[Term]
id: PR:P42898
name: methylenetetrahydrofolate reductase (human)
def: "A methylenetetrahydrofolate reductase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P42898]
comment: Category=organism-gene.
synonym: "MTHFR" RELATED Gene-based [UniProtKB:P42898]
synonym: "hMTHFR" EXACT PRO-short-label [PRO:DNx]
xref: Reactome:R-HSA-200663 "PR:P42898 located_in GO:0005829"
xref: UniProtKB:P42898
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010725 ! methylenetetrahydrofolate reductase
relationship: has_gene_template HGNC:7436 ! MTHFR (human)

[Term]
id: PR:P42898-1
name: methylenetetrahydrofolate reductase isoform h1 (human)
def: "A methylenetetrahydrofolate reductase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42898-1." [PRO:DNx, UniProtKB:P42898]
comment: Category=organism-sequence.
synonym: "hMTHFR/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P42898-1
is_a: PR:P42898 ! methylenetetrahydrofolate reductase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P42898-2
name: methylenetetrahydrofolate reductase isoform h2 (human)
def: "A methylenetetrahydrofolate reductase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42898-2." [PRO:DNx, UniProtKB:P42898]
comment: Category=organism-sequence.
synonym: "hMTHFR/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P42898-2
is_a: PR:P42898 ! methylenetetrahydrofolate reductase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000010725
name: methylenetetrahydrofolate reductase
def: "A protein that is a translation product of the human MTHFR gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MTHFR" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000001 ! protein