[Term] id: PR:Q14676-3 name: mediator of DNA damage checkpoint protein 1 isoform h3 (human) def: "A mediator of DNA damage checkpoint protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14676-3." [PRO:DNx, UniProtKB:Q14676] comment: Category=organism-sequence. synonym: "hMDC1/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q14676-3 is_a: PR:Q14676 ! mediator of DNA damage checkpoint protein 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q14676-2 name: mediator of DNA damage checkpoint protein 1 isoform h2 (human) def: "A mediator of DNA damage checkpoint protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14676-2." [PRO:DNx, UniProtKB:Q14676] comment: Category=organism-sequence. synonym: "hMDC1/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q14676-2 is_a: PR:Q14676 ! mediator of DNA damage checkpoint protein 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q14676-1 name: mediator of DNA damage checkpoint protein 1 isoform h1 (human) def: "A mediator of DNA damage checkpoint protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14676-1." [PRO:DNx, UniProtKB:Q14676] comment: Category=organism-sequence. synonym: "hMDC1/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q14676-1 is_a: PR:Q14676 ! mediator of DNA damage checkpoint protein 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q14676-4 name: mediator of DNA damage checkpoint protein 1 isoform h4 (human) def: "A mediator of DNA damage checkpoint protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14676-4." [PRO:DNx, UniProtKB:Q14676] comment: Category=organism-sequence. synonym: "hMDC1/iso:h4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q14676-4 is_a: PR:Q14676 ! mediator of DNA damage checkpoint protein 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048353 name: mediator of DNA damage checkpoint protein 1 phosphorylated 2 (human) def: "A mediator of DNA damage checkpoint protein 1 (human) that has been post-translationally modified to include phosphothreonine at positions 4, 699, 719, 752 and 765 of the amino acid sequence represented by UniProtKB:Q14676. UniProtKB:Q14676, Thr-4/Thr-699/Thr-719/Thr-752/Thr-765, MOD:00047." [PRO:DNx, Reactome:R-HSA-75236] comment: Category=organism-modification. synonym: "hMDC1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q14676, Thr-4/Thr-699/Thr-719/Thr-752/Thr-765, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-75236 "PR:000048353 located_in GO:0005654" is_a: PR:Q14676 ! mediator of DNA damage checkpoint protein 1 (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000045929 name: mediator of DNA damage checkpoint protein 1 phosphorylated 1 (human) def: "A mediator of DNA damage checkpoint protein 1 (human) that has been phosphorylated at the position equivalent to Thr-98 of the amino acid sequence represented by UniProtKB:Q14676-1. Example: UniProtKB:Q14676-1, Thr-98, MOD:00047." [PMID:21705321, iPTMnet:Q14676] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21705321). Status=unreviewed. synonym: "hMDC1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q14676-1, Thr-98, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:Q14676 ! mediator of DNA damage checkpoint protein 1 (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q14676 name: mediator of DNA damage checkpoint protein 1 (human) def: "A mediator of DNA damage checkpoint protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q14676] comment: Category=organism-gene. synonym: "MDC1" RELATED Gene-based [UniProtKB:Q14676] synonym: "NFBD1" RELATED Gene-based [UniProtKB:Q14676] synonym: "hMDC1" EXACT PRO-short-label [PRO:DNx] synonym: "KIAA0170" RELATED Gene-based [UniProtKB:Q14676] synonym: "nuclear factor with BRCT domains 1 (human)" EXACT [UniProtKB:Q14676] xref: UniProtKB:Q14676 xref: Reactome:R-HSA-75231 "PR:Q14676 located_in GO:0005654" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000010258 ! mediator of DNA damage checkpoint protein 1 relationship: has_gene_template HGNC:21163 ! MDC1 (human) [Term] id: PR:000010258 name: mediator of DNA damage checkpoint protein 1 def: "A protein that is a translation product of the human MDC1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "MDC1" EXACT PRO-short-label [PRO:DNx] synonym: "NFBD1" RELATED Gene-based [] synonym: "KIAA0170" RELATED Gene-based [] synonym: "nuclear factor with BRCT domains 1" EXACT [] is_a: PR:000000001 ! protein