[Term]
id: PR:Q92542
name: nicastrin (human)
def: "A nicastrin that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q92542]
comment: Category=organism-gene.
synonym: "NCSTN" RELATED Gene-based [UniProtKB:Q92542]
synonym: "hNCSTN" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA0253" RELATED Gene-based [UniProtKB:Q92542]
synonym: "UNQ1874/PRO4317" RELATED Gene-based [UniProtKB:Q92542]
xref: UniProtKB:Q92542
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000011049 ! nicastrin
relationship: has_gene_template HGNC:17091 ! NCSTN (human)

[Term]
id: PR:000011049
name: nicastrin
def: "A protein that is a translation product of the human NCSTN gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene. Requested by=Alzforum.
synonym: "NCSTN" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA0253" RELATED Gene-based []
synonym: "UNQ1874/PRO4317" RELATED Gene-based []
is_a: PR:000000001 ! protein

[Term]
id: PR:000048535
name: nicastrin, signal peptide removed form (human)
def: "A nicastrin (human) that has had the signal peptide removed. UniProtKB:Q92542, 34-709." [PRO:DNx, Reactome:R-HSA-2534241]
comment: Category=organism-modification.
synonym: "PRO_0000019681" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hNCSTN/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q92542, 34-709" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2534241 "PR:000048535 located_in GO:0005886"
xref: Reactome:R-HSA-6799220 "PR:000048535 located_in GO:0035577"
xref: Reactome:R-HSA-9010085 "PR:000048535 located_in GO:0010008"
intersection_of: PR:Q92542 ! nicastrin (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q92542-1
name: nicastrin isoform h1 (human)
def: "A nicastrin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92542-1." [PRO:DNx, UniProtKB:Q92542]
comment: Category=organism-sequence.
synonym: "hNCSTN/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92542-1
is_a: PR:Q92542 ! nicastrin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q92542-2
name: nicastrin isoform h2 (human)
def: "A nicastrin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92542-2." [PRO:DNx, UniProtKB:Q92542]
comment: Category=organism-sequence.
synonym: "hNCSTN/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92542-2
is_a: PR:Q92542 ! nicastrin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens