[Term]
id: PR:000008888
name: isocitrate dehydrogenase [NADP], mitochondrial
def: "A protein that is a translation product of the human IDH2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "IDH" BROAD [PRO:DNx]
synonym: "IDP" BROAD [PRO:DNx]
synonym: "IDH2" RELATED Gene-based []
synonym: "ICD-M" EXACT []
synonym: "IDH2nadp" EXACT PRO-short-label [PRO:DNx]
synonym: "NADP(+)-specific ICDH" BROAD [PRO:DNx]
synonym: "oxalosuccinate decarboxylase" BROAD [PRO:DNx]
xref: IUPHARobj:2885
is_a: PR:000000001 ! protein

[Term]
id: PR:P48735-2
name: isocitrate dehydrogenase [NADP], mitochondrial isoform h2 (human)
def: "An isocitrate dehydrogenase [NADP], mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48735-2." [PRO:DNx, UniProtKB:P48735]
comment: Category=organism-sequence.
synonym: "hIDH2nadp/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P48735-2
is_a: PR:P48735 ! isocitrate dehydrogenase [NADP], mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P48735-1
name: isocitrate dehydrogenase [NADP], mitochondrial isoform 1 (human)
def: "An isocitrate dehydrogenase [NADP], mitochondrial isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hIDH2nadp/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P48735-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039559 ! isocitrate dehydrogenase [NADP], mitochondrial isoform 1

[Term]
id: PR:P48735
name: isocitrate dehydrogenase [NADP], mitochondrial (human)
def: "An isocitrate dehydrogenase [NADP], mitochondrial that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "IDH2" RELATED Gene-based [UniProtKB:P48735]
synonym: "hIDH2nadp" EXACT PRO-short-label [PRO:DNx]
synonym: "IDH (human)" BROAD [UniProtKB:P48735]
synonym: "IDP (human)" BROAD [UniProtKB:P48735]
synonym: "ICD-M (human)" EXACT [UniProtKB:P48735]
synonym: "NADP(+)-specific ICDH (human)" BROAD [UniProtKB:P48735]
synonym: "oxalosuccinate decarboxylase (human)" BROAD [UniProtKB:P48735]
xref: UniProtKB:P48735
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008888 ! isocitrate dehydrogenase [NADP], mitochondrial
relationship: has_gene_template HGNC:5383 ! IDH2 (human)

[Term]
id: PR:000047942
name: isocitrate dehydrogenase [NADP], mitochondrial, transit peptide removed form (human)
def: "An isocitrate dehydrogenase [NADP], mitochondrial (human) that has had the transit peptide removed. UniProtKB:P48735, 40-452." [PRO:DNx, Reactome:R-HSA-450988]
comment: Category=organism-modification.
synonym: "PRO_0000014420" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hIDH2nadp/TransPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P48735, 40-452" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-450988 "PR:000047942 located_in GO:0005759"
intersection_of: PR:P48735 ! isocitrate dehydrogenase [NADP], mitochondrial (human)
intersection_of: lacks_part SO:0000725 ! transit_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens