[Term] id: PR:P48449-1 name: lanosterol synthase isoform h1 (human) def: "A lanosterol synthase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48449-1." [PRO:DNx, UniProtKB:P48449] comment: Category=organism-sequence. synonym: "hLSS/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P48449-1 is_a: PR:P48449 ! lanosterol synthase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P48449-3 name: lanosterol synthase isoform h3 (human) def: "A lanosterol synthase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48449-3." [PRO:DNx, UniProtKB:P48449] comment: Category=organism-sequence. synonym: "hLSS/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P48449-3 is_a: PR:P48449 ! lanosterol synthase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P48449-2 name: lanosterol synthase isoform h2 (human) def: "A lanosterol synthase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48449-2." [PRO:DNx, UniProtKB:P48449] comment: Category=organism-sequence. synonym: "hLSS/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P48449-2 is_a: PR:P48449 ! lanosterol synthase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q55D85 name: cycloartenol synthase (Dictyostelium discoideum) def: "A lanosterol synthase that is encoded in the genome of Dictyostelium discoideum." [OMA:Q55D85, PRO:DNx] comment: Category=organism-gene. synonym: "cas1" RELATED Gene-based [UniProtKB:Q55D85] synonym: "Dicty-LSS" EXACT PRO-short-label [PRO:DNx] synonym: "DDB_G0269226" RELATED Gene-based [UniProtKB:Q55D85] synonym: "oxidosqualene cyclase (Dictyostelium discoideum)" EXACT [UniProtKB:Q55D85] synonym: "2,3-epoxysqualene--cycloartenol cyclase (Dictyostelium discoideum)" EXACT [UniProtKB:Q55D85] xref: UniProtKB:Q55D85 intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum intersection_of: PR:000009969 ! lanosterol synthase relationship: has_gene_template dictyBase:DDB_G0269226 ! cas1 (Dictyostelium discoideum) [Term] id: PR:P33247 name: squalene--hopene cyclase (Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446) def: "A lanosterol synthase that is encoded in the genome of Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446." [OMA:P33247, PRO:DNx] comment: Category=organism-gene. Requested by=PubChem. synonym: "shc" RELATED Gene-based [UniProtKB:P33247] synonym: "Aaci_2443" RELATED Gene-based [UniProtKB:P33247] synonym: "LSS (ALIAD)" EXACT PRO-short-label [PRO:DNx] synonym: "squalene--hopanol cyclase (Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446)" EXACT [UniProtKB:P33247] xref: UniProtKB:P33247 intersection_of: only_in_taxon NCBITaxon:521098 ! Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 intersection_of: PR:000009969 ! lanosterol synthase relationship: has_gene_template NCBIGene:8425972 ! shc (Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446) [Term] id: PR:P38604 name: lanosterol synthase ERG7 (yeast) def: "A lanosterol synthase that is encoded in the genome of yeast." [OMA:P38604, PRO:DNx] comment: Category=organism-gene. synonym: "ERG7" RELATED Gene-based [UniProtKB:P38604] synonym: "yLSS" EXACT PRO-short-label [PRO:DNx] synonym: "YHR072W" RELATED Gene-based [UniProtKB:P38604] synonym: "OSC (yeast)" EXACT [UniProtKB:P38604] synonym: "ergosterol biosynthetic protein 7 (yeast)" EXACT [UniProtKB:P38604] synonym: "oxidosqualene--lanosterol cyclase ERG7 (yeast)" EXACT [UniProtKB:P38604] synonym: "2,3-epoxysqualene--lanosterol cyclase ERG7 (yeast)" EXACT [UniProtKB:P38604] xref: UniProtKB:P38604 intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C intersection_of: PR:000009969 ! lanosterol synthase relationship: has_gene_template SGD:S000001114 ! ERG7 (yeast) [Term] id: PR:P48450 name: lanosterol synthase (rat) def: "A lanosterol synthase that is encoded in the genome of rat." [PANTHER:PTHR11764:SF7, PRO:DNx] comment: Category=organism-gene. synonym: "Lss" RELATED Gene-based [UniProtKB:P48450] synonym: "Osc" RELATED Gene-based [UniProtKB:P48450] synonym: "rLSS" EXACT PRO-short-label [PRO:DNx] synonym: "OSC (rat)" EXACT [UniProtKB:P48450] synonym: "oxidosqualene--lanosterol cyclase (rat)" EXACT [UniProtKB:P48450] synonym: "2,3-epoxysqualene--lanosterol cyclase (rat)" EXACT [UniProtKB:P48450] xref: UniProtKB:P48450 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000009969 ! lanosterol synthase relationship: has_gene_template RGD:620955 ! Lss (rat) [Term] id: PR:P48450-1 name: lanosterol synthase isoform 1 (rat) def: "A lanosterol synthase isoform 1 that is encoded in the genome of rat." [PRO:DNx] comment: Category=organism-sequence. synonym: "rLSS/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P48450-1 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000041595 ! lanosterol synthase isoform 1 [Term] id: PR:000048264 name: lanosterol synthase, initiator methionine removed form (human) def: "A lanosterol synthase (human) that has had the initiator methionine removed. UniProtKB:P48449, 2-732." [PRO:DNx, Reactome:R-HSA-191371] comment: Category=organism-modification. synonym: "hLSS/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000072659" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P48449, 2-732" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-191371 "PR:000048264 located_in GO:0005789" intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:P48449 ! lanosterol synthase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P48449 name: lanosterol synthase (human) def: "A lanosterol synthase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P48449] comment: Category=organism-gene. synonym: "LSS" RELATED Gene-based [UniProtKB:P48449] synonym: "OSC" RELATED Gene-based [UniProtKB:P48449] synonym: "hLSS" EXACT PRO-short-label [PRO:DNx] synonym: "hOSC" EXACT [UniProtKB:P48449] synonym: "oxidosqualene--lanosterol cyclase (human)" EXACT [UniProtKB:P48449] synonym: "2,3-epoxysqualene--lanosterol cyclase (human)" EXACT [UniProtKB:P48449] xref: UniProtKB:P48449 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000009969 ! lanosterol synthase relationship: has_gene_template HGNC:6708 ! LSS (human) [Term] id: PR:000026640 name: lanosterol synthase, initiator methionine removed form def: "A lanosterol synthase that has had the initiator methionine removed." [PRO:DNx] comment: Category=modification. synonym: "LSS/InitMet-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000009969 ! lanosterol synthase intersection_of: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:Q8BLN5 name: lanosterol synthase (mouse) def: "A lanosterol synthase that is encoded in the genome of mouse." [OMA:Q8BLN5, PRO:DNx] comment: Category=organism-gene. synonym: "Lss" RELATED Gene-based [UniProtKB:Q8BLN5] synonym: "mLSS" EXACT PRO-short-label [PRO:DNx] synonym: "OSC (mouse)" EXACT [UniProtKB:Q8BLN5] synonym: "oxidosqualene--lanosterol cyclase (mouse)" EXACT [UniProtKB:Q8BLN5] synonym: "2,3-epoxysqualene--lanosterol cyclase (mouse)" EXACT [UniProtKB:Q8BLN5] xref: UniProtKB:Q8BLN5 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000009969 ! lanosterol synthase relationship: has_gene_template MGI:1336155 ! Lss (mouse) [Term] id: PR:000041595 name: lanosterol synthase isoform 1 def: "A lanosterol synthase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BLN5-1 or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=sequence. synonym: "LSS/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000009969 ! lanosterol synthase [Term] id: PR:000009969 name: lanosterol synthase def: "A protein that is a translation product of the human LSS gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "LSS" EXACT PRO-short-label [PRO:DNx] synonym: "OSC" RELATED Gene-based [] synonym: "oxidosqualene--lanosterol cyclase" EXACT [] synonym: "2,3-epoxysqualene--lanosterol cyclase" EXACT [] xref: IUPHARobj:2434 is_a: PR:000000001 ! protein [Term] id: PR:Q8BLN5-1 name: lanosterol synthase isoform 1 (mouse) def: "A lanosterol synthase isoform 1 that is encoded in the genome of mouse." [PRO:DNx] comment: Category=organism-sequence. synonym: "mLSS/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q8BLN5-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000041595 ! lanosterol synthase isoform 1 [Term] id: PR:Q10231 name: lanosterol synthase erg7 (Schizosaccharomyces pombe 972h-) def: "A lanosterol synthase that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q10231, PRO:DNx] comment: Category=organism-gene. synonym: "erg7" RELATED Gene-based [UniProtKB:Q10231] synonym: "SPAC4G9.21c" RELATED Gene-based [UniProtKB:Q10231] synonym: "SPAC13G7.01c" RELATED Gene-based [UniProtKB:Q10231] synonym: "Spom972h-LSS" EXACT PRO-short-label [PRO:DNx] synonym: "ergosterol biosynthetic protein 7 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q10231] synonym: "oxidosqualene--lanosterol cyclase erg7 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q10231] synonym: "2,3-epoxysqualene--lanosterol cyclase erg7 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q10231] xref: UniProtKB:Q10231 intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h- intersection_of: PR:000009969 ! lanosterol synthase relationship: has_gene_template PomBase:SPAC13G7.01c ! erg7 (Schizosaccharomyces pombe)