[Term]
id: PR:P42898
name: methylenetetrahydrofolate reductase (human)
def: "A methylenetetrahydrofolate reductase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P42898]
comment: Category=organism-gene.
synonym: "MTHFR" RELATED Gene-based [UniProtKB:P42898]
synonym: "hMTHFR" EXACT PRO-short-label [PRO:DNx]
xref: Reactome:R-HSA-200663 "PR:P42898 located_in GO:0005829"
xref: UniProtKB:P42898
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010725 ! methylenetetrahydrofolate reductase
relationship: has_gene_template HGNC:7436 ! MTHFR (human)

[Term]
id: PR:Q10258
name: methylenetetrahydrofolate reductase 1 (Schizosaccharomyces pombe 972h-)
def: "A methylenetetrahydrofolate reductase that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q10258, PANTHER:PTHR21091:SF1, PRO:DNx]
comment: Category=organism-gene.
synonym: "met9" RELATED Gene-based [UniProtKB:Q10258]
synonym: "SPAC56F8.10" RELATED Gene-based [UniProtKB:Q10258]
synonym: "Spom972h-MTHFR" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q10258
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000010725 ! methylenetetrahydrofolate reductase
relationship: has_gene_template PomBase:SPAC56F8.10 ! met9 (Schizosaccharomyces pombe)

[Term]
id: PR:Q17693
name: probable methylenetetrahydrofolate reductase (worm)
def: "A methylenetetrahydrofolate reductase that is encoded in the genome of worm." [OMA:Q17693, PANTHER:PTHR21091:SF1, PRO:DNx]
comment: Category=organism-gene.
synonym: "mthf-1" RELATED Gene-based [UniProtKB:Q17693]
synonym: "C06A8.1" RELATED Gene-based [UniProtKB:Q17693]
synonym: "MTHFR (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q17693
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000010725 ! methylenetetrahydrofolate reductase
relationship: has_gene_template WormBase:WBGene00015512 ! mthf-1 (worm)

[Term]
id: PR:Q17693-2
name: probable methylenetetrahydrofolate reductase isoform b (worm)
def: "A probable methylenetetrahydrofolate reductase (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q17693-2." [PRO:DNx, UniProtKB:Q17693]
comment: Category=organism-sequence.
synonym: "MTHFR/iso:b (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q17693-2
is_a: PR:Q17693 ! probable methylenetetrahydrofolate reductase (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:Q9VTI0
name: methylenetetrahydrofolate reductase (fruit fly)
def: "A methylenetetrahydrofolate reductase that is encoded in the genome of fruit fly." [PANTHER:PTHR21091:SF1, PRO:DNx]
comment: Category=organism-gene.
synonym: "fly-MTHFR" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9VTI0
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000010725 ! methylenetetrahydrofolate reductase
relationship: has_gene_template FlyBase:FBgn0036157 ! CG7560 (fruit fly)

[Term]
id: PR:Q9WU20
name: methylenetetrahydrofolate reductase (mouse)
def: "A methylenetetrahydrofolate reductase that is encoded in the genome of mouse." [OMA:Q9WU20, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mthfr" RELATED Gene-based [UniProtKB:Q9WU20]
synonym: "mMTHFR" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9WU20
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000010725 ! methylenetetrahydrofolate reductase
relationship: has_gene_template MGI:106639 ! Mthfr (mouse)

[Term]
id: PR:O80585
name: methylenetetrahydrofolate reductase 2 (Arabidopsis thaliana)
def: "A methylenetetrahydrofolate reductase that is encoded in the genome of Arabidopsis thaliana." [OMA:O80585, PANTHER:PTHR21091:SF1, PRO:DNx]
comment: Category=organism-gene.
synonym: "MTHFR2" RELATED Gene-based [UniProtKB:O80585]
synonym: "At-MTHFR" EXACT PRO-short-label [PRO:DNx]
synonym: "AtMTHFR2" EXACT [UniProtKB:O80585]
synonym: "F6E13.29" RELATED Gene-based [UniProtKB:O80585]
synonym: "At2g44160" RELATED Gene-based [UniProtKB:O80585]
xref: UniProtKB:O80585
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000010725 ! methylenetetrahydrofolate reductase
relationship: has_gene_template Araport:AT2G44160 ! MTHFR2 (Arabidopsis thaliana)

[Term]
id: PR:P42898-1
name: methylenetetrahydrofolate reductase isoform h1 (human)
def: "A methylenetetrahydrofolate reductase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42898-1." [PRO:DNx, UniProtKB:P42898]
comment: Category=organism-sequence.
synonym: "hMTHFR/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P42898-1
is_a: PR:P42898 ! methylenetetrahydrofolate reductase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q17693-1
name: probable methylenetetrahydrofolate reductase isoform a (worm)
def: "A probable methylenetetrahydrofolate reductase (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q17693-1." [PRO:DNx, UniProtKB:Q17693]
comment: Category=organism-sequence.
synonym: "MTHFR/iso:a (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q17693-1
is_a: PR:Q17693 ! probable methylenetetrahydrofolate reductase (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:P53128
name: methylenetetrahydrofolate reductase 2 (yeast)
def: "A methylenetetrahydrofolate reductase that is encoded in the genome of yeast." [OMA:P53128, PANTHER:PTHR21091:SF1, PRO:DNx]
comment: Category=organism-gene.
synonym: "G2882" RELATED Gene-based [UniProtKB:P53128]
synonym: "MET11" RELATED Gene-based [UniProtKB:P53128]
synonym: "MET13" RELATED Gene-based [UniProtKB:P53128]
synonym: "MRPL45" RELATED Gene-based [UniProtKB:P53128]
synonym: "yMTHFR" EXACT PRO-short-label [PRO:DNx]
synonym: "YGL125W" RELATED Gene-based [UniProtKB:P53128]
synonym: "YmL45 (yeast)" EXACT [UniProtKB:P53128]
xref: UniProtKB:P53128
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000010725 ! methylenetetrahydrofolate reductase
relationship: has_gene_template SGD:S000003093 ! MET13 (yeast)

[Term]
id: PR:P42898-2
name: methylenetetrahydrofolate reductase isoform h2 (human)
def: "A methylenetetrahydrofolate reductase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42898-2." [PRO:DNx, UniProtKB:P42898]
comment: Category=organism-sequence.
synonym: "hMTHFR/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P42898-2
is_a: PR:P42898 ! methylenetetrahydrofolate reductase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000010725
name: methylenetetrahydrofolate reductase
def: "A protein that is a translation product of the human MTHFR gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MTHFR" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000001 ! protein