[Term]
id: PR:000045810
name: double-strand break repair protein MRE11 phosphorylated 1 (human)
def: "A double-strand break repair protein MRE11 (human) that has been phosphorylated at the position equivalent to Ser-649 of the amino acid sequence represented by UniProtKB:P49959-1. Example: UniProtKB:P49959-1, Ser-649, MOD:00046." [PMID:15845385, iPTMnet:P49959]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15845385). Status=unreviewed.
synonym: "hMRE11/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49959-1, Ser-649, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P49959 ! double-strand break repair protein MRE11 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49959
name: double-strand break repair protein MRE11 (human)
def: "A double-strand break repair protein MRE11 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "HNGS1" RELATED Gene-based [UniProtKB:P49959]
synonym: "MRE11" RELATED Gene-based [UniProtKB:P49959]
synonym: "MRE11A" RELATED Gene-based [UniProtKB:P49959]
synonym: "hMRE11" EXACT PRO-short-label [PRO:DNx]
synonym: "MRE11 homolog 1 (human)" EXACT [UniProtKB:P49959]
synonym: "MRE11 homolog A (human)" EXACT [UniProtKB:P49959]
synonym: "meiotic recombination 11 homolog 1 (human)" EXACT [UniProtKB:P49959]
synonym: "meiotic recombination 11 homolog A (human)" EXACT [UniProtKB:P49959]
synonym: "double-strand break repair protein MRE11A (human)" EXACT [PRO:DNx]
xref: Reactome:R-HSA-59544 "PR:P49959 located_in GO:0005654"
xref: Reactome:R-HSA-3204309 "PR:P49959 located_in GO:0005829"
xref: UniProtKB:P49959
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010562 ! double-strand break repair protein MRE11
relationship: has_gene_template HGNC:7230 ! MRE11 (human)

[Term]
id: PR:000010562
name: double-strand break repair protein MRE11
def: "A protein that is a translation product of the human MRE11 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "HNGS1" RELATED Gene-based []
synonym: "MRE11" EXACT PRO-short-label [PRO:DNx]
synonym: "MRE11A" RELATED Gene-based [PRO:DNx]
synonym: "MRE11 homolog 1" EXACT []
synonym: "MRE11 homolog A" EXACT []
synonym: "meiotic recombination 11 homolog 1" EXACT []
synonym: "meiotic recombination 11 homolog A" EXACT []
synonym: "double-strand break repair protein MRE11A" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P49959-1
name: double-strand break repair protein MRE11 isoform 1 (human)
def: "A double-strand break repair protein MRE11 isoform 1 that is encoded in the genome of human." [PMID:9651580, PRO:CNA]
comment: Category=organism-sequence.
synonym: "hMRE11/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "MRE11A isoform 1 (human)" EXACT [PRO:DNx]
synonym: "double-strand break repair protein MRE11A isoform 1 (human)" EXACT []
xref: UniProtKB:P49959-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027043 ! double-strand break repair protein MRE11 isoform 1

[Term]
id: PR:P49959-2
name: double-strand break repair protein MRE11 isoform h2 (human)
def: "A double-strand break repair protein MRE11 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49959-2." [PRO:DNx, UniProtKB:P49959]
comment: Category=organism-sequence.
synonym: "hMRE11/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49959-2
is_a: PR:P49959 ! double-strand break repair protein MRE11 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49959-3
name: double-strand break repair protein MRE11 isoform h3 (human)
def: "A double-strand break repair protein MRE11 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49959-3." [PRO:DNx, UniProtKB:P49959]
comment: Category=organism-sequence.
synonym: "hMRE11/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49959-3
is_a: PR:P49959 ! double-strand break repair protein MRE11 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens