[Term]
id: PR:P97526
name: neurofibromin (rat)
def: "A neurofibromin that is encoded in the genome of rat." [OMA:P97526, PANTHER:PTHR10194:SF7, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nf1" RELATED Gene-based [UniProtKB:P97526]
synonym: "rNF1" EXACT PRO-short-label [PRO:DNx]
synonym: "neurofibromatosis-related protein NF-1 (rat)" EXACT [UniProtKB:P97526]
xref: UniProtKB:P97526
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000011160 ! neurofibromin
relationship: has_gene_template RGD:3168 ! Nf1 (rat)

[Term]
id: PR:Q04690-2
name: neurofibromin isoform 1 (mouse)
def: "A neurofibromin isoform 2 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mNF1/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "neurofibromin isoform Type I (mouse)" EXACT [UniProtKB:Q04690]
xref: UniProtKB:Q04690-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000040266 ! neurofibromin isoform 2

[Term]
id: PR:Q04690
name: neurofibromin (mouse)
def: "A neurofibromin that is encoded in the genome of mouse." [OMA:Q04690, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nf1" RELATED Gene-based [UniProtKB:Q04690]
synonym: "mNF1" EXACT PRO-short-label [PRO:DNx]
synonym: "neurofibromatosis-related protein NF-1 (mouse)" EXACT [UniProtKB:Q04690]
xref: UniProtKB:Q04690
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000011160 ! neurofibromin
relationship: has_gene_template MGI:97306 ! Nf1 (mouse)

[Term]
id: PR:Q04690-4
name: neurofibromin isoform IV (mouse)
def: "A neurofibromin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04690-4." [PRO:DNx, UniProtKB:Q04690]
comment: Category=organism-sequence.
synonym: "mNF1/iso:IV" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q04690-4
is_a: PR:Q04690 ! neurofibromin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q04690-3
name: neurofibromin isoform III (mouse)
def: "A neurofibromin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04690-3." [PRO:DNx, UniProtKB:Q04690]
comment: Category=organism-sequence.
synonym: "mNF1/iso:III" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q04690-3
is_a: PR:Q04690 ! neurofibromin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P21359-4
name: neurofibromin isoform h4 (human)
def: "A neurofibromin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21359-4." [PRO:DNx, UniProtKB:P21359]
comment: Category=organism-sequence.
synonym: "hNF1/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P21359-4
is_a: PR:P21359 ! neurofibromin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P21359-5
name: neurofibromin isoform h5 (human)
def: "A neurofibromin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21359-5." [PRO:DNx, UniProtKB:P21359]
comment: Category=organism-sequence.
synonym: "hNF1/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P21359-5
is_a: PR:P21359 ! neurofibromin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000040266
name: neurofibromin isoform 2
def: "A neurofibromin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04690-2 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "NF1/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000011160 ! neurofibromin

[Term]
id: PR:P21359-1
name: neurofibromin isoform II (human)
def: "A neurofibromin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21359-1." [PRO:DNx, UniProtKB:P21359]
comment: Category=organism-sequence.
synonym: "hNF1/iso:II" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P21359-1
is_a: PR:P21359 ! neurofibromin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P21359-2
name: neurofibromin isoform I (human)
def: "A neurofibromin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21359-2." [PRO:DNx, UniProtKB:P21359]
comment: Category=organism-sequence.
synonym: "hNF1/iso:I" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P21359-2
is_a: PR:P21359 ! neurofibromin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P21359-3
name: neurofibromin isoform h3 (human)
def: "A neurofibromin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21359-3." [PRO:DNx, UniProtKB:P21359]
comment: Category=organism-sequence.
synonym: "hNF1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P21359-3
is_a: PR:P21359 ! neurofibromin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q04690-1
name: neurofibromin isoform II (mouse)
def: "A neurofibromin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04690-1." [PRO:DNx, UniProtKB:Q04690]
comment: Category=organism-sequence.
synonym: "mNF1/iso:II" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q04690-1
is_a: PR:Q04690 ! neurofibromin (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000048585
name: neurofibromin, initiator methionine removed ubiquitinated form (human)
def: "A neurofibromin (human) that has had the initiator methionine removed and that includes at least one ubiquitinated lysine. UniProtKB:P21359, 2-2839, MOD:01148." [PRO:DNx, Reactome:R-HSA-5658418]
comment: Category=organism-modification.
synonym: "hNF1/InitMet-/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000010773, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P21359, 2-2839, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5658418 "PR:000048585 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P21359 ! neurofibromin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048584
name: neurofibromin, initiator methionine removed form (human)
def: "A neurofibromin (human) that has had the initiator methionine removed. UniProtKB:P21359, 2-2839." [PRO:DNx, Reactome:R-HSA-947770]
comment: Category=organism-modification.
synonym: "hNF1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000010773" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P21359, 2-2839" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-947770 "PR:000048584 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P21359 ! neurofibromin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P21359
name: neurofibromin (human)
def: "A neurofibromin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P21359]
comment: Category=organism-gene.
synonym: "NF1" RELATED Gene-based [UniProtKB:P21359]
synonym: "hNF1" EXACT PRO-short-label [PRO:DNx]
synonym: "neurofibromatosis-related protein NF-1 (human)" EXACT [UniProtKB:P21359]
xref: UniProtKB:P21359
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000011160 ! neurofibromin
relationship: has_gene_template HGNC:7765 ! NF1 (human)

[Term]
id: PR:P97526-1
name: neurofibromin isoform 1 (rat)
def: "A neurofibromin isoform 2 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rNF1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P97526-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000040266 ! neurofibromin isoform 2

[Term]
id: PR:000011160
name: neurofibromin
def: "A protein that is a translation product of the human NF1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "NF1" EXACT PRO-short-label [PRO:DNx]
synonym: "neurofibromatosis-related protein NF-1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P21359-6
name: neurofibromin isoform h6 (human)
def: "A neurofibromin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21359-6." [PRO:DNx, UniProtKB:P21359]
comment: Category=organism-sequence.
synonym: "hNF1/iso:h6" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P21359-6
is_a: PR:P21359 ! neurofibromin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000020733
name: neurofibromin proteolytic cleavage product
def: "A neurofibromin that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "NF1/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000011160 ! neurofibromin