[Term]
id: PR:O35082-2
name: klotho isoform m2 (mouse)
def: "A klotho (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35082-2." [PRO:DNx, UniProtKB:O35082]
comment: Category=organism-sequence.
synonym: "mKL/iso:m2" EXACT PRO-short-label [PRO:DNx]
synonym: "klotho isoform Secreted (mouse)" EXACT [UniProtKB:O35082]
xref: UniProtKB:O35082-2
is_a: PR:O35082 ! klotho (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000009347
name: klotho
def: "A protein that is a translation product of the human KL gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "KL" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9UEF7
name: klotho (human)
def: "A klotho that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UEF7]
comment: Category=organism-gene.
synonym: "KL" RELATED Gene-based [UniProtKB:Q9UEF7]
synonym: "hKL" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9UEF7
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000009347 ! klotho
relationship: has_gene_template HGNC:6344 ! KL (human)

[Term]
id: PR:000020379
name: klotho proteolytic cleavage product
def: "A klotho that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "KL/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000009347 ! klotho

[Term]
id: PR:O35082-1
name: klotho isoform 1 (mouse)
def: "A klotho isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mKL/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "klotho isoform Membrane-bound (mouse)" EXACT [UniProtKB:O35082]
xref: UniProtKB:O35082-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038084 ! klotho isoform 1

[Term]
id: PR:000038084
name: klotho isoform 1
def: "A klotho that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35082-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "KL/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000009347 ! klotho

[Term]
id: PR:Q9Z2Y9-1
name: klotho isoform 1 (rat)
def: "A klotho isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rKL/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Z2Y9-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038084 ! klotho isoform 1

[Term]
id: PR:O35082
name: klotho (mouse)
def: "A klotho that is encoded in the genome of mouse." [OMA:O35082, PRO:DNx]
comment: Category=organism-gene.
synonym: "Kl" RELATED Gene-based [UniProtKB:O35082]
synonym: "mKL" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O35082
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000009347 ! klotho
relationship: has_gene_template MGI:1101771 ! Kl (mouse)

[Term]
id: PR:Q9Z2Y9
name: klotho (rat)
def: "A klotho that is encoded in the genome of rat." [OMA:Q9Z2Y9, PANTHER:PTHR10353:SF10, PRO:DNx]
comment: Category=organism-gene.
synonym: "Kl" RELATED Gene-based [UniProtKB:Q9Z2Y9]
synonym: "rKL" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Z2Y9
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000009347 ! klotho
relationship: has_gene_template RGD:620396 ! Kl (rat)

[Term]
id: PR:000058234
name: klotho O-glycosylated 1 (human)
def: "A klotho (human) that has been O-glycosylated at the residue equivalent to Ser-115 of the amino acid sequence represented by UniProtKB:Q9UEF7-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q9UEF7-1, Ser-115, MOD:00002~GNO:G43417UB." [GlyGen:Q9UEF7-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hKL/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9UEF7-1, Ser-115, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q9UEF7 ! klotho (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000030065
name: klotho phosphorylated 1 (mouse)
def: "A klotho phosphorylated 1 in mouse. UniProtKB:O35082, Tyr-499, MOD:00048." [PMID:17114649, PRO:HJD]
comment: Category=organism-modification. Note: Large-scale experiment.
synonym: "mKL/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O35082, Tyr-499, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000030064 ! klotho phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000030064
name: klotho phosphorylated 1
def: "A klotho that has been phosphorylated at the position equivalent to Tyr-499 of the amino acid sequence represented by UniProtKB:O35082. Example: UniProtKB:O35082, Tyr-499, MOD:00048." [PMID:17114649, PRO:HJD]
comment: Category=modification. Note: Large-scale experiment.
synonym: "KL/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000009347 ! klotho
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:Q9UEF7-1
name: klotho isoform h1 (human)
def: "A klotho (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UEF7-1." [PRO:DNx, UniProtKB:Q9UEF7]
comment: Category=organism-sequence.
synonym: "hKL/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "klotho isoform Membrane-bound (human)" EXACT [UniProtKB:Q9UEF7]
xref: UniProtKB:Q9UEF7-1
is_a: PR:Q9UEF7 ! klotho (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9UEF7-2
name: klotho isoform h2 (human)
def: "A klotho (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UEF7-2." [PRO:DNx, UniProtKB:Q9UEF7]
comment: Category=organism-sequence.
synonym: "hKL/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "klotho isoform Secreted (human)" EXACT [UniProtKB:Q9UEF7]
xref: UniProtKB:Q9UEF7-2
is_a: PR:Q9UEF7 ! klotho (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens