[Term]
id: PR:Q7Z6Z7
name: E3 ubiquitin-protein ligase HUWE1 (human)
def: "An E3 ubiquitin-protein ligase HUWE1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q7Z6Z7]
comment: Category=organism-gene.
synonym: "HUWE1" RELATED Gene-based [UniProtKB:Q7Z6Z7]
synonym: "UREB1" RELATED Gene-based [UniProtKB:Q7Z6Z7]
synonym: "hHUWE1" EXACT PRO-short-label [PRO:DNx]
synonym: "HSPC272" RELATED Gene-based [UniProtKB:Q7Z6Z7]
synonym: "KIAA0312" RELATED Gene-based [UniProtKB:Q7Z6Z7]
synonym: "KIAA1578" RELATED Gene-based [UniProtKB:Q7Z6Z7]
synonym: "Mule (human)" EXACT [UniProtKB:Q7Z6Z7]
synonym: "LASU1 (human)" EXACT [UniProtKB:Q7Z6Z7]
synonym: "HectH9 (human)" EXACT [UniProtKB:Q7Z6Z7]
synonym: "URE-B1 (human)" EXACT [UniProtKB:Q7Z6Z7]
synonym: "ARF-BP1 (human)" EXACT [UniProtKB:Q7Z6Z7]
synonym: "ARF-binding protein 1 (human)" EXACT [UniProtKB:Q7Z6Z7]
synonym: "URE-binding protein 1 (human)" EXACT [UniProtKB:Q7Z6Z7]
synonym: "large structure of UREB1 (human)" EXACT [UniProtKB:Q7Z6Z7]
synonym: "Mcl-1 ubiquitin ligase E3 (human)" EXACT [UniProtKB:Q7Z6Z7]
synonym: "HECT-type E3 ubiquitin transferase HUWE1 (human)" EXACT [UniProtKB:Q7Z6Z7]
synonym: "HECT, UBA and WWE domain-containing protein 1 (human)" EXACT [UniProtKB:Q7Z6Z7]
synonym: "upstream regulatory element-binding protein 1 (human)" EXACT [UniProtKB:Q7Z6Z7]
synonym: "homologous to E6AP carboxyl terminus homologous protein 9 (human)" EXACT [UniProtKB:Q7Z6Z7]
xref: UniProtKB:Q7Z6Z7
xref: Reactome:R-HSA-975983 "PR:Q7Z6Z7 located_in GO:0005829"
xref: Reactome:R-HSA-6801467 "PR:Q7Z6Z7 located_in GO:1904813"
xref: Reactome:R-HSA-6801481 "PR:Q7Z6Z7 located_in GO:0034774"
xref: Reactome:R-HSA-6806466 "PR:Q7Z6Z7 located_in GO:0005576"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008845 ! E3 ubiquitin-protein ligase HUWE1
relationship: has_gene_template HGNC:30892 ! HUWE1 (human)

[Term]
id: PR:000008845
name: E3 ubiquitin-protein ligase HUWE1
def: "A protein that is a translation product of the human HUWE1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "Mule" EXACT []
synonym: "HUWE1" EXACT PRO-short-label [PRO:DNx]
synonym: "LASU1" EXACT []
synonym: "UREB1" RELATED Gene-based []
synonym: "HectH9" EXACT []
synonym: "URE-B1" EXACT []
synonym: "ARF-BP1" EXACT []
synonym: "HSPC272" RELATED Gene-based []
synonym: "KIAA0312" RELATED Gene-based []
synonym: "KIAA1578" RELATED Gene-based []
synonym: "E3Histone" EXACT []
synonym: "ARF-binding protein 1" EXACT []
synonym: "URE-binding protein 1" EXACT []
synonym: "large structure of UREB1" EXACT []
synonym: "Mcl-1 ubiquitin ligase E3" EXACT []
synonym: "HECT-type E3 ubiquitin transferase HUWE1" EXACT []
synonym: "HECT, UBA and WWE domain-containing protein 1" EXACT []
synonym: "upstream regulatory element-binding protein 1" EXACT []
synonym: "homologous to E6AP carboxyl terminus homologous protein 9" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q7Z6Z7-3
name: E3 ubiquitin-protein ligase HUWE1 isoform h3 (human)
def: "An E3 ubiquitin-protein ligase HUWE1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z6Z7-3." [PRO:DNx, UniProtKB:Q7Z6Z7]
comment: Category=organism-sequence.
synonym: "hHUWE1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q7Z6Z7-3
is_a: PR:Q7Z6Z7 ! E3 ubiquitin-protein ligase HUWE1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q7Z6Z7-2
name: E3 ubiquitin-protein ligase HUWE1 isoform h2 (human)
def: "An E3 ubiquitin-protein ligase HUWE1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z6Z7-2." [PRO:DNx, UniProtKB:Q7Z6Z7]
comment: Category=organism-sequence.
synonym: "hHUWE1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q7Z6Z7-2
is_a: PR:Q7Z6Z7 ! E3 ubiquitin-protein ligase HUWE1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q7Z6Z7-1
name: E3 ubiquitin-protein ligase HUWE1 isoform h1 (human)
def: "An E3 ubiquitin-protein ligase HUWE1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z6Z7-1." [PRO:DNx, UniProtKB:Q7Z6Z7]
comment: Category=organism-sequence.
synonym: "hHUWE1/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "E3 ubiquitin-protein ligase HUWE1 isoform LASU1 (human)" EXACT [UniProtKB:Q7Z6Z7]
synonym: "E3 ubiquitin-protein ligase HUWE1 isoform Large structure of UREB1 (human)" EXACT [UniProtKB:Q7Z6Z7]
xref: UniProtKB:Q7Z6Z7-1
is_a: PR:Q7Z6Z7 ! E3 ubiquitin-protein ligase HUWE1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens