Q96CV9]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:22365832). Status=unreviewed.
synonym: "hOPTN/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q96CV9-1, Ser-177, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2562525 "PR:000046022 located_in GO:0005829"
xref: Reactome:R-HSA-2562595 "PR:000046022 located_in GO:0005654"
is_a: PR:Q96CV9 ! optineurin (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8R5M4-2
name: optineurin isoform r2 (rat)
def: "An optineurin (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R5M4-2." [PRO:DNx, UniProtKB:Q8R5M4]
comment: Category=organism-sequence.
synonym: "rOPTN/iso:r2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8R5M4-2
is_a: PR:Q8R5M4 ! optineurin (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q8R5M4-1
name: optineurin isoform r1 (rat)
def: "An optineurin (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R5M4-1." [PRO:DNx, UniProtKB:Q8R5M4]
comment: Category=organism-sequence.
synonym: "rOPTN/iso:r1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8R5M4-1
is_a: PR:Q8R5M4 ! optineurin (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q96CV9-3
name: optineurin isoform h3 (human)
def: "An optineurin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96CV9-3." [PRO:DNx, UniProtKB:Q96CV9]
comment: Category=organism-sequence.
synonym: "hOPTN/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96CV9-3
is_a: PR:Q96CV9 ! optineurin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q5RI56
name: optineurin (zebrafish)
def: "An optineurin that is encoded in the genome of zebrafish." [OMA:Q5RI56, PRO:DNx]
comment: Category=organism-gene.
synonym: "optn" RELATED Gene-based [UniProtKB:Q5RI56]
synonym: "z-OPTN" EXACT PRO-short-label [PRO:DNx]
synonym: "zgc:66386" RELATED Gene-based [UniProtKB:Q5RI56]
synonym: "zgc:77868" RELATED Gene-based [UniProtKB:Q5RI56]
synonym: "si:ch211-240l19.3" RELATED Gene-based [UniProtKB:Q5RI56]
xref: UniProtKB:Q5RI56
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000011652 ! optineurin
relationship: has_gene_template ZFIN:ZDB-GENE-030131-8103 ! optn (zebrafish)

[Term]
id: PR:Q96CV9-1
name: optineurin isoform h1 (human)
def: "An optineurin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96CV9-1." [PRO:DNx, UniProtKB:Q96CV9]
comment: Category=organism-sequence.
synonym: "hOPTN/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96CV9-1
is_a: PR:Q96CV9 ! optineurin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens