[Term]
id: PR:Q90891
name: dual specificity mitogen-activated protein kinase kinase 2 (chicken)
def: "A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of chicken." [OMA:Q90891, PANTHER:PTHR24360:SF50, PRO:DNx]
comment: Category=organism-gene.
synonym: "MEK2" RELATED Gene-based [UniProtKB:Q90891]
synonym: "MKK2" RELATED Gene-based [UniProtKB:Q90891]
synonym: "MAP2K2" RELATED Gene-based [UniProtKB:Q90891]
synonym: "PRKMK2" RELATED Gene-based [UniProtKB:Q90891]
synonym: "chick-MAP2K2" EXACT PRO-short-label [PRO:DNx]
synonym: "MAPKK 2 (chicken)" EXACT [UniProtKB:Q90891]
synonym: "MAPK/ERK kinase 2 (chicken)" EXACT [UniProtKB:Q90891]
synonym: "MAP kinase kinase 2 (chicken)" EXACT [UniProtKB:Q90891]
synonym: "ERK activator kinase 2 (chicken)" EXACT [UniProtKB:Q90891]
xref: UniProtKB:Q90891
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000010126 ! dual specificity mitogen-activated protein kinase kinase 2
relationship: has_gene_template NCBIGene:396349 ! MAP2K2 (chicken)

[Term]
id: PR:000027056
name: dual specificity mitogen-activated protein kinase kinase 2 autophosphorylated form
def: "A dual specificity mitogen-activated protein kinase kinase 2 that has been post-translationally modified to include phosphorylated Ser and Thr residues by autocatalysis." [PMID:8388392]
comment: Category=modification.
synonym: "phospho-MEK2" EXACT []
synonym: "MAP2K2/Phos:auto" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00046 ! O-phospho-L-serine
intersection_of: has_part MOD:00047 ! O-phospho-L-threonine
intersection_of: PR:000010126 ! dual specificity mitogen-activated protein kinase kinase 2

[Term]
id: PR:000027057
name: dual specificity mitogen-activated protein kinase kinase 2 autophosphorylated form (human)
def: "A dual specificity mitogen-activated protein kinase kinase 2 autophosphorylated form in human." [PMID:8388392]
comment: Category=organism-modification.
synonym: "hMAP2K2/Phos:auto" EXACT PRO-short-label [PRO:DNx]
synonym: "human phospho-MEK2" EXACT []
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027056 ! dual specificity mitogen-activated protein kinase kinase 2 autophosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:P36507-1
name: dual specificity mitogen-activated protein kinase kinase 2 isoform 1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 2 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hMAP2K2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P36507-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039362 ! dual specificity mitogen-activated protein kinase kinase 2 isoform 1

[Term]
id: PR:000039362
name: dual specificity mitogen-activated protein kinase kinase 2 isoform 1
def: "A dual specificity mitogen-activated protein kinase kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36507-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "MAP2K2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000010126 ! dual specificity mitogen-activated protein kinase kinase 2

[Term]
id: PR:Q63932
name: dual specificity mitogen-activated protein kinase kinase 2 (mouse)
def: "A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of mouse." [OMA:Q63932, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mek2" RELATED Gene-based [UniProtKB:Q63932]
synonym: "Mkk2" RELATED Gene-based [UniProtKB:Q63932]
synonym: "Map2k2" RELATED Gene-based [UniProtKB:Q63932]
synonym: "Prkmk2" RELATED Gene-based [UniProtKB:Q63932]
synonym: "mMAP2K2" EXACT PRO-short-label [PRO:DNx]
synonym: "MEK 2 (mouse)" EXACT [UniProtKB:Q63932]
synonym: "MAPKK 2 (mouse)" EXACT [UniProtKB:Q63932]
synonym: "MAPK/ERK kinase 2 (mouse)" EXACT [UniProtKB:Q63932]
synonym: "MAP kinase kinase 2 (mouse)" EXACT [UniProtKB:Q63932]
synonym: "ERK activator kinase 2 (mouse)" EXACT [UniProtKB:Q63932]
xref: UniProtKB:Q63932
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000010126 ! dual specificity mitogen-activated protein kinase kinase 2
relationship: has_gene_template MGI:1346867 ! Map2k2 (mouse)

[Term]
id: PR:P36506-1
name: dual specificity mitogen-activated protein kinase kinase 2 isoform 1 (rat)
def: "A dual specificity mitogen-activated protein kinase kinase 2 isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rMAP2K2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P36506-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000039362 ! dual specificity mitogen-activated protein kinase kinase 2 isoform 1

[Term]
id: PR:000010126
name: dual specificity mitogen-activated protein kinase kinase 2
def: "A protein that is a translation product of the human MAP2K2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MEK2" RELATED Gene-based []
synonym: "MKK2" RELATED Gene-based []
synonym: "MEK 2" EXACT []
synonym: "MAP2K2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRKMK2" RELATED Gene-based []
synonym: "MAPKK 2" EXACT []
synonym: "MAPK/ERK kinase 2" EXACT []
synonym: "MAP kinase kinase 2" EXACT []
synonym: "ERK activator kinase 2" EXACT []
xref: IUPHARobj:2063
is_a: PR:000000001 ! protein

[Term]
id: PR:P36507
name: dual specificity mitogen-activated protein kinase kinase 2 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P36507]
comment: Category=organism-gene.
synonym: "MEK2" RELATED Gene-based [UniProtKB:P36507]
synonym: "MKK2" RELATED Gene-based [UniProtKB:P36507]
synonym: "MAP2K2" RELATED Gene-based [UniProtKB:P36507]
synonym: "PRKMK2" RELATED Gene-based [UniProtKB:P36507]
synonym: "hMAP2K2" EXACT PRO-short-label [PRO:DNx]
synonym: "MEK 2 (human)" EXACT [UniProtKB:P36507]
synonym: "MAPKK 2 (human)" EXACT [UniProtKB:P36507]
synonym: "MAPK/ERK kinase 2 (human)" EXACT [UniProtKB:P36507]
synonym: "MAP kinase kinase 2 (human)" EXACT [UniProtKB:P36507]
synonym: "ERK activator kinase 2 (human)" EXACT [UniProtKB:P36507]
xref: Reactome:R-HSA-59504 "PR:P36507 located_in GO:0005829"
xref: DTO:03100335
xref: UniProtKB:P36507
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010126 ! dual specificity mitogen-activated protein kinase kinase 2
relationship: has_gene_template HGNC:6842 ! MAP2K2 (human)

[Term]
id: PR:P36506
name: dual specificity mitogen-activated protein kinase kinase 2 (rat)
def: "A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of rat." [OMA:P36506, PANTHER:PTHR24360:SF50, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mek2" RELATED Gene-based [UniProtKB:P36506]
synonym: "Mkk2" RELATED Gene-based [UniProtKB:P36506]
synonym: "Map2k2" RELATED Gene-based [UniProtKB:P36506]
synonym: "Prkmk2" RELATED Gene-based [UniProtKB:P36506]
synonym: "rMAP2K2" EXACT PRO-short-label [PRO:DNx]
synonym: "MEK 2 (rat)" EXACT [UniProtKB:P36506]
synonym: "MAPKK 2 (rat)" EXACT [UniProtKB:P36506]
synonym: "MAPK/ERK kinase 2 (rat)" EXACT [UniProtKB:P36506]
synonym: "MAP kinase kinase 2 (rat)" EXACT [UniProtKB:P36506]
synonym: "ERK activator kinase 2 (rat)" EXACT [UniProtKB:P36506]
xref: UniProtKB:P36506
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000010126 ! dual specificity mitogen-activated protein kinase kinase 2
relationship: has_gene_template RGD:61888 ! Map2k2 (rat)

[Term]
id: PR:000048296
name: dual specificity mitogen-activated protein kinase kinase 2 phosphorylated 2 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 2 (human) that has been post-translationally modified to include phosphoserine at positions 222 and 226 of the amino acid sequence represented by UniProtKB:P36507. UniProtKB:P36507, Ser-222/Ser-226, MOD:00046." [PRO:DNx, Reactome:R-HSA-169292]
comment: Category=organism-modification.
synonym: "hMAP2K2/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36507, Ser-222/Ser-226, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-169292 "PR:000048296 located_in GO:0005829"
xref: Reactome:R-HSA-6802550 "PR:000048296 located_in GO:0005886"
is_a: PR:P36507 ! dual specificity mitogen-activated protein kinase kinase 2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens