[Term]
id: PR:000048387
name: carbohydrate-responsive element-binding protein phosphorylated 3 (human)
def: "A carbohydrate-responsive element-binding protein (human) that has been post-translationally modified to include phosphothreonine at position 653 of the amino acid sequence represented by UniProtKB:Q9NP71. UniProtKB:Q9NP71, Thr-653, MOD:00047." [PRO:DNx, Reactome:R-HSA-164349, Reactome:R-HSA-164365]
comment: Category=organism-modification. Note: The modified site indicated here (Thr-653) corresponds to Thr-666 of the rat sequence UniProtKB:Q8VIP2. [PRO:DAN, PMID:11698644]
synonym: "hMLXIPL/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9NP71, Thr-653, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-164349 "PR:000048387 located_in GO:0005654"
xref: Reactome:R-HSA-164365 "PR:000048387 located_in GO:0005829"
is_a: PR:Q9NP71 ! carbohydrate-responsive element-binding protein (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048386
name: carbohydrate-responsive element-binding protein phosphorylated 2 (human)
def: "A carbohydrate-responsive element-binding protein (human) that has been post-translationally modified to include phosphoserine at position 556 of the amino acid sequence represented by UniProtKB:Q9NP71. UniProtKB:Q9NP71, Ser-556, MOD:00046." [PRO:DAN, Reactome:R-HSA-163687]
comment: Category=organism-modification. Note: The modified site indicated here (Ser-556) is referred to as Ser-568 in the literature using the rat sequence. [PRO:DAN, PMID:11724780]
synonym: "hMLXIPL/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9NP71, Ser-556, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-163687 "PR:000048386 located_in GO:0005654"
is_a: PR:Q9NP71 ! carbohydrate-responsive element-binding protein (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048385
name: carbohydrate-responsive element-binding protein phosphorylated 1 (human)
def: "A carbohydrate-responsive element-binding protein (human) that has been post-translationally modified to include phosphoserine at position 196, and phosphothreonine at position 653 of the amino acid sequence represented by UniProtKB:Q9NP71. UniProtKB:Q9NP71, Ser-196, MOD:00046|Thr-653, MOD:00047." [PRO:DNx, Reactome:R-HSA-164351]
comment: Category=organism-modification. Note: The modified sites indicated here (Ser-196/Thr-653) corresponds to Ser-196/Thr-666 of the rat sequence UniProtKB:Q8VIP2. [PRO:DAN, PMID:11698644]
synonym: "hMLXIPL/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9NP71, Ser-196, MOD:00046|Thr-653, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-164351 "PR:000048385 located_in GO:0005829"
is_a: PR:Q9NP71 ! carbohydrate-responsive element-binding protein (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NP71-4
name: carbohydrate-responsive element-binding protein isoform h4 (human)
def: "A carbohydrate-responsive element-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NP71-4." [PRO:DNx, UniProtKB:Q9NP71]
comment: Category=organism-sequence.
synonym: "hMLXIPL/iso:h4" EXACT PRO-short-label [PRO:DNx]
synonym: "carbohydrate-responsive element-binding protein isoform Delta (human)" EXACT [UniProtKB:Q9NP71]
xref: UniProtKB:Q9NP71-4
is_a: PR:Q9NP71 ! carbohydrate-responsive element-binding protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NP71-5
name: carbohydrate-responsive element-binding protein isoform h5 (human)
def: "A carbohydrate-responsive element-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NP71-5." [PRO:DNx, UniProtKB:Q9NP71]
comment: Category=organism-sequence.
synonym: "hMLXIPL/iso:h5" EXACT PRO-short-label [PRO:DNx]
synonym: "carbohydrate-responsive element-binding protein isoform Epsilon (human)" EXACT [UniProtKB:Q9NP71]
xref: UniProtKB:Q9NP71-5
is_a: PR:Q9NP71 ! carbohydrate-responsive element-binding protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NP71-6
name: carbohydrate-responsive element-binding protein isoform h6 (human)
def: "A carbohydrate-responsive element-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NP71-6." [PRO:DNx, UniProtKB:Q9NP71]
comment: Category=organism-sequence.
synonym: "hMLXIPL/iso:h6" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9NP71-6
is_a: PR:Q9NP71 ! carbohydrate-responsive element-binding protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NP71-1
name: carbohydrate-responsive element-binding protein isoform h1 (human)
def: "A carbohydrate-responsive element-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NP71-1." [PRO:DNx, UniProtKB:Q9NP71]
comment: Category=organism-sequence.
synonym: "hMLXIPL/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "carbohydrate-responsive element-binding protein isoform Alpha (human)" EXACT [UniProtKB:Q9NP71]
xref: UniProtKB:Q9NP71-1
is_a: PR:Q9NP71 ! carbohydrate-responsive element-binding protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NP71-2
name: carbohydrate-responsive element-binding protein isoform h2 (human)
def: "A carbohydrate-responsive element-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NP71-2." [PRO:DNx, UniProtKB:Q9NP71]
comment: Category=organism-sequence.
synonym: "hMLXIPL/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "carbohydrate-responsive element-binding protein isoform Beta (human)" EXACT [UniProtKB:Q9NP71]
xref: UniProtKB:Q9NP71-2
is_a: PR:Q9NP71 ! carbohydrate-responsive element-binding protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NP71-3
name: carbohydrate-responsive element-binding protein isoform h3 (human)
def: "A carbohydrate-responsive element-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NP71-3." [PRO:DNx, UniProtKB:Q9NP71]
comment: Category=organism-sequence.
synonym: "hMLXIPL/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "carbohydrate-responsive element-binding protein isoform Gamma (human)" EXACT [UniProtKB:Q9NP71]
xref: UniProtKB:Q9NP71-3
is_a: PR:Q9NP71 ! carbohydrate-responsive element-binding protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NP71
name: carbohydrate-responsive element-binding protein (human)
def: "A carbohydrate-responsive element-binding protein that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "MIO" RELATED Gene-based [UniProtKB:Q9NP71]
synonym: "MLXIPL" RELATED Gene-based [UniProtKB:Q9NP71]
synonym: "BHLHD14" RELATED Gene-based [UniProtKB:Q9NP71]
synonym: "WBSCR14" RELATED Gene-based [UniProtKB:Q9NP71]
synonym: "hMLXIPL" EXACT PRO-short-label [PRO:DNx]
synonym: "ChREBP (human)" EXACT [UniProtKB:Q9NP71]
synonym: "WS-bHLH (human)" EXACT [UniProtKB:Q9NP71]
synonym: "MLX interactor (human)" EXACT [UniProtKB:Q9NP71]
synonym: "MLX-interacting protein-like (human)" EXACT [UniProtKB:Q9NP71]
synonym: "class D basic helix-loop-helix protein 14 (human)" EXACT [UniProtKB:Q9NP71]
synonym: "WS basic-helix-loop-helix leucine zipper protein (human)" EXACT [UniProtKB:Q9NP71]
synonym: "Williams-Beuren syndrome chromosomal region 14 protein (human)" EXACT [PRO:DNx]
xref: UniProtKB:Q9NP71
xref: Reactome:R-HSA-163683 "PR:Q9NP71 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010460 ! carbohydrate-responsive element-binding protein
relationship: has_gene_template HGNC:12744 ! MLXIPL (human)

[Term]
id: PR:000010460
name: carbohydrate-responsive element-binding protein
def: "A protein that is a translation product of the human MLXIPL gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MIO" RELATED Gene-based []
synonym: "ChREBP" EXACT []
synonym: "MLXIPL" EXACT PRO-short-label [PRO:DNx]
synonym: "BHLHD14" RELATED Gene-based []
synonym: "WBSCR14" RELATED Gene-based []
synonym: "WS-bHLH" EXACT []
synonym: "bHLHd14" EXACT []
synonym: "MLX interactor" EXACT []
synonym: "MLX-interacting protein-like" EXACT []
synonym: "class D basic helix-loop-helix protein 14" EXACT []
synonym: "WS basic-helix-loop-helix leucine zipper protein" EXACT []
synonym: "Williams-Beuren syndrome chromosomal region 14 protein" EXACT []
is_a: PR:000000001 ! protein