[Term]
id: PR:000010106
name: alpha-mannosidase 2x
def: "A protein that is a translation product of the human MAN2A2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MAN2A2" EXACT PRO-short-label [PRO:DNx]
synonym: "MANA2X" RELATED Gene-based []
synonym: "Man IIx" EXACT []
synonym: "alpha-mannosidase IIx" EXACT []
synonym: "mannosidase alpha class 2A member 2" EXACT []
synonym: "mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase" BROAD [PRO:DNx]
is_a: PR:000000001 ! protein

[Term]
id: PR:P49641
name: alpha-mannosidase 2x (human)
def: "An alpha-mannosidase 2x that is encoded in the genome of human." [PRO:DNx, UniProtKB:P49641]
comment: Category=organism-gene.
synonym: "MAN2A2" RELATED Gene-based [UniProtKB:P49641]
synonym: "MANA2X" RELATED Gene-based [UniProtKB:P49641]
synonym: "hMAN2A2" EXACT PRO-short-label [PRO:DNx]
synonym: "Man IIx (human)" EXACT [UniProtKB:P49641]
synonym: "alpha-mannosidase IIx (human)" EXACT [UniProtKB:P49641]
synonym: "mannosidase alpha class 2A member 2 (human)" EXACT [UniProtKB:P49641]
synonym: "mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (human)" BROAD [UniProtKB:P49641]
xref: Reactome:R-HSA-975824 "PR:P49641 located_in GO:0000139"
xref: Reactome:R-HSA-8847485 "PR:P49641 located_in GO:0030133"
xref: UniProtKB:P49641
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010106 ! alpha-mannosidase 2x
relationship: has_gene_template HGNC:6825 ! MAN2A2 (human)

[Term]
id: PR:000056584
name: alpha-mannosidase 2x O-glycosylated 2 (human)
def: "An alpha-mannosidase 2x (human) that has been O-glycosylated at the residue equivalent to Ser-45 of the amino acid sequence represented by UniProtKB:P49641-3, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P49641-3, Ser-45, MOD:00002~GNO:G43417UB." [GlyGen:P49641-3, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hMAN2A2/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49641-3, Ser-45, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P49641 ! alpha-mannosidase 2x (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000056583
name: alpha-mannosidase 2x O-glycosylated 1 (human)
def: "An alpha-mannosidase 2x (human) that has been O-glycosylated at the residue equivalent to Ser-107 of the amino acid sequence represented by UniProtKB:P49641-3, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P49641-3, Ser-107, MOD:00002~GNO:G43417UB." [GlyGen:P49641-3, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hMAN2A2/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49641-3, Ser-107, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P49641 ! alpha-mannosidase 2x (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8BRK9
name: alpha-mannosidase 2x (mouse)
def: "An alpha-mannosidase 2x that is encoded in the genome of mouse." [OMA:Q8BRK9, PRO:DNx]
comment: Category=organism-gene.
synonym: "Man2a2" RELATED Gene-based [UniProtKB:Q8BRK9]
synonym: "Mana2x" RELATED Gene-based [UniProtKB:Q8BRK9]
synonym: "mMAN2A2" EXACT PRO-short-label [PRO:DNx]
synonym: "Man IIx (mouse)" EXACT [UniProtKB:Q8BRK9]
synonym: "alpha-mannosidase IIx (mouse)" EXACT [UniProtKB:Q8BRK9]
synonym: "mannosidase alpha class 2A member 2 (mouse)" EXACT [UniProtKB:Q8BRK9]
synonym: "mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (mouse)" RELATED [UniProtKB:Q8BRK9]
xref: UniProtKB:Q8BRK9
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000010106 ! alpha-mannosidase 2x
relationship: has_gene_template MGI:2150656 ! Man2a2 (mouse)

[Term]
id: PR:Q8BRK9-2
name: alpha-mannosidase 2x isoform m2 (mouse)
def: "An alpha-mannosidase 2x (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BRK9-2." [PRO:DNx, UniProtKB:Q8BRK9]
comment: Category=organism-sequence.
synonym: "mMAN2A2/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8BRK9-2
is_a: PR:Q8BRK9 ! alpha-mannosidase 2x (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q8BRK9-1
name: alpha-mannosidase 2x isoform m1 (mouse)
def: "An alpha-mannosidase 2x (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BRK9-1." [PRO:DNx, UniProtKB:Q8BRK9]
comment: Category=organism-sequence.
synonym: "mMAN2A2/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8BRK9-1
is_a: PR:Q8BRK9 ! alpha-mannosidase 2x (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q54YF7
name: alpha-mannosidase B (Dictyostelium discoideum)
def: "An alpha-mannosidase 2x that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54YF7, PRO:DNx]
comment: Category=organism-gene.
synonym: "manB" RELATED Gene-based [UniProtKB:Q54YF7]
synonym: "DDB_G0278259" RELATED Gene-based [UniProtKB:Q54YF7]
synonym: "Dicty-MAN2A2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q54YF7
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000010106 ! alpha-mannosidase 2x
relationship: has_gene_template dictyBase:DDB_G0278259 ! manB (Dictyostelium discoideum)

[Term]
id: PR:P49641-1
name: alpha-mannosidase 2x isoform h1 (human)
def: "An alpha-mannosidase 2x (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49641-1." [PRO:DNx, UniProtKB:P49641]
comment: Category=organism-sequence.
synonym: "hMAN2A2/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-mannosidase 2x isoform Long (human)" EXACT [UniProtKB:P49641]
xref: UniProtKB:P49641-1
is_a: PR:P49641 ! alpha-mannosidase 2x (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49641-2
name: alpha-mannosidase 2x isoform h2 (human)
def: "An alpha-mannosidase 2x (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49641-2." [PRO:DNx, UniProtKB:P49641]
comment: Category=organism-sequence.
synonym: "hMAN2A2/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-mannosidase 2x isoform Short (human)" EXACT [UniProtKB:P49641]
xref: UniProtKB:P49641-2
is_a: PR:P49641 ! alpha-mannosidase 2x (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49641-3
name: alpha-mannosidase 2x isoform h3 (human)
def: "An alpha-mannosidase 2x (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49641-3." [PRO:DNx, UniProtKB:P49641]
comment: Category=organism-sequence.
synonym: "hMAN2A2/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49641-3
is_a: PR:P49641 ! alpha-mannosidase 2x (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens