[Term]
id: PR:000050340
name: insulin hormone (human)
def: "An insulin hormone in human." [PRO:DAN]
comment: Category=organism-modification. Requested by=MAxO.
synonym: "insulin (human)" EXACT PRO-short-label [PRO:DAN]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000050339 ! insulin hormone

[Term]
id: PR:000048036
name: proinsulin (human)
def: "A proinsulin in human. UniProtKB:P01308, 25-110." [PRO:DAN, Reactome:R-HSA-264893]
comment: Category=organism-modification. Requested by=MAxO.
synonym: "hINS/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01308, 25-110" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "insulin, signal peptide removed form (human)" EXACT [PRO:DNx]
xref: Reactome:R-HSA-264893 "PR:000048036 located_in GO:0005788"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000020310 ! proinsulin

[Term]
id: PR:000009054
name: insulin gene translation product
def: "An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "INS" EXACT PRO-short-label [PRO:DNx]
synonym: "insulin" BROAD [PRO:DAN]
is_a: PR:000045358 ! insulin family protein

[Term]
id: PR:000050339
name: insulin hormone
def: "A proinsulin that has had the propeptide (C-peptide) excised, leaving the A chain (example: UniProtKB:P01308, 90-110) and B chain (example: UniProtKB:P01308, 25-54) connected by crosslinks." [PRO:DAN]
comment: Category=modification. Requested by=MAxO. Note: Though the final product resembles a complex, insulin is produced directly from a single chain without going through an intermediate where the A chain and B chain are free entities.
synonym: "insulin" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000020310 ! proinsulin

[Term]
id: PR:O73727
name: insulin (zebrafish)
def: "An insulin gene translation product that is encoded in the genome of zebrafish." [PRO:DNx]
comment: Category=organism-gene.
synonym: "ins" RELATED Gene-based [UniProtKB:O73727]
synonym: "z-INS" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O73727
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000009054 ! insulin gene translation product
relationship: has_gene_template ZFIN:ZDB-GENE-980526-110 ! ins (zebrafish)

[Term]
id: PR:000020310
name: proinsulin
def: "An insulin gene translation product that has had the signal peptide removed. Proinsulin consists of the insulin B and A chains linked by the C-peptide. Example: UniProtKB:P01308, 25-110." [PRO:DAN]
comment: Category=modification.
synonym: "INS/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "insulin, signal peptide removed form" EXACT [PRO:DNx]
intersection_of: PR:000009054 ! insulin gene translation product
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:P67970
name: insulin (chicken)
def: "An insulin gene translation product that is encoded in the genome of chicken." [OMA:P67970, PRO:DNx]
comment: Category=organism-gene.
synonym: "INS" RELATED Gene-based [UniProtKB:P67970]
synonym: "chick-INS" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P67970
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000009054 ! insulin gene translation product
relationship: has_gene_template CGNC:4941 ! INS (chicken)

[Term]
id: PR:P01308
name: insulin gene translation product (human)
def: "An insulin gene translation product that is encoded in the genome of human." [PRO:DAN, UniProtKB:P01308]
comment: Category=organism-gene.
synonym: "hINS" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01308
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000009054 ! insulin gene translation product
relationship: has_gene_template HGNC:6081 ! INS (human)