[Term]
id: PR:Q8R4B8
name: NACHT, LRR and PYD domains-containing protein 3 (mouse)
def: "A NACHT, LRR and PYD domains-containing protein 3 that is encoded in the genome of mouse." [OMA:Q8R4B8, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cias1" RELATED Gene-based [UniProtKB:Q8R4B8]
synonym: "Mmig1" RELATED Gene-based [UniProtKB:Q8R4B8]
synonym: "Nalp3" RELATED Gene-based [UniProtKB:Q8R4B8]
synonym: "Nlrp3" RELATED Gene-based [UniProtKB:Q8R4B8]
synonym: "Pypaf1" RELATED Gene-based [UniProtKB:Q8R4B8]
synonym: "mNLRP3" EXACT PRO-short-label [PRO:DNx]
synonym: "cryopyrin (mouse)" EXACT [UniProtKB:Q8R4B8]
synonym: "PYRIN-containing APAF1-like protein 1 (mouse)" EXACT [UniProtKB:Q8R4B8]
synonym: "cold autoinflammatory syndrome 1 protein homolog (mouse)" EXACT [UniProtKB:Q8R4B8]
synonym: "mast cell maturation-associated-inducible protein 1 (mouse)" EXACT [UniProtKB:Q8R4B8]
xref: UniProtKB:Q8R4B8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000011271 ! NACHT, LRR and PYD domains-containing protein 3
relationship: has_gene_template MGI:2653833 ! Nlrp3 (mouse)

[Term]
id: PR:Q96P20
name: NACHT, LRR and PYD domains-containing protein 3 (human)
def: "A NACHT, LRR and PYD domains-containing protein 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q96P20]
comment: Category=organism-gene.
synonym: "CIAS1" RELATED Gene-based [UniProtKB:Q96P20]
synonym: "NALP3" RELATED Gene-based [UniProtKB:Q96P20]
synonym: "NLRP3" RELATED Gene-based [UniProtKB:Q96P20]
synonym: "C1orf7" RELATED Gene-based [UniProtKB:Q96P20]
synonym: "PYPAF1" RELATED Gene-based [UniProtKB:Q96P20]
synonym: "hNLRP3" EXACT PRO-short-label [PRO:DNx]
synonym: "CLR1.1 (human)" EXACT [UniProtKB:Q96P20]
synonym: "cryopyrin (human)" EXACT [UniProtKB:Q96P20]
synonym: "caterpiller protein 1.1 (human)" EXACT [UniProtKB:Q96P20]
synonym: "PYRIN-containing APAF1-like protein 1 (human)" EXACT [UniProtKB:Q96P20]
synonym: "angiotensin/vasopressin receptor AII/AVP-like (human)" EXACT [UniProtKB:Q96P20]
synonym: "cold-induced autoinflammatory syndrome 1 protein (human)" EXACT [UniProtKB:Q96P20]
xref: UniProtKB:Q96P20
xref: Reactome:R-HSA-561189 "PR:Q96P20 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000011271 ! NACHT, LRR and PYD domains-containing protein 3
relationship: has_gene_template HGNC:16400 ! NLRP3 (human)

[Term]
id: PR:Q96P20-2
name: NACHT, LRR and PYD domains-containing protein 3 isoform h1 (human)
def: "A NACHT, LRR and PYD domains-containing protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P20-2." [PRO:DNx, UniProtKB:Q96P20]
comment: Category=organism-sequence.
synonym: "hNLRP3/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96P20-2
is_a: PR:Q96P20 ! NACHT, LRR and PYD domains-containing protein 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96P20-3
name: NACHT, LRR and PYD domains-containing protein 3 isoform h3 (human)
def: "A NACHT, LRR and PYD domains-containing protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P20-3." [PRO:DNx, UniProtKB:Q96P20]
comment: Category=organism-sequence.
synonym: "hNLRP3/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96P20-3
is_a: PR:Q96P20 ! NACHT, LRR and PYD domains-containing protein 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96P20-1
name: NACHT, LRR and PYD domains-containing protein 3 isoform h2 (human)
def: "A NACHT, LRR and PYD domains-containing protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P20-1." [PRO:DNx, UniProtKB:Q96P20]
comment: Category=organism-sequence.
synonym: "hNLRP3/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96P20-1
is_a: PR:Q96P20 ! NACHT, LRR and PYD domains-containing protein 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96P20-6
name: NACHT, LRR and PYD domains-containing protein 3 isoform h6 (human)
def: "A NACHT, LRR and PYD domains-containing protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P20-6." [PRO:DNx, UniProtKB:Q96P20]
comment: Category=organism-sequence.
synonym: "hNLRP3/iso:h6" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96P20-6
is_a: PR:Q96P20 ! NACHT, LRR and PYD domains-containing protein 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96P20-4
name: NACHT, LRR and PYD domains-containing protein 3 isoform h4 (human)
def: "A NACHT, LRR and PYD domains-containing protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P20-4." [PRO:DNx, UniProtKB:Q96P20]
comment: Category=organism-sequence.
synonym: "hNLRP3/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96P20-4
is_a: PR:Q96P20 ! NACHT, LRR and PYD domains-containing protein 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96P20-5
name: NACHT, LRR and PYD domains-containing protein 3 isoform h5 (human)
def: "A NACHT, LRR and PYD domains-containing protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P20-5." [PRO:DNx, UniProtKB:Q96P20]
comment: Category=organism-sequence.
synonym: "hNLRP3/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96P20-5
is_a: PR:Q96P20 ! NACHT, LRR and PYD domains-containing protein 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000011271
name: NACHT, LRR and PYD domains-containing protein 3
def: "A protein that is a translation product of the human NLRP3 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "CIAS1" RELATED Gene-based []
synonym: "Mmig1" RELATED Gene-based []
synonym: "NALP3" RELATED Gene-based []
synonym: "NLRP3" EXACT PRO-short-label [PRO:DNx]
synonym: "C1orf7" RELATED Gene-based []
synonym: "CLR1.1" EXACT []
synonym: "PYPAF1" RELATED Gene-based []
synonym: "cryopyrin" EXACT []
synonym: "caterpiller protein 1.1" EXACT []
synonym: "PYRIN-containing APAF1-like protein 1" EXACT []
synonym: "cold autoinflammatory syndrome 1 protein" EXACT []
synonym: "angiotensin/vasopressin receptor AII/AVP-like" EXACT []
synonym: "cold autoinflammatory syndrome 1 protein homolog" EXACT []
synonym: "mast cell maturation-associated-inducible protein 1" EXACT []
xref: IUPHARobj:1770
is_a: PR:000000001 ! protein

[Term]
id: PR:D4A523
name: NACHT, LRR and PYD domains-containing protein 3 (rat)
def: "A NACHT, LRR and PYD domains-containing protein 3 that is encoded in the genome of rat." [OMA:D4A523, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nalp3" RELATED Gene-based [UniProtKB:D4A523]
synonym: "Nlrp3" RELATED Gene-based [UniProtKB:D4A523]
synonym: "Pypaf1" RELATED Gene-based [UniProtKB:D4A523]
synonym: "rNLRP3" EXACT PRO-short-label [PRO:DNx]
synonym: "cryopyrin (rat)" EXACT [UniProtKB:D4A523]
synonym: "PYRIN-containing APAF1-like protein 1 (rat)" EXACT [UniProtKB:D4A523]
synonym: "cold autoinflammatory syndrome 1 protein homolog (rat)" EXACT [UniProtKB:D4A523]
synonym: "mast cell maturation-associated-inducible protein 1 (rat)" EXACT [UniProtKB:D4A523]
xref: UniProtKB:D4A523
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000011271 ! NACHT, LRR and PYD domains-containing protein 3
relationship: has_gene_template RGD:1308314 ! Nlrp3 (rat)

[Term]
id: PR:Q8R4B8-4
name: NACHT, LRR and PYD domains-containing protein 3 isoform m4 (mouse)
def: "A NACHT, LRR and PYD domains-containing protein 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R4B8-4." [PRO:DNx, UniProtKB:Q8R4B8]
comment: Category=organism-sequence.
synonym: "mNLRP3/iso:m4" EXACT PRO-short-label [PRO:DNx]
synonym: "NACHT, LRR and PYD domains-containing protein 3 isoform MMIG-1d (mouse)" EXACT [UniProtKB:Q8R4B8]
xref: UniProtKB:Q8R4B8-4
is_a: PR:Q8R4B8 ! NACHT, LRR and PYD domains-containing protein 3 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q8R4B8-3
name: NACHT, LRR and PYD domains-containing protein 3 isoform m3 (mouse)
def: "A NACHT, LRR and PYD domains-containing protein 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R4B8-3." [PRO:DNx, UniProtKB:Q8R4B8]
comment: Category=organism-sequence.
synonym: "mNLRP3/iso:m3" EXACT PRO-short-label [PRO:DNx]
synonym: "NACHT, LRR and PYD domains-containing protein 3 isoform MMIG-1c (mouse)" EXACT [UniProtKB:Q8R4B8]
xref: UniProtKB:Q8R4B8-3
is_a: PR:Q8R4B8 ! NACHT, LRR and PYD domains-containing protein 3 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q8R4B8-2
name: NACHT, LRR and PYD domains-containing protein 3 isoform m2 (mouse)
def: "A NACHT, LRR and PYD domains-containing protein 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R4B8-2." [PRO:DNx, UniProtKB:Q8R4B8]
comment: Category=organism-sequence.
synonym: "mNLRP3/iso:m2" EXACT PRO-short-label [PRO:DNx]
synonym: "NACHT, LRR and PYD domains-containing protein 3 isoform MMIG-1b (mouse)" EXACT [UniProtKB:Q8R4B8]
xref: UniProtKB:Q8R4B8-2
is_a: PR:Q8R4B8 ! NACHT, LRR and PYD domains-containing protein 3 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q8R4B8-1
name: NACHT, LRR and PYD domains-containing protein 3 isoform m1 (mouse)
def: "A NACHT, LRR and PYD domains-containing protein 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8R4B8-1." [PRO:DNx, UniProtKB:Q8R4B8]
comment: Category=organism-sequence.
synonym: "mNLRP3/iso:m1" EXACT PRO-short-label [PRO:DNx]
synonym: "NACHT, LRR and PYD domains-containing protein 3 isoform MMIG-1a (mouse)" EXACT [UniProtKB:Q8R4B8]
xref: UniProtKB:Q8R4B8-1
is_a: PR:Q8R4B8 ! NACHT, LRR and PYD domains-containing protein 3 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000048612
name: NACHT, LRR and PYD domains-containing protein 3 ubiquitinated form (human)
def: "A NACHT, LRR and PYD domains-containing protein 3 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q96P20, MOD:01148." [PRO:DNx, Reactome:R-HSA-6783288]
comment: Category=organism-modification.
synonym: "hNLRP3/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q96P20, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6783288 "PR:000048612 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:Q96P20 ! NACHT, LRR and PYD domains-containing protein 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens