[Term]
id: PR:000040230
name: hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
def: "A hydroxymethylglutaryl-CoA synthase, cytoplasmic that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q01581-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "HMGCS1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000008637 ! hydroxymethylglutaryl-CoA synthase, cytoplasmic

[Term]
id: PR:Q8JZK9-1
name: hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 (mouse)
def: "A hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mHMGCS1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8JZK9-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000040230 ! hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1

[Term]
id: PR:P17425-1
name: hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 (rat)
def: "A hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rHMGCS1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P17425-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000040230 ! hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1

[Term]
id: PR:Q01581-1
name: hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 (human)
def: "A hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hHMGCS1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q01581-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000040230 ! hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1

[Term]
id: PR:P17425
name: hydroxymethylglutaryl-CoA synthase, cytoplasmic (rat)
def: "A hydroxymethylglutaryl-CoA synthase, cytoplasmic that is encoded in the genome of rat." [OMA:P17425, PANTHER:PTHR11877:SF10, PRO:DNx]
comment: Category=organism-gene.
synonym: "Hmgcs" RELATED Gene-based [UniProtKB:P17425]
synonym: "Hmgcs1" RELATED Gene-based [UniProtKB:P17425]
synonym: "rHMGCS1" EXACT PRO-short-label [PRO:DNx]
synonym: "HMG-CoA synthase (rat)" RELATED [UniProtKB:P17425]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase (rat)" RELATED [UniProtKB:P17425]
xref: UniProtKB:P17425
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000008637 ! hydroxymethylglutaryl-CoA synthase, cytoplasmic
relationship: has_gene_template RGD:70970 ! Hmgcs1 (rat)

[Term]
id: PR:Q01581
name: hydroxymethylglutaryl-CoA synthase, cytoplasmic (human)
def: "A hydroxymethylglutaryl-CoA synthase, cytoplasmic that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q01581]
comment: Category=organism-gene.
synonym: "HMGCS" RELATED Gene-based [UniProtKB:Q01581]
synonym: "HMGCS1" RELATED Gene-based [UniProtKB:Q01581]
synonym: "hHMGCS1" EXACT PRO-short-label [PRO:DNx]
synonym: "HMG-CoA synthase (human)" BROAD [UniProtKB:Q01581]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase (human)" BROAD [UniProtKB:Q01581]
xref: Reactome:R-HSA-191329 "PR:Q01581 located_in GO:0005829"
xref: UniProtKB:Q01581
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008637 ! hydroxymethylglutaryl-CoA synthase, cytoplasmic
relationship: has_gene_template HGNC:5007 ! HMGCS1 (human)

[Term]
id: PR:Q8JZK9
name: hydroxymethylglutaryl-CoA synthase, cytoplasmic (mouse)
def: "A hydroxymethylglutaryl-CoA synthase, cytoplasmic that is encoded in the genome of mouse." [OMA:Q8JZK9, PRO:DNx]
comment: Category=organism-gene.
synonym: "Hmgcs1" RELATED Gene-based [UniProtKB:Q8JZK9]
synonym: "mHMGCS1" EXACT PRO-short-label [PRO:DNx]
synonym: "HMG-CoA synthase (mouse)" RELATED [UniProtKB:Q8JZK9]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase (mouse)" RELATED [UniProtKB:Q8JZK9]
xref: UniProtKB:Q8JZK9
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008637 ! hydroxymethylglutaryl-CoA synthase, cytoplasmic
relationship: has_gene_template MGI:107592 ! Hmgcs1 (mouse)

[Term]
id: PR:000008637
name: hydroxymethylglutaryl-CoA synthase, cytoplasmic
def: "A protein that is a translation product of the human HMGCS1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "HMGCS" RELATED Gene-based []
synonym: "HMGCS1" EXACT PRO-short-label [PRO:DNx]
synonym: "HMG-CoA synthase" BROAD [PRO:DNx]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase" BROAD [PRO:DNx]
xref: IUPHARobj:638
is_a: PR:000000001 ! protein

[Term]
id: PR:P23228
name: hydroxymethylglutaryl-CoA synthase, cytoplasmic (chicken)
def: "A hydroxymethylglutaryl-CoA synthase, cytoplasmic that is encoded in the genome of chicken." [OMA:P23228, PANTHER:PTHR11877:SF10, PRO:DNx]
comment: Category=organism-gene.
synonym: "HMGCS" RELATED Gene-based [UniProtKB:P23228]
synonym: "HMGCS1" RELATED Gene-based [UniProtKB:P23228]
synonym: "chick-HMGCS1" EXACT PRO-short-label [PRO:DNx]
synonym: "HMG-CoA synthase (chicken)" EXACT [UniProtKB:P23228]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase (chicken)" EXACT [UniProtKB:P23228]
xref: UniProtKB:P23228
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000008637 ! hydroxymethylglutaryl-CoA synthase, cytoplasmic
relationship: has_gene_template NCBIGene:396379 ! HMGCS1 (chicken)