[Term]
id: PR:Q8GUM5
name: nicastrin (Arabidopsis thaliana)
def: "A nicastrin that is encoded in the genome of Arabidopsis thaliana." [PRO:DAN]
comment: Category=organism-gene.
synonym: "At-NCSTN" EXACT PRO-short-label [PRO:DNx]
synonym: "At3g52640" RELATED Gene-based [UniProtKB:Q8GUM5]
xref: UniProtKB:Q8GUM5
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000011049 ! nicastrin
relationship: has_gene_template Araport:AT3G52640 ! At3g52640 (Arabidopsis thaliana)

[Term]
id: PR:Q8CGU6-1
name: nicastrin isoform 1 (rat)
def: "A nicastrin isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rNCSTN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8CGU6-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000039843 ! nicastrin isoform 1

[Term]
id: PR:Q8CGU6-2
name: nicastrin isoform r2 (rat)
def: "A nicastrin (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CGU6-2." [PRO:DNx, UniProtKB:Q8CGU6]
comment: Category=organism-sequence.
synonym: "rNCSTN/iso:r2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8CGU6-2
is_a: PR:Q8CGU6 ! nicastrin (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q92542
name: nicastrin (human)
def: "A nicastrin that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q92542]
comment: Category=organism-gene.
synonym: "NCSTN" RELATED Gene-based [UniProtKB:Q92542]
synonym: "hNCSTN" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA0253" RELATED Gene-based [UniProtKB:Q92542]
synonym: "UNQ1874/PRO4317" RELATED Gene-based [UniProtKB:Q92542]
xref: UniProtKB:Q92542
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000011049 ! nicastrin
relationship: has_gene_template HGNC:17091 ! NCSTN (human)

[Term]
id: PR:Q92542-2
name: nicastrin isoform h2 (human)
def: "A nicastrin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92542-2." [PRO:DNx, UniProtKB:Q92542]
comment: Category=organism-sequence.
synonym: "hNCSTN/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92542-2
is_a: PR:Q92542 ! nicastrin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q92542-1
name: nicastrin isoform h1 (human)
def: "A nicastrin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92542-1." [PRO:DNx, UniProtKB:Q92542]
comment: Category=organism-sequence.
synonym: "hNCSTN/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92542-1
is_a: PR:Q92542 ! nicastrin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q23316
name: nicastrin (worm)
def: "A nicastrin that is encoded in the genome of worm." [OMA:Q23316, PANTHER:PTHR21092:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "aph-2" RELATED Gene-based [UniProtKB:Q23316]
synonym: "ZC434.6" RELATED Gene-based [UniProtKB:Q23316]
synonym: "NCSTN (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "anterior-pharynx-defective protein 2 (worm)" EXACT [UniProtKB:Q23316]
xref: UniProtKB:Q23316
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000011049 ! nicastrin
relationship: has_gene_template WormBase:WBGene00000148 ! aph-2 (worm)

[Term]
id: PR:000039843
name: nicastrin isoform 1
def: "A nicastrin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P57716-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "NCSTN/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000011049 ! nicastrin

[Term]
id: PR:Q8CGU6
name: nicastrin (rat)
def: "A nicastrin that is encoded in the genome of rat." [OMA:Q8CGU6, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ncstn" RELATED Gene-based [UniProtKB:Q8CGU6]
synonym: "rNCSTN" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8CGU6
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000011049 ! nicastrin
relationship: has_gene_template RGD:631418 ! Ncstn (rat)

[Term]
id: PR:000011049
name: nicastrin
def: "A protein that is a translation product of the human NCSTN gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene. Requested by=Alzforum.
synonym: "NCSTN" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA0253" RELATED Gene-based []
synonym: "UNQ1874/PRO4317" RELATED Gene-based []
is_a: PR:000000001 ! protein

[Term]
id: PR:000059460
name: nicastrin N-glycosylated 4 (rat)
def: "A nicastrin (rat) that has been N-glycosylated at the residue equivalent to Asn-434 of the amino acid sequence represented by UniProtKB:Q8CGU6-1, in which the glycan structure is represented by GlyTouCan:G37135JQ. Example: UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G37135JQ." [GlyGen:Q8CGU6-1, PMID:24090084, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "rNCSTN/NGlyco:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G37135JQ" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~UniCarbKB:3869" NARROW [PRO:DNx]
is_a: PR:Q8CGU6 ! nicastrin (rat)
relationship: has_part GNO:G37135JQ ! G37135JQ
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000059461
name: nicastrin N-glycosylated 5 (rat)
def: "A nicastrin (rat) that has been N-glycosylated at the residue equivalent to Asn-434 of the amino acid sequence represented by UniProtKB:Q8CGU6-1, in which the glycan structure is represented by GlyTouCan:G60230HH. Example: UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G60230HH." [GlyGen:Q8CGU6-1, PMID:24090084, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "rNCSTN/NGlyco:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G60230HH" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~UniCarbKB:1081" NARROW [PRO:DNx]
is_a: PR:Q8CGU6 ! nicastrin (rat)
relationship: has_part GNO:G60230HH ! G60230HH
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q54JT7
name: nicastrin (Dictyostelium discoideum)
def: "A nicastrin that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54JT7, PANTHER:PTHR21092:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "ncstn" RELATED Gene-based [UniProtKB:Q54JT7]
synonym: "Dicty-NCSTN" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0287801" RELATED Gene-based [UniProtKB:Q54JT7]
xref: UniProtKB:Q54JT7
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000011049 ! nicastrin
relationship: has_gene_template dictyBase:DDB_G0287801 ! ncstn (Dictyostelium discoideum)

[Term]
id: PR:000059463
name: nicastrin N-glycosylated 7 (rat)
def: "A nicastrin (rat) that has been N-glycosylated at the residue equivalent to Asn-434 of the amino acid sequence represented by UniProtKB:Q8CGU6-1, in which the glycan composition is represented by GlyTouCan:G80920RR. Example: UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G80920RR." [GlyGen:Q8CGU6-1, PMID:24090084, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "rNCSTN/NGlyco:7" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G80920RR" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q8CGU6 ! nicastrin (rat)
relationship: has_part GNO:G80920RR ! G80920RR
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P57716-1
name: nicastrin isoform 1 (mouse)
def: "A nicastrin isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mNCSTN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P57716-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039843 ! nicastrin isoform 1

[Term]
id: PR:000059462
name: nicastrin N-glycosylated 6 (rat)
def: "A nicastrin (rat) that has been N-glycosylated at the residue equivalent to Asn-434 of the amino acid sequence represented by UniProtKB:Q8CGU6-1, in which the glycan composition is represented by GlyTouCan:G62765YT. Example: UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G62765YT." [GlyGen:Q8CGU6-1, PMID:24090084, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "rNCSTN/NGlyco:6" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G62765YT" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q8CGU6 ! nicastrin (rat)
relationship: has_part GNO:G62765YT ! G62765YT
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P57716
name: nicastrin (mouse)
def: "A nicastrin that is encoded in the genome of mouse." [OMA:P57716, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ncstn" RELATED Gene-based [UniProtKB:P57716]
synonym: "mNCSTN" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P57716
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000011049 ! nicastrin
relationship: has_gene_template MGI:1891700 ! Ncstn (mouse)

[Term]
id: PR:Q8GUM5-1
name: nicastrin isoform 1 (Arabidopsis thaliana)
def: "A nicastrin (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8GUM5-1." [PRO:DNx, UniProtKB:Q8GUM5]
comment: Category=organism-sequence.
synonym: "At-NCSTN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8GUM5-1
is_a: PR:Q8GUM5 ! nicastrin (Arabidopsis thaliana)
relationship: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana

[Term]
id: PR:000059459
name: nicastrin N-glycosylated 3 (rat)
def: "A nicastrin (rat) that has been N-glycosylated at the residue equivalent to Asn-434 of the amino acid sequence represented by UniProtKB:Q8CGU6-1, in which the glycan composition is represented by GlyTouCan:G31852PQ. Example: UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G31852PQ." [GlyGen:Q8CGU6-1, PMID:24090084, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "rNCSTN/NGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G31852PQ" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q8CGU6 ! nicastrin (rat)
relationship: has_part GNO:G31852PQ ! G31852PQ
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000059458
name: nicastrin N-glycosylated 2 (rat)
def: "A nicastrin (rat) that has been N-glycosylated at the residue equivalent to Asn-434 of the amino acid sequence represented by UniProtKB:Q8CGU6-1, in which the glycan structure is represented by GlyTouCan:G14548ZL. Example: UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G14548ZL." [GlyGen:Q8CGU6-1, PMID:24090084, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "rNCSTN/NGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G14548ZL" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~UniCarbKB:7924" NARROW [PRO:DNx]
is_a: PR:Q8CGU6 ! nicastrin (rat)
relationship: has_part GNO:G14548ZL ! G14548ZL
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000059457
name: nicastrin N-glycosylated 1 (rat)
def: "A nicastrin (rat) that has been N-glycosylated at the residue equivalent to Asn-434 of the amino acid sequence represented by UniProtKB:Q8CGU6-1, in which the glycan structure is represented by GlyTouCan:G09775CH. Example: UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G09775CH." [GlyGen:Q8CGU6-1, PMID:24090084, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "rNCSTN/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~GNO:G09775CH" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:Q8CGU6-1, Asn-434, MOD:00160~UniCarbKB:7896" NARROW [PRO:DNx]
is_a: PR:Q8CGU6 ! nicastrin (rat)
relationship: has_part GNO:G09775CH ! G09775CH
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q9VC27
name: nicastrin (fruit fly)
def: "A nicastrin that is encoded in the genome of fruit fly." [OMA:Q9VC27, PANTHER:PTHR21092:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nct" RELATED Gene-based [UniProtKB:Q9VC27]
synonym: "NCSTN" RELATED Gene-based [UniProtKB:Q9VC27]
synonym: "CG7012" RELATED Gene-based [UniProtKB:Q9VC27]
synonym: "fly-NCSTN" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9VC27
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000011049 ! nicastrin
relationship: has_gene_template FlyBase:FBgn0039234 ! Nct (fruit fly)

[Term]
id: PR:000048535
name: nicastrin, signal peptide removed form (human)
def: "A nicastrin (human) that has had the signal peptide removed. UniProtKB:Q92542, 34-709." [PRO:DNx, Reactome:R-HSA-2534241]
comment: Category=organism-modification.
synonym: "PRO_0000019681" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hNCSTN/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q92542, 34-709" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2534241 "PR:000048535 located_in GO:0005886"
xref: Reactome:R-HSA-6799220 "PR:000048535 located_in GO:0035577"
xref: Reactome:R-HSA-9010085 "PR:000048535 located_in GO:0010008"
intersection_of: PR:Q92542 ! nicastrin (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens