[Term]
id: PR:000010167
name: MAP kinase-activated protein kinase 5
def: "A protein that is a translation product of the human MAPKAPK5 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PRAK" RELATED Gene-based []
synonym: "MAPKAPK5" EXACT PRO-short-label [PRO:DNx]
synonym: "MAPKAPK-5" EXACT []
synonym: "MAPKAP kinase 5" EXACT []
synonym: "MAPK-activated protein kinase 5" EXACT []
synonym: "p38-regulated/activated protein kinase" EXACT []
xref: IUPHARobj:2096
is_a: PR:000000001 ! protein

[Term]
id: PR:Q8IW41-2
name: MAP kinase-activated protein kinase 5 isoform 2 (human)
def: "A MAP kinase-activated protein kinase 5 isoform 2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hMAPKAPK5/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8IW41-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000041707 ! MAP kinase-activated protein kinase 5 isoform 2

[Term]
id: PR:Q8IW41-1
name: MAP kinase-activated protein kinase 5 isoform 1 (human)
def: "A MAP kinase-activated protein kinase 5 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hMAPKAPK5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8IW41-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000041706 ! MAP kinase-activated protein kinase 5 isoform 1

[Term]
id: PR:000048332
name: MAP kinase-activated protein kinase 5 phosphorylated 1 (human)
def: "A MAP kinase-activated protein kinase 5 (human) that has been post-translationally modified to include phosphoserine at position 115 of the amino acid sequence represented by UniProtKB:Q8IW41. UniProtKB:Q8IW41, Ser-115, MOD:00046." [PRO:DNx, Reactome:R-HSA-5687026, Reactome:R-HSA-5687028]
comment: Category=organism-modification.
synonym: "hMAPKAPK5/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8IW41, Ser-115, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5687026 "PR:000048332 located_in GO:0005654"
xref: Reactome:R-HSA-5687028 "PR:000048332 located_in GO:0005829"
is_a: PR:Q8IW41 ! MAP kinase-activated protein kinase 5 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048333
name: MAP kinase-activated protein kinase 5 phosphorylated 2 (human)
def: "A MAP kinase-activated protein kinase 5 (human) that has been post-translationally modified to include phosphothreonine at position 182 of the amino acid sequence represented by UniProtKB:Q8IW41. UniProtKB:Q8IW41, Thr-182, MOD:00047." [PRO:DNx, Reactome:R-HSA-3239018, Reactome:R-HSA-5687004]
comment: Category=organism-modification.
synonym: "hMAPKAPK5/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8IW41, Thr-182, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3239018 "PR:000048333 located_in GO:0005654"
xref: Reactome:R-HSA-5687004 "PR:000048333 located_in GO:0005829"
is_a: PR:Q8IW41 ! MAP kinase-activated protein kinase 5 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8IW41
name: MAP kinase-activated protein kinase 5 (human)
def: "A MAP kinase-activated protein kinase 5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8IW41]
comment: Category=organism-gene.
synonym: "PRAK" RELATED Gene-based [UniProtKB:Q8IW41]
synonym: "MAPKAPK5" RELATED Gene-based [UniProtKB:Q8IW41]
synonym: "hMAPKAPK5" EXACT PRO-short-label [PRO:DNx]
synonym: "MK5 (human)" EXACT [UniProtKB:Q8IW41]
synonym: "MK-5 (human)" EXACT [UniProtKB:Q8IW41]
synonym: "MAPKAP-K5 (human)" EXACT [UniProtKB:Q8IW41]
synonym: "MAPKAPK-5 (human)" EXACT [UniProtKB:Q8IW41]
synonym: "MAPKAP kinase 5 (human)" EXACT [UniProtKB:Q8IW41]
synonym: "MAPK-activated protein kinase 5 (human)" EXACT [UniProtKB:Q8IW41]
synonym: "p38-regulated/activated protein kinase (human)" EXACT [UniProtKB:Q8IW41]
xref: UniProtKB:Q8IW41
xref: Reactome:R-HSA-2562517 "PR:Q8IW41 located_in GO:0005654"
xref: DTO:03100301
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010167 ! MAP kinase-activated protein kinase 5
relationship: has_gene_template HGNC:6889 ! MAPKAPK5 (human)