[Term]
id: PR:Q6R2P8
name: endonuclease 8-like 2 (mouse)
def: "An endonuclease 8-like 2 that is encoded in the genome of mouse." [OMA:Q6R2P8, PRO:DNx]
comment: Category=organism-gene.
synonym: "Neil2" RELATED Gene-based [UniProtKB:Q6R2P8]
synonym: "Gm1212" RELATED Gene-based [UniProtKB:Q6R2P8]
synonym: "mNEIL2" EXACT PRO-short-label [PRO:DNx]
synonym: "NEH2 (mouse)" EXACT [UniProtKB:Q6R2P8]
synonym: "Nei homolog 2 (mouse)" EXACT [UniProtKB:Q6R2P8]
synonym: "Nei-like protein 2 (mouse)" EXACT [UniProtKB:Q6R2P8]
synonym: "endonuclease VIII-like 2 (mouse)" EXACT [UniProtKB:Q6R2P8]
synonym: "DNA glycosylase/AP lyase Neil2 (mouse)" EXACT [UniProtKB:Q6R2P8]
synonym: "DNA-(apurinic or apyrimidinic site) lyase Neil2 (mouse)" EXACT [UniProtKB:Q6R2P8]
xref: UniProtKB:Q6R2P8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000011123 ! endonuclease 8-like 2
relationship: has_gene_template MGI:2686058 ! Neil2 (mouse)

[Term]
id: PR:Q969S2-4
name: endonuclease 8-like 2 isoform h4 (human)
def: "An endonuclease 8-like 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969S2-4." [PRO:DNx, UniProtKB:Q969S2]
comment: Category=organism-sequence.
synonym: "hNEIL2/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q969S2-4
is_a: PR:Q969S2 ! endonuclease 8-like 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q969S2-2
name: endonuclease 8-like 2 isoform h2 (human)
def: "An endonuclease 8-like 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969S2-2." [PRO:DNx, UniProtKB:Q969S2]
comment: Category=organism-sequence.
synonym: "hNEIL2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q969S2-2
is_a: PR:Q969S2 ! endonuclease 8-like 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q969S2-3
name: endonuclease 8-like 2 isoform h3 (human)
def: "An endonuclease 8-like 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969S2-3." [PRO:DNx, UniProtKB:Q969S2]
comment: Category=organism-sequence.
synonym: "hNEIL2/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q969S2-3
is_a: PR:Q969S2 ! endonuclease 8-like 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000011123
name: endonuclease 8-like 2
def: "A protein that is a translation product of the human NEIL2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "NEH2" EXACT []
synonym: "NEIL2" EXACT PRO-short-label [PRO:DNx]
synonym: "Gm1212" RELATED Gene-based []
synonym: "Nei homolog 2" EXACT []
synonym: "Nei-like protein 2" EXACT []
synonym: "endonuclease VIII-like 2" EXACT []
synonym: "DNA glycosylase/AP lyase Neil2" EXACT []
synonym: "DNA-(apurinic or apyrimidinic site) lyase Neil2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000045372
name: endonuclease 8-like 2 isoform 1 unacetylated 1 (human)
def: "An endonuclease 8-like 2 isoform 1 (human) that lacks acetylation on Lys-50 and Lys-154. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, PR:000026291." [PMID:15175427, PRO:CNA]
comment: Category=organism-modification.
synonym: "hNEIL2/iso:1/UnAc:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "endonuclease 8-like 2 isoform 1 unmodified form (human)" EXACT []
is_a: PR:Q969S2-1 ! endonuclease 8-like 2 isoform 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q969S2-1
name: endonuclease 8-like 2 isoform 1 (human)
def: "An endonuclease 8-like 2 isoform 1 that is encoded in the genome of human." [PRO:PD]
comment: Category=organism-sequence.
synonym: "hNEIL2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q969S2-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028589 ! endonuclease 8-like 2 isoform 1

[Term]
id: PR:Q969S2
name: endonuclease 8-like 2 (human)
def: "An endonuclease 8-like 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q969S2]
comment: Category=organism-gene.
synonym: "NEIL2" RELATED Gene-based [UniProtKB:Q969S2]
synonym: "hNEIL2" EXACT PRO-short-label [PRO:DNx]
synonym: "NEH2 (human)" EXACT [UniProtKB:Q969S2]
synonym: "Nei homolog 2 (human)" EXACT [UniProtKB:Q969S2]
synonym: "Nei-like protein 2 (human)" EXACT [UniProtKB:Q969S2]
synonym: "endonuclease VIII-like 2 (human)" EXACT [UniProtKB:Q969S2]
synonym: "DNA glycosylase/AP lyase Neil2 (human)" EXACT [UniProtKB:Q969S2]
synonym: "DNA-(apurinic or apyrimidinic site) lyase Neil2 (human)" EXACT [UniProtKB:Q969S2]
xref: UniProtKB:Q969S2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000011123 ! endonuclease 8-like 2
relationship: has_gene_template HGNC:18956 ! NEIL2 (human)

[Term]
id: PR:000028590
name: endonuclease 8-like 2 isoform 1, initiator methionine removed form
def: "An endonuclease 8-like 2 isoform 1 that has had the initiator methionine removed." [PMID:12097317, PRO:CNA]
comment: Category=modification.
synonym: "NEIL2/iso:1/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:000028589 ! endonuclease 8-like 2 isoform 1

[Term]
id: PR:000028591
name: endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1
def: "An endonuclease 8-like 2 isoform 1, initiator methionine removed form that is acetylated. Example: UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]
comment: Category=modification.
synonym: "NEIL2 acetylated" RELATED []
synonym: "NEIL2/iso:1/InitMet-/Ac:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000028590 ! endonuclease 8-like 2 isoform 1, initiator methionine removed form
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000028592
name: endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 (human)
def: "An endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 in human. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]
comment: Category=organism-modification. Acetylase=("EP300"; PR:000007102).
synonym: "NEIL2 acetylated (human)" RELATED []
synonym: "hNEIL2/iso:1/InitMet-/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028591 ! endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000048574
name: endonuclease 8-like 2, initiator methionine removed form (human)
def: "An endonuclease 8-like 2 (human) that has had the initiator methionine removed. UniProtKB:Q969S2, 2-332." [PRO:DNx, Reactome:R-HSA-5649650]
comment: Category=organism-modification.
synonym: "PRO_0000170908" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hNEIL2/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q969S2, 2-332" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5649650 "PR:000048574 located_in GO:0005654"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q969S2 ! endonuclease 8-like 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000020726
name: endonuclease 8-like 2, initiator methionine removed form
def: "An endonuclease 8-like 2 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "NEIL2/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "endonuclease VIII-like 2, initiator methionine removed form" EXACT []
intersection_of: PR:000011123 ! endonuclease 8-like 2
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000028589
name: endonuclease 8-like 2 isoform 1
def: "An endonuclease 8-like 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969S2-1 or a 1:1 ortholog thereof." [KAT:Q969S2, PMID:15175427, PRO:PD]
comment: Category=sequence.
synonym: "NEIL2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000011123 ! endonuclease 8-like 2