[Term]
id: PR:Q99683-1
name: mitogen-activated protein kinase kinase kinase 5 isoform h1 (human)
def: "A mitogen-activated protein kinase kinase kinase 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99683-1." [PRO:DNx, UniProtKB:Q99683]
comment: Category=organism-sequence.
synonym: "hMAP3K5/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99683-1
is_a: PR:Q99683 ! mitogen-activated protein kinase kinase kinase 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q99683-2
name: mitogen-activated protein kinase kinase kinase 5 isoform h2 (human)
def: "A mitogen-activated protein kinase kinase kinase 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99683-2." [PRO:DNx, UniProtKB:Q99683]
comment: Category=organism-sequence.
synonym: "hMAP3K5/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99683-2
is_a: PR:Q99683 ! mitogen-activated protein kinase kinase kinase 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q21029
name: mitogen-activated protein kinase kinase kinase nsy-1 (worm)
def: "A mitogen-activated protein kinase kinase kinase 5 that is encoded in the genome of worm." [PRO:DNx]
comment: Category=organism-gene.
synonym: "nsy-1" RELATED Gene-based [UniProtKB:Q21029]
synonym: "F59A6.1" RELATED Gene-based [UniProtKB:Q21029]
synonym: "ASK-1 (worm)" EXACT [UniProtKB:Q21029]
synonym: "MAP3K5 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "neuronal symmetry kinase 1 (worm)" EXACT [UniProtKB:Q21029]
synonym: "apoptosis signal-regulating kinase 1 (worm)" EXACT [UniProtKB:Q21029]
xref: UniProtKB:Q21029
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000010138 ! mitogen-activated protein kinase kinase kinase 5
relationship: has_gene_template WormBase:WBGene00003822 ! nsy-1 (worm)

[Term]
id: PR:000010138
name: mitogen-activated protein kinase kinase kinase 5
def: "A protein that is a translation product of the human MAP3K5 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "ASK1" RELATED Gene-based []
synonym: "ASK-1" EXACT []
synonym: "MEKK5" RELATED Gene-based []
synonym: "MAP3K5" EXACT PRO-short-label [PRO:DNx]
synonym: "MEKK 5" EXACT []
synonym: "MAPKKK5" RELATED Gene-based []
synonym: "MEK kinase 5" EXACT []
synonym: "MAPK/ERK kinase kinase 5" EXACT []
synonym: "apoptosis signal-regulating kinase 1" EXACT []
xref: IUPHARobj:2080
is_a: PR:000000001 ! protein

[Term]
id: PR:000046036
name: mitogen-activated protein kinase kinase kinase 5 phosphorylated 1 (human)
def: "A mitogen-activated protein kinase kinase kinase 5 (human) that has been phosphorylated at the position equivalent to Ser-83 of the amino acid sequence represented by UniProtKB:Q99683-1. Example: UniProtKB:Q99683-1, Ser-83, MOD:00046." [PMID:11154276, PMID:12697749, PMID:14500571, PMID:15782121, PMID:19749799, iPTMnet:Q99683]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11154276, PMID:12697749, PMID:14500571, PMID:15782121, PMID:19749799). Status=unreviewed.
synonym: "hMAP3K5/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99683-1, Ser-83, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q99683 ! mitogen-activated protein kinase kinase kinase 5 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O35099
name: mitogen-activated protein kinase kinase kinase 5 (mouse)
def: "A mitogen-activated protein kinase kinase kinase 5 that is encoded in the genome of mouse." [OMA:O35099, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ask1" RELATED Gene-based [UniProtKB:O35099]
synonym: "Mekk5" RELATED Gene-based [UniProtKB:O35099]
synonym: "Map3k5" RELATED Gene-based [UniProtKB:O35099]
synonym: "mMAP3K5" EXACT PRO-short-label [PRO:DNx]
synonym: "ASK-1 (mouse)" EXACT [UniProtKB:O35099]
synonym: "MEKK 5 (mouse)" EXACT [UniProtKB:O35099]
synonym: "MEK kinase 5 (mouse)" EXACT [UniProtKB:O35099]
synonym: "MAPK/ERK kinase kinase 5 (mouse)" EXACT [UniProtKB:O35099]
synonym: "apoptosis signal-regulating kinase 1 (mouse)" EXACT [UniProtKB:O35099]
xref: UniProtKB:O35099
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000010138 ! mitogen-activated protein kinase kinase kinase 5
relationship: has_gene_template MGI:1346876 ! Map3k5 (mouse)

[Term]
id: PR:Q99683
name: mitogen-activated protein kinase kinase kinase 5 (human)
def: "A mitogen-activated protein kinase kinase kinase 5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q99683]
comment: Category=organism-gene.
synonym: "ASK1" RELATED Gene-based [UniProtKB:Q99683]
synonym: "MEKK5" RELATED Gene-based [UniProtKB:Q99683]
synonym: "MAP3K5" RELATED Gene-based [UniProtKB:Q99683]
synonym: "MAPKKK5" RELATED Gene-based [UniProtKB:Q99683]
synonym: "hMAP3K5" EXACT PRO-short-label [PRO:DNx]
synonym: "ASK-1 (human)" EXACT [UniProtKB:Q99683]
synonym: "MEKK 5 (human)" EXACT [UniProtKB:Q99683]
synonym: "MEK kinase 5 (human)" EXACT [UniProtKB:Q99683]
synonym: "MAPK/ERK kinase kinase 5 (human)" EXACT [UniProtKB:Q99683]
synonym: "apoptosis signal-regulating kinase 1 (human)" EXACT [UniProtKB:Q99683]
xref: UniProtKB:Q99683
xref: Reactome:R-HSA-167709 "PR:Q99683 located_in GO:0005829"
xref: DTO:03100287
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010138 ! mitogen-activated protein kinase kinase kinase 5
relationship: has_gene_template HGNC:6857 ! MAP3K5 (human)