[Term]
id: PR:P11586
name: C-1-tetrahydrofolate synthase, cytoplasmic (human)
def: "A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11586]
comment: Category=organism-gene.
synonym: "MTHFC" RELATED Gene-based [UniProtKB:P11586]
synonym: "MTHFD" RELATED Gene-based [UniProtKB:P11586]
synonym: "MTHFD1" RELATED Gene-based [UniProtKB:P11586]
synonym: "hMTHFD1" EXACT PRO-short-label [PRO:DNx]
synonym: "C1-THF synthase (human)" EXACT [UniProtKB:P11586]
synonym: "epididymis secretory sperm binding protein (human)" EXACT [UniProtKB:P11586]
xref: UniProtKB:P11586
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010722 ! C-1-tetrahydrofolate synthase, cytoplasmic
relationship: has_gene_template HGNC:7432 ! MTHFD1 (human)

[Term]
id: PR:P11586-1
name: C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 (human)
def: "A C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hMTHFD1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11586-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038850 ! C-1-tetrahydrofolate synthase, cytoplasmic isoform 1

[Term]
id: PR:000010722
name: C-1-tetrahydrofolate synthase, cytoplasmic
def: "A protein that is a translation product of the human MTHFD1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MTHFC" RELATED Gene-based []
synonym: "MTHFD" RELATED Gene-based []
synonym: "MTHFD1" EXACT PRO-short-label [PRO:DNx]
synonym: "C1-THF synthase" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000048468
name: C-1-tetrahydrofolate synthase, cytoplasmic, initiator methionine removed form (human)
def: "A C-1-tetrahydrofolate synthase, cytoplasmic (human) that has had the initiator methionine removed. UniProtKB:P11586, 2-935." [PRO:DNx, Reactome:R-HSA-200641]
comment: Category=organism-modification.
synonym: "PRO_0000199321" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hMTHFD1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P11586, 2-935" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-200641 "PR:000048468 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P11586 ! C-1-tetrahydrofolate synthase, cytoplasmic (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens