[Term]
id: PR:Q96RI1-5
name: bile acid receptor isoform h5 (human)
def: "A bile acid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96RI1-5." [PRO:DNx, UniProtKB:Q96RI1]
comment: Category=organism-sequence.
synonym: "hNR1H4/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96RI1-5
is_a: PR:Q96RI1 ! bile acid receptor (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q60641-2
name: bile acid receptor isoform m2 (mouse)
def: "A bile acid receptor (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60641-2." [PRO:DNx, UniProtKB:Q60641]
comment: Category=organism-sequence.
synonym: "mNR1H4/iso:m2" EXACT PRO-short-label [PRO:DNx]
synonym: "bile acid receptor isoform FXRbeta2 (mouse)" EXACT [UniProtKB:Q60641]
synonym: "bile acid receptor isoform FXFRalpha4 (mouse)" EXACT [UniProtKB:Q60641]
synonym: "bile acid receptor isoform FXRalpha2(-) (mouse)" EXACT [UniProtKB:Q60641]
xref: UniProtKB:Q60641-2
is_a: PR:Q60641 ! bile acid receptor (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q60641-3
name: bile acid receptor isoform m3 (mouse)
def: "A bile acid receptor (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60641-3." [PRO:DNx, UniProtKB:Q60641]
comment: Category=organism-sequence.
synonym: "mNR1H4/iso:m3" EXACT PRO-short-label [PRO:DNx]
synonym: "bile acid receptor isoform FXRalpha1 (mouse)" EXACT [UniProtKB:Q60641]
synonym: "bile acid receptor isoform FXRalpha1(+) (mouse)" EXACT [UniProtKB:Q60641]
xref: UniProtKB:Q60641-3
is_a: PR:Q60641 ! bile acid receptor (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q60641-1
name: bile acid receptor isoform 1 (mouse)
def: "A bile acid receptor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mNR1H4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q60641-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000028574 ! bile acid receptor isoform 1

[Term]
id: PR:Q60641-4
name: bile acid receptor isoform m4 (mouse)
def: "A bile acid receptor (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60641-4." [PRO:DNx, UniProtKB:Q60641]
comment: Category=organism-sequence.
synonym: "mNR1H4/iso:m4" EXACT PRO-short-label [PRO:DNx]
synonym: "bile acid receptor isoform FXRalpha2 (mouse)" EXACT [UniProtKB:Q60641]
synonym: "bile acid receptor isoform FXRalpha1(-) (mouse)" EXACT [UniProtKB:Q60641]
xref: UniProtKB:Q60641-4
is_a: PR:Q60641 ! bile acid receptor (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q96RI1-4
name: bile acid receptor isoform h2 (human)
def: "A bile acid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96RI1-4." [PRO:DNx, UniProtKB:Q96RI1]
comment: Category=organism-sequence.
synonym: "hNR1H4/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "bile acid receptor isoform FXRbeta2 (human)" EXACT [UniProtKB:Q96RI1]
synonym: "bile acid receptor isoform FXRalpha4 (human)" EXACT [UniProtKB:Q96RI1]
synonym: "bile acid receptor isoform FXRalpha2(-) (human)" EXACT [UniProtKB:Q96RI1]
xref: UniProtKB:Q96RI1-4
xref: Reactome:R-HSA-3196157 "PR:Q96RI1-4 located_in GO:0005654"
is_a: PR:Q96RI1 ! bile acid receptor (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96RI1
name: bile acid receptor (human)
def: "A bile acid receptor that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q96RI1]
comment: Category=organism-gene.
synonym: "BAR" RELATED Gene-based [UniProtKB:Q96RI1]
synonym: "FXR" RELATED Gene-based [UniProtKB:Q96RI1]
synonym: "HRR1" RELATED Gene-based [UniProtKB:Q96RI1]
synonym: "NR1H4" RELATED Gene-based [UniProtKB:Q96RI1]
synonym: "RIP14" RELATED Gene-based [UniProtKB:Q96RI1]
synonym: "hNR1H4" EXACT PRO-short-label [PRO:DNx]
synonym: "farnesol receptor HRR-1 (human)" EXACT [UniProtKB:Q96RI1]
synonym: "RXR-interacting protein 14 (human)" EXACT [UniProtKB:Q96RI1]
synonym: "farnesoid X-activated receptor (human)" EXACT [UniProtKB:Q96RI1]
synonym: "retinoid X receptor-interacting protein 14 (human)" EXACT [UniProtKB:Q96RI1]
synonym: "nuclear receptor subfamily 1 group H member 4 (human)" EXACT [UniProtKB:Q96RI1]
xref: UniProtKB:Q96RI1
xref: Reactome:R-HSA-5340228 "PR:Q96RI1 located_in GO:0005654"
xref: DTO:00117493
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000011396 ! bile acid receptor
relationship: has_gene_template HGNC:7967 ! NR1H4 (human)

[Term]
id: PR:Q96RI1-3
name: bile acid receptor isoform h1 (human)
def: "A bile acid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96RI1-3." [PRO:DNx, UniProtKB:Q96RI1]
comment: Category=organism-sequence.
synonym: "hNR1H4/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "bile acid receptor isoform FXRbeta1 (human)" EXACT [UniProtKB:Q96RI1]
synonym: "bile acid receptor isoform FXRalpha1 (human)" BROAD [UniProtKB:Q96RI1]
synonym: "bile acid receptor isoform FXRalpha2(+) (human)" EXACT [UniProtKB:Q96RI1]
xref: UniProtKB:Q96RI1-3
xref: Reactome:R-HSA-3196171 "PR:Q96RI1-3 located_in GO:0005654"
is_a: PR:Q96RI1 ! bile acid receptor (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96RI1-1
name: bile acid receptor isoform 1 (human)
def: "A bile acid receptor isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hNR1H4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96RI1-1
xref: Reactome:R-HSA-3008624 "PR:Q96RI1-1 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028574 ! bile acid receptor isoform 1

[Term]
id: PR:Q96RI1-2
name: bile acid receptor isoform h4 (human)
def: "A bile acid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96RI1-2." [PRO:DNx, UniProtKB:Q96RI1]
comment: Category=organism-sequence.
synonym: "hNR1H4/iso:h4" EXACT PRO-short-label [PRO:DNx]
synonym: "bile acid receptor isoform FXRalpha2 (human)" EXACT [UniProtKB:Q96RI1]
synonym: "bile acid receptor isoform FXRalpha1(-) (human)" EXACT [UniProtKB:Q96RI1]
xref: UniProtKB:Q96RI1-2
xref: Reactome:R-HSA-3196161 "PR:Q96RI1-2 located_in GO:0005654"
is_a: PR:Q96RI1 ! bile acid receptor (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q62735
name: bile acid receptor (rat)
def: "A bile acid receptor that is encoded in the genome of rat." [OMA:Q62735, PANTHER:PTHR24082:SF160, PRO:DNx]
comment: Category=organism-gene.
synonym: "Bar" RELATED Gene-based [UniProtKB:Q62735]
synonym: "Fxr" RELATED Gene-based [UniProtKB:Q62735]
synonym: "Nr1h4" RELATED Gene-based [UniProtKB:Q62735]
synonym: "Rip14" RELATED Gene-based [UniProtKB:Q62735]
synonym: "rNR1H4" EXACT PRO-short-label [PRO:DNx]
synonym: "farnesol receptor HRR-1 (rat)" EXACT [UniProtKB:Q62735]
synonym: "RXR-interacting protein 14 (rat)" EXACT [UniProtKB:Q62735]
synonym: "farnesoid X-activated receptor (rat)" EXACT [UniProtKB:Q62735]
synonym: "retinoid X receptor-interacting protein 14 (rat)" EXACT [UniProtKB:Q62735]
synonym: "nuclear receptor subfamily 1 group H member 4 (rat)" EXACT [UniProtKB:Q62735]
xref: UniProtKB:Q62735
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000011396 ! bile acid receptor
relationship: has_gene_template RGD:628831 ! Nr1h4 (rat)

[Term]
id: PR:000028576
name: bile acid receptor isoform 1 acetylated 1
def: "A bile acid receptor isoform 1 that acetylated on a Lys residue within the DNA binding domain (Zinc finger, C4 type (two domain), Pfam:PF00105), and a highly conserved Lys residue within the hinge region. Example: UniProtKB:Q96RI1-1, Lys-157/Lys-217, MOD:00064." [KAT:Q96RI1, PMID:19883617, PRO:PD]
comment: Category=modification.
synonym: "FXR acetylated" RELATED []
synonym: "NR1H4/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000028574 ! bile acid receptor isoform 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000028577
name: bile acid receptor isoform 1 acetylated 1 (human)
def: "A bile acid receptor isoform 1 acetylated 1 in human. UniProtKB:Q96RI1-1, Lys-157/Lys-217, MOD:00064." [KAT:Q96RI1, PMID:19883617, PRO:PD]
comment: Category=organism-modification. Acetylase=("EP300"; PR:000007102).
synonym: "hNR1H4/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "FXR acetylated (human)" RELATED []
synonym: "UniProtKB:Q96RI1-1, Lys-157/Lys-217, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028576 ! bile acid receptor isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000028574
name: bile acid receptor isoform 1
def: "A bile acid receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96RI1-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "NR1H4/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "bile acid receptor isoform 3" EXACT [UniProtKB:Q96RI1]
is_a: PR:000011396 ! bile acid receptor

[Term]
id: PR:Q60641
name: bile acid receptor (mouse)
def: "A bile acid receptor that is encoded in the genome of mouse." [OMA:Q60641, PRO:DNx]
comment: Category=organism-gene.
synonym: "Bar" RELATED Gene-based [UniProtKB:Q60641]
synonym: "Fxr" RELATED Gene-based [UniProtKB:Q60641]
synonym: "Nr1h4" RELATED Gene-based [UniProtKB:Q60641]
synonym: "Rip14" RELATED Gene-based [UniProtKB:Q60641]
synonym: "mNR1H4" EXACT PRO-short-label [PRO:DNx]
synonym: "farnesol receptor HRR-1 (mouse)" EXACT [UniProtKB:Q60641]
synonym: "RXR-interacting protein 14 (mouse)" EXACT [UniProtKB:Q60641]
synonym: "farnesoid X-activated receptor (mouse)" EXACT [UniProtKB:Q60641]
synonym: "retinoid X receptor-interacting protein 14 (mouse)" EXACT [UniProtKB:Q60641]
synonym: "nuclear receptor subfamily 1 group H member 4 (mouse)" EXACT [UniProtKB:Q60641]
xref: UniProtKB:Q60641
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000011396 ! bile acid receptor
relationship: has_gene_template MGI:1352464 ! Nr1h4 (mouse)

[Term]
id: PR:000011396
name: bile acid receptor
def: "A protein that is a translation product of the human NR1H4 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "BAR" RELATED Gene-based []
synonym: "FXR" RELATED Gene-based []
synonym: "HRR1" RELATED Gene-based []
synonym: "NR1H4" EXACT PRO-short-label [PRO:DNx]
synonym: "RIP14" RELATED Gene-based []
synonym: "farnesol receptor HRR-1" EXACT []
synonym: "RXR-interacting protein 14" EXACT []
synonym: "farnesoid X-activated receptor" EXACT []
synonym: "retinoid X receptor-interacting protein 14" EXACT []
synonym: "nuclear receptor subfamily 1 group H member 4" EXACT []
xref: IUPHARobj:603
is_a: PR:000000001 ! protein