[Term]
id: PR:000025736
name: hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1 acetylated 1 (human)
def: "A hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1 acetylated 1 in human. UniProtKB:P35914-1, Lys-48, MOD:00064." [PMID:19608861, PRO:CNA]
comment: Category=organism-modification.
synonym: "hHMGCL/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35914-1, Lys-48, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025735 ! hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:P35914
name: hydroxymethylglutaryl-CoA lyase, mitochondrial (human)
def: "A hydroxymethylglutaryl-CoA lyase, mitochondrial that is encoded in the genome of human." [PRO:DNx, UniProtKB:P35914]
comment: Category=organism-gene.
synonym: "HMGCL" RELATED Gene-based [UniProtKB:P35914]
synonym: "hHMGCL" EXACT PRO-short-label [PRO:DNx]
synonym: "HL (human)" BROAD [UniProtKB:P35914]
synonym: "HMG-CoA lyase (human)" EXACT [UniProtKB:P35914]
synonym: "3-hydroxy-3-methylglutarate-CoA lyase (human)" EXACT [UniProtKB:P35914]
xref: Reactome:R-HSA-9033112 "PR:P35914 located_in GO:0005829"
xref: Reactome:R-HSA-9033125 "PR:P35914 located_in GO:0005782"
xref: UniProtKB:P35914
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008635 ! hydroxymethylglutaryl-CoA lyase, mitochondrial
relationship: has_gene_template HGNC:5005 ! HMGCL (human)

[Term]
id: PR:000047879
name: hydroxymethylglutaryl-CoA lyase, mitochondrial, transit peptide removed form (human)
def: "A hydroxymethylglutaryl-CoA lyase, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P35914, 28-325." [PRO:DNx, Reactome:R-HSA-74172]
comment: Category=organism-modification.
synonym: "PRO_0000013478" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHMGCL/TransPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35914, 28-325" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-74172 "PR:000047879 located_in GO:0005759"
intersection_of: PR:P35914 ! hydroxymethylglutaryl-CoA lyase, mitochondrial (human)
intersection_of: lacks_part SO:0000725 ! transit_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P35914-2
name: hydroxymethylglutaryl-CoA lyase, mitochondrial isoform h2 (human)
def: "A hydroxymethylglutaryl-CoA lyase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35914-2." [PRO:DNx, UniProtKB:P35914]
comment: Category=organism-sequence.
synonym: "hHMGCL/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "hydroxymethylglutaryl-CoA lyase, mitochondrial isoform HMGCS2delta5,6 (human)" EXACT [UniProtKB:P35914]
xref: UniProtKB:P35914-2
is_a: PR:P35914 ! hydroxymethylglutaryl-CoA lyase, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P35914-3
name: hydroxymethylglutaryl-CoA lyase, mitochondrial isoform h3 (human)
def: "A hydroxymethylglutaryl-CoA lyase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35914-3." [PRO:DNx, UniProtKB:P35914]
comment: Category=organism-sequence.
synonym: "hHMGCL/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "hydroxymethylglutaryl-CoA lyase, mitochondrial isoform HMGCS2delta5,6,7 (human)" EXACT [UniProtKB:P35914]
xref: UniProtKB:P35914-3
is_a: PR:P35914 ! hydroxymethylglutaryl-CoA lyase, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P35914-1
name: hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1 (human)
def: "A hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1 that is encoded in the genome of human." [PMID:8440722, PRO:CNA]
comment: Category=organism-sequence.
synonym: "hHMGCL/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P35914-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025732 ! hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1

[Term]
id: PR:000008635
name: hydroxymethylglutaryl-CoA lyase, mitochondrial
def: "A protein that is a translation product of the human HMGCL gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "HL" RELATED []
synonym: "HMGCL" EXACT PRO-short-label [PRO:DNx]
synonym: "HMG-CoA lyase" EXACT []
synonym: "3-hydroxy-3-methylglutarate-CoA lyase" EXACT []
is_a: PR:000000001 ! protein