[Term]
id: PR:000036307
name: nucleophosmin acetylated 1 (human)
def: "A nucleophosmin that is N-terminal Met acetylated in human. Example: UniProtKB:P06748-1, Met-1, MOD:00058." [TDR:2341]
comment: Category=organism-modification. Note: Top down proteomics. Evidence=(ECO:0000006).
synonym: "hNPM1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06748-1, Met-1, MOD:00058" NARROW PRO-proteoform-std [PRO:DNx]
xref: TDR:2341
is_a: PR:000011370 ! nucleophosmin
relationship: has_part MOD:00058 ! N-acetyl-L-methionine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P06748-1
name: nucleophosmin isoform h1 (human)
def: "A nucleophosmin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06748-1." [PRO:DNx, UniProtKB:P06748]
comment: Category=organism-sequence.
synonym: "hNPM1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06748-1
is_a: PR:P06748 ! nucleophosmin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P06748-3
name: nucleophosmin isoform h3 (human)
def: "A nucleophosmin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06748-3." [PRO:DNx, UniProtKB:P06748]
comment: Category=organism-sequence.
synonym: "hNPM1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06748-3
is_a: PR:P06748 ! nucleophosmin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P06748-2
name: nucleophosmin isoform h2 (human)
def: "A nucleophosmin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06748-2." [PRO:DNx, UniProtKB:P06748]
comment: Category=organism-sequence.
synonym: "hNPM1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06748-2
is_a: PR:P06748 ! nucleophosmin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048628
name: nucleophosmin phosphorylated 2 (human)
def: "A nucleophosmin (human) that has been post-translationally modified to include phosphoserine at position 4 of the amino acid sequence represented by UniProtKB:P06748. UniProtKB:P06748, Ser-4, MOD:00046." [PRO:DNx, Reactome:R-HSA-6801679]
comment: Category=organism-modification.
synonym: "hNPM1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06748, Ser-4, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6801679 "PR:000048628 located_in GO:0005829"
is_a: PR:P06748 ! nucleophosmin (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045648
name: nucleophosmin phosphorylated 1 (human)
def: "A nucleophosmin (human) that has been phosphorylated at the position equivalent to Thr-199 of the amino acid sequence represented by UniProtKB:P06748-1. Example: UniProtKB:P06748-1, Thr-199, MOD:00047." [PMID:20333249, PMID:24998852, iPTMnet:P06748]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:20333249, PMID:24998852). Status=unreviewed.
synonym: "hNPM1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06748-1, Thr-199, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P06748 ! nucleophosmin (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000011370
name: nucleophosmin
def: "A protein that is a translation product of the human NPM1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "NPM" RELATED Gene-based []
synonym: "NPM1" EXACT PRO-short-label [PRO:DNx]
synonym: "numatrin" EXACT []
synonym: "nucleolar protein NO38" EXACT []
synonym: "nucleolar phosphoprotein B23" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P06748
name: nucleophosmin (human)
def: "A nucleophosmin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P06748]
comment: Category=organism-gene.
synonym: "NPM" RELATED Gene-based [UniProtKB:P06748]
synonym: "NPM1" RELATED Gene-based [UniProtKB:P06748]
synonym: "hNPM1" EXACT PRO-short-label [PRO:DNx]
synonym: "numatrin (human)" EXACT [UniProtKB:P06748]
synonym: "nucleolar protein NO38 (human)" EXACT [UniProtKB:P06748]
synonym: "nucleolar phosphoprotein B23 (human)" EXACT [UniProtKB:P06748]
xref: Reactome:R-HSA-606320 "PR:P06748 located_in GO:0005654"
xref: Reactome:R-HSA-3008211 "PR:P06748 located_in GO:0005829"
xref: UniProtKB:P06748
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000011370 ! nucleophosmin
relationship: has_gene_template HGNC:7910 ! NPM1 (human)