[Term]
id: PR:000048292
name: dual specificity mitogen-activated protein kinase kinase 1, initiator methionine removed phosphorylated 1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 218 and 222 of the amino acid sequence represented by UniProtKB:Q02750. UniProtKB:Q02750, 2-393, Ser-218/Ser-222, MOD:00046." [PRO:DNx, Reactome:R-HSA-109837]
comment: Category=organism-modification.
synonym: "hMAP2K1/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000086365, Ser-218/Ser-222, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q02750, 2-393, Ser-218/Ser-222, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6802547 "PR:000048292 located_in GO:0005886"
xref: Reactome:R-HSA-109837 "PR:000048292 located_in GO:0005829"
is_a: PR:Q02750 ! dual specificity mitogen-activated protein kinase kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000026220
name: dual specificity mitogen-activated protein kinase kinase 1 isoform 1 phosphorylated 1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:Q02750-1, Ser-218/Ser-222, MOD:00046." [PMID:8131746, PRO:CNA]
comment: Category=organism-modification.
synonym: "hMAP2K1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q02750-1, Ser-218/Ser-222, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026196 ! dual specificity mitogen-activated protein kinase kinase 1 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:Q02750
name: dual specificity mitogen-activated protein kinase kinase 1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q02750]
comment: Category=organism-gene.
synonym: "MEK1" RELATED Gene-based [UniProtKB:Q02750]
synonym: "MAP2K1" RELATED Gene-based [UniProtKB:Q02750]
synonym: "PRKMK1" RELATED Gene-based [UniProtKB:Q02750]
synonym: "hMAP2K1" EXACT PRO-short-label [PRO:DNx]
synonym: "MKK1 (human)" EXACT [UniProtKB:Q02750]
synonym: "MEK 1 (human)" EXACT [UniProtKB:Q02750]
synonym: "MAPKK 1 (human)" EXACT [UniProtKB:Q02750]
synonym: "MAPK/ERK kinase 1 (human)" EXACT [UniProtKB:Q02750]
synonym: "MAP kinase kinase 1 (human)" EXACT [UniProtKB:Q02750]
synonym: "ERK activator kinase 1 (human)" EXACT [UniProtKB:Q02750]
xref: DTO:03100334
xref: UniProtKB:Q02750
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010125 ! dual specificity mitogen-activated protein kinase kinase 1
relationship: has_gene_template HGNC:6840 ! MAP2K1 (human)

[Term]
id: PR:Q02750-1
name: dual specificity mitogen-activated protein kinase kinase 1 isoform 1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNx]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hMAP2K1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q02750-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026194 ! dual specificity mitogen-activated protein kinase kinase 1 isoform 1

[Term]
id: PR:Q02750-2
name: dual specificity mitogen-activated protein kinase kinase 1 isoform h2 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02750-2." [PRO:DNx, UniProtKB:Q02750]
comment: Category=organism-sequence.
synonym: "hMAP2K1/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "dual specificity mitogen-activated protein kinase kinase 1 isoform MKK1b (human)" EXACT [UniProtKB:Q02750]
xref: UniProtKB:Q02750-2
is_a: PR:Q02750 ! dual specificity mitogen-activated protein kinase kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048291
name: dual specificity mitogen-activated protein kinase kinase 1, initiator methionine removed form (human)
def: "A dual specificity mitogen-activated protein kinase kinase 1 (human) that has had the initiator methionine removed. UniProtKB:Q02750, 2-393." [PRO:DNx, Reactome:R-HSA-59502]
comment: Category=organism-modification.
synonym: "PRO_0000086365" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hMAP2K1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q02750, 2-393" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-59502 "PR:000048291 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q02750 ! dual specificity mitogen-activated protein kinase kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045873
name: dual specificity mitogen-activated protein kinase kinase 1 phosphorylated 1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 1 (human) that has been phosphorylated at the position equivalent to Ser-298 of the amino acid sequence represented by UniProtKB:Q02750-1. Example: UniProtKB:Q02750-1, Ser-298, MOD:00046." [PMID:11948406, PMID:18593598, iPTMnet:Q02750]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11948406, PMID:18593598). Status=unreviewed.
synonym: "hMAP2K1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q02750-1, Ser-298, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q02750 ! dual specificity mitogen-activated protein kinase kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048293
name: dual specificity mitogen-activated protein kinase kinase 1, initiator methionine removed phosphorylated 2 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 218 and 222, and phosphothreonine at positions 286 and 292 of the amino acid sequence represented by UniProtKB:Q02750. UniProtKB:Q02750, 2-393, Ser-218/Ser-222, MOD:00046|Thr-286/Thr-292, MOD:00047." [PRO:DNx, Reactome:R-HSA-112339]
comment: Category=organism-modification.
synonym: "hMAP2K1/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000086365, Ser-218/Ser-222, MOD:00046|Thr-286/Thr-292, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q02750, 2-393, Ser-218/Ser-222, MOD:00046|Thr-286/Thr-292, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-112339 "PR:000048293 located_in GO:0005829"
is_a: PR:Q02750 ! dual specificity mitogen-activated protein kinase kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000010125
name: dual specificity mitogen-activated protein kinase kinase 1
def: "A protein that is a translation product of the human MAP2K1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MEK1" RELATED Gene-based []
synonym: "MEK 1" EXACT []
synonym: "MAP2K1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRKMK1" RELATED Gene-based []
synonym: "MAPKK 1" EXACT []
synonym: "MAPK/ERK kinase 1" EXACT []
synonym: "MAP kinase kinase 1" EXACT []
synonym: "ERK activator kinase 1" EXACT []
xref: IUPHARobj:2062
is_a: PR:000000001 ! protein

[Term]
id: PR:000048295
name: dual specificity mitogen-activated protein kinase kinase 1, initiator methionine removed phosphorylated 4 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at positions 286 and 292 of the amino acid sequence represented by UniProtKB:Q02750. UniProtKB:Q02750, 2-393, Thr-286/Thr-292, MOD:00047." [PRO:DNx, Reactome:R-HSA-112374]
comment: Category=organism-modification.
synonym: "hMAP2K1/InitMet-/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000086365, Thr-286/Thr-292, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q02750, 2-393, Thr-286/Thr-292, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-112374 "PR:000048295 located_in GO:0005829"
is_a: PR:Q02750 ! dual specificity mitogen-activated protein kinase kinase 1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000048294
name: dual specificity mitogen-activated protein kinase kinase 1, initiator methionine removed phosphorylated 3 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 218 and 222, and phosphothreonine at position 292 of the amino acid sequence represented by UniProtKB:Q02750. UniProtKB:Q02750, 2-393, Ser-218/Ser-222, MOD:00046|Thr-292, MOD:00047." [PRO:DNx, Reactome:R-HSA-5674490]
comment: Category=organism-modification.
synonym: "hMAP2K1/InitMet-/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000086365, Ser-218/Ser-222, MOD:00046|Thr-292, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q02750, 2-393, Ser-218/Ser-222, MOD:00046|Thr-292, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5674490 "PR:000048294 located_in GO:0005829"
is_a: PR:Q02750 ! dual specificity mitogen-activated protein kinase kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine