[Term]
id: PR:Q8L539-1
name: 5-formyltetrahydrofolate cyclo-ligase, mitochondrial isoform 1 (Arabidopsis thaliana)
def: "A 5-formyltetrahydrofolate cyclo-ligase, mitochondrial (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8L539-1." [PRO:DNx, UniProtKB:Q8L539]
comment: Category=organism-sequence.
synonym: "At-MTHFS/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8L539-1
is_a: PR:Q8L539 ! 5-formyltetrahydrofolate cyclo-ligase, mitochondrial (Arabidopsis thaliana)
relationship: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana

[Term]
id: PR:P40099
name: 5-formyltetrahydrofolate cyclo-ligase (yeast)
def: "A 5-formyltetrahydrofolate cyclo-ligase MTHFS that is encoded in the genome of yeast." [OMA:P40099, PANTHER:PTHR23407:SF1, PRO:DNx]
comment: Category=organism-gene.
synonym: "FAU1" RELATED Gene-based [UniProtKB:P40099]
synonym: "yMTHFS" EXACT PRO-short-label [PRO:DNx]
synonym: "YER183C" RELATED Gene-based [UniProtKB:P40099]
synonym: "MTHFS (yeast)" EXACT [UniProtKB:P40099]
synonym: "methenyl-THF synthetase (yeast)" EXACT [UniProtKB:P40099]
synonym: "5,10-methenyl-tetrahydrofolate synthetase (yeast)" EXACT [UniProtKB:P40099]
xref: UniProtKB:P40099
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000010726 ! 5-formyltetrahydrofolate cyclo-ligase MTHFS
relationship: has_gene_template SGD:S000000985 ! FAU1 (yeast)

[Term]
id: PR:Q9P7W2
name: probable 5-formyltetrahydrofolate cyclo-ligase (Schizosaccharomyces pombe 972h-)
def: "A 5-formyltetrahydrofolate cyclo-ligase MTHFS that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q9P7W2, PANTHER:PTHR23407:SF1, PRO:DNx]
comment: Category=organism-gene.
synonym: "SPBC1703.08c" RELATED Gene-based [UniProtKB:Q9P7W2]
synonym: "Spom972h-MTHFS" EXACT PRO-short-label [PRO:DNx]
synonym: "MTHFS (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q9P7W2]
synonym: "methenyl-THF synthetase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q9P7W2]
synonym: "5,10-methenyl-tetrahydrofolate synthetase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q9P7W2]
xref: UniProtKB:Q9P7W2
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000010726 ! 5-formyltetrahydrofolate cyclo-ligase MTHFS
relationship: has_gene_template PomBase:SPBC1703.08c ! SPBC1703.08c (Schizosaccharomyces pombe)

[Term]
id: PR:P49914-1
name: 5-formyltetrahydrofolate cyclo-ligase isoform h1 (human)
def: "A 5-formyltetrahydrofolate cyclo-ligase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49914-1." [PRO:DNx, UniProtKB:P49914]
comment: Category=organism-sequence.
synonym: "hMTHFS/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49914-1
is_a: PR:P49914 ! 5-formyltetrahydrofolate cyclo-ligase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49914-2
name: 5-formyltetrahydrofolate cyclo-ligase isoform h2 (human)
def: "A 5-formyltetrahydrofolate cyclo-ligase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49914-2." [PRO:DNx, UniProtKB:P49914]
comment: Category=organism-sequence.
synonym: "hMTHFS/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49914-2
is_a: PR:P49914 ! 5-formyltetrahydrofolate cyclo-ligase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49914
name: 5-formyltetrahydrofolate cyclo-ligase (human)
def: "A 5-formyltetrahydrofolate cyclo-ligase MTHFS that is encoded in the genome of human." [PRO:DNx, UniProtKB:P49914]
comment: Category=organism-gene.
synonym: "MTHFS" RELATED Gene-based [UniProtKB:P49914]
synonym: "hMTHFS" EXACT PRO-short-label [PRO:DNx]
synonym: "methenyl-THF synthetase (human)" EXACT [UniProtKB:P49914]
synonym: "5,10-methenyl-tetrahydrofolate synthetase (human)" EXACT [UniProtKB:P49914]
xref: UniProtKB:P49914
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010726 ! 5-formyltetrahydrofolate cyclo-ligase MTHFS
relationship: has_gene_template HGNC:7437 ! MTHFS (human)

[Term]
id: PR:Q8L539-2
name: 5-formyltetrahydrofolate cyclo-ligase, mitochondrial isoform 2 (Arabidopsis thaliana)
def: "A 5-formyltetrahydrofolate cyclo-ligase, mitochondrial (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8L539-2." [PRO:DNx, UniProtKB:Q8L539]
comment: Category=organism-sequence.
synonym: "At-MTHFS/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8L539-2
is_a: PR:Q8L539 ! 5-formyltetrahydrofolate cyclo-ligase, mitochondrial (Arabidopsis thaliana)
relationship: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana

[Term]
id: PR:000048471
name: 5-formyltetrahydrofolate cyclo-ligase, initiator methionine removed form (human)
def: "A 5-formyltetrahydrofolate cyclo-ligase (human) that has had the initiator methionine removed. UniProtKB:P49914, 2-203." [PRO:DNx, Reactome:R-HSA-6801331]
comment: Category=organism-modification.
synonym: "PRO_0000200275" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hMTHFS/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49914, 2-203" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6801331 "PR:000048471 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P49914 ! 5-formyltetrahydrofolate cyclo-ligase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9XWE6
name: probable 5-formyltetrahydrofolate cyclo-ligase (worm)
def: "A 5-formyltetrahydrofolate cyclo-ligase MTHFS that is encoded in the genome of worm." [OMA:Q9XWE6, PANTHER:PTHR23407:SF1, PRO:DNx]
comment: Category=organism-gene.
synonym: "Y106G6E.4" RELATED Gene-based [UniProtKB:Q9XWE6]
synonym: "MTHFS (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "methenyl-THF synthetase (worm)" EXACT [UniProtKB:Q9XWE6]
synonym: "5,10-methenyl-tetrahydrofolate synthetase (worm)" EXACT [UniProtKB:Q9XWE6]
xref: UniProtKB:Q9XWE6
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000010726 ! 5-formyltetrahydrofolate cyclo-ligase MTHFS
relationship: has_gene_template WormBase:WBGene00013708 ! Y106G6E.4 (worm)

[Term]
id: PR:000020649
name: 5-formyltetrahydrofolate cyclo-ligase MTHFS, initiator methionine removed form
def: "A 5-formyltetrahydrofolate cyclo-ligase MTHFS that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "MTHFS/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000010726 ! 5-formyltetrahydrofolate cyclo-ligase MTHFS
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:Q8L539
name: 5-formyltetrahydrofolate cyclo-ligase, mitochondrial (Arabidopsis thaliana)
def: "A 5-formyltetrahydrofolate cyclo-ligase MTHFS that is encoded in the genome of Arabidopsis thaliana." [OMA:Q8L539, PANTHER:PTHR23407:SF1, PRO:DNx]
comment: Category=organism-gene.
synonym: "5FCL" RELATED Gene-based [UniProtKB:Q8L539]
synonym: "At-MTHFS" EXACT PRO-short-label [PRO:DNx]
synonym: "T19L5.10" RELATED Gene-based [UniProtKB:Q8L539]
synonym: "At5g13050" RELATED Gene-based [UniProtKB:Q8L539]
synonym: "5-FCL (Arabidopsis thaliana)" EXACT [UniProtKB:Q8L539]
xref: UniProtKB:Q8L539
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000010726 ! 5-formyltetrahydrofolate cyclo-ligase MTHFS
relationship: has_gene_template Araport:AT5G13050 ! 5FCL (Arabidopsis thaliana)

[Term]
id: PR:000010726
name: 5-formyltetrahydrofolate cyclo-ligase MTHFS
def: "A protein that is a translation product of the human MTHFS gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MTHFS" EXACT PRO-short-label [PRO:DNx]
synonym: "methenyl-THF synthetase" EXACT []
synonym: "5,10-methenyl-tetrahydrofolate synthetase" EXACT []
is_a: PR:000000001 ! protein