[Term]
id: PR:P18908
name: natriuretic peptides A (chicken)
def: "An atrial natriuretic factor that is encoded in the genome of chicken." [PRO:DNx]
comment: Category=organism-gene.
synonym: "NPPA" RELATED Gene-based [UniProtKB:P18908]
synonym: "chick-NPPA" EXACT PRO-short-label [PRO:DNx]
synonym: "prepronatriodilatin (chicken)" EXACT [UniProtKB:P18908]
xref: UniProtKB:P18908
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000011374 ! atrial natriuretic factor
relationship: has_gene_template NCBIGene:395765 ! NPPA (chicken)

[Term]
id: PR:P05125-1
name: natriuretic peptides A isoform 1 (mouse)
def: "An atrial natriuretic factor isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mNPPA/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05125-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038666 ! atrial natriuretic factor isoform 1

[Term]
id: PR:P01161
name: natriuretic peptides A (rat)
def: "An atrial natriuretic factor that is encoded in the genome of rat." [OMA:P01161, PANTHER:PTHR14066:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nppa" RELATED Gene-based [UniProtKB:P01161]
synonym: "rNPPA" EXACT PRO-short-label [PRO:DNx]
synonym: "CDD (rat)" EXACT [UniProtKB:P01161]
synonym: "proANF (rat)" EXACT [UniProtKB:P01161]
synonym: "proANP (rat)" EXACT [UniProtKB:P01161]
synonym: "preproANF (rat)" EXACT [UniProtKB:P01161]
synonym: "preproANP (rat)" EXACT [UniProtKB:P01161]
synonym: "atriopeptigen (rat)" EXACT [UniProtKB:P01161]
synonym: "cardiodilatin (rat)" EXACT [UniProtKB:P01161]
synonym: "preproCDD-ANF (rat)" EXACT [UniProtKB:P01161]
synonym: "atrial natriuretic factor prohormone (rat)" EXACT [UniProtKB:P01161]
synonym: "atrial natriuretic peptide prohormone (rat)" EXACT [UniProtKB:P01161]
xref: UniProtKB:P01161
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000011374 ! atrial natriuretic factor
relationship: has_gene_template RGD:3193 ! Nppa (rat)

[Term]
id: PR:000051639
name: natriuretic peptides A O-glycosylated 1 (human)
def: "A natriuretic peptides A (human) that has been O-glycosylated at the residue equivalent to Ser-75 of the amino acid sequence represented by UniProtKB:P01160-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P01160-1, Ser-75, MOD:00002~GNO:G43417UB." [GlyGen:P01160-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hNPPA/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01160-1, Ser-75, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01160 ! natriuretic peptides A (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P05125
name: natriuretic peptides A (mouse)
def: "An atrial natriuretic factor that is encoded in the genome of mouse." [OMA:P05125, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pnd" RELATED Gene-based [UniProtKB:P05125]
synonym: "Nppa" RELATED Gene-based [UniProtKB:P05125]
synonym: "mNPPA" EXACT PRO-short-label [PRO:DNx]
synonym: "CDD (mouse)" EXACT [UniProtKB:P05125]
synonym: "proANF (mouse)" EXACT [UniProtKB:P05125]
synonym: "proANP (mouse)" EXACT [UniProtKB:P05125]
synonym: "preproANF (mouse)" EXACT [UniProtKB:P05125]
synonym: "preproANP (mouse)" EXACT [UniProtKB:P05125]
synonym: "atriopeptigen (mouse)" EXACT [UniProtKB:P05125]
synonym: "cardiodilatin (mouse)" EXACT [UniProtKB:P05125]
synonym: "preproCDD-ANF (mouse)" EXACT [UniProtKB:P05125]
synonym: "atrial natriuretic factor prohormone (mouse)" EXACT [UniProtKB:P05125]
synonym: "atrial natriuretic peptide prohormone (mouse)" EXACT [UniProtKB:P05125]
xref: UniProtKB:P05125
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000011374 ! atrial natriuretic factor
relationship: has_gene_template MGI:97367 ! Nppa (mouse)

[Term]
id: PR:P01161-1
name: natriuretic peptides A isoform 1 (rat)
def: "An atrial natriuretic factor isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rNPPA/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01161-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038666 ! atrial natriuretic factor isoform 1

[Term]
id: PR:000020774
name: atrial natriuretic factor, signal peptide removed form
def: "An atrial natriuretic factor that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "NPPA/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000011374 ! atrial natriuretic factor
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000020775
name: atrial natriuretic factor proteolytic cleavage product
def: "An atrial natriuretic factor that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "NPPA/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000011374 ! atrial natriuretic factor

[Term]
id: PR:000011374
name: atrial natriuretic factor
def: "A protein that is a translation product of the human NPPA gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "ANF" EXACT []
synonym: "ANP" RELATED Gene-based []
synonym: "CDD" EXACT []
synonym: "PND" RELATED Gene-based []
synonym: "NPPA" EXACT PRO-short-label [PRO:DNx]
synonym: "proANF" EXACT []
synonym: "proANP" EXACT []
synonym: "CDD-ANF" EXACT []
synonym: "preproANP" EXACT []
synonym: "atriopeptigen" EXACT []
synonym: "cardiodilatin" EXACT []
synonym: "preproCDD-ANF" EXACT []
synonym: "prepronatriodilatin" EXACT []
synonym: "atrial natriuretic peptide" EXACT []
synonym: "atrial natriuretic factor prohormone" EXACT []
synonym: "atrial natriuretic peptide prohormone" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P01160
name: natriuretic peptides A (human)
def: "An atrial natriuretic factor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P01160]
comment: Category=organism-gene.
synonym: "ANP" RELATED Gene-based [UniProtKB:P01160]
synonym: "PND" RELATED Gene-based [UniProtKB:P01160]
synonym: "NPPA" RELATED Gene-based [UniProtKB:P01160]
synonym: "hNPPA" EXACT PRO-short-label [PRO:DNx]
synonym: "CDD (human)" EXACT [UniProtKB:P01160]
synonym: "proANF (human)" EXACT [UniProtKB:P01160]
synonym: "proANP (human)" EXACT [UniProtKB:P01160]
synonym: "preproANP (human)" EXACT [UniProtKB:P01160]
synonym: "atriopeptigen (human)" EXACT [UniProtKB:P01160]
synonym: "cardiodilatin (human)" EXACT [UniProtKB:P01160]
synonym: "preproCDD-ANF (human)" EXACT [UniProtKB:P01160]
synonym: "atrial natriuretic factor prohormone (human)" EXACT [UniProtKB:P01160]
synonym: "atrial natriuretic peptide prohormone (human)" EXACT [UniProtKB:P01160]
xref: Reactome:R-HSA-976950 "PR:P01160 located_in GO:0005576"
xref: UniProtKB:P01160
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000011374 ! atrial natriuretic factor
relationship: has_gene_template HGNC:7939 ! NPPA (human)

[Term]
id: PR:000038666
name: atrial natriuretic factor isoform 1
def: "An atrial natriuretic factor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05125-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "NPPA/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000011374 ! atrial natriuretic factor