[Term]
id: PR:P19356-1
name: porphobilinogen deaminase isoform 1 (rat)
def: "A porphobilinogen deaminase isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rHMBS/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "porphobilinogen deaminase isoform Non-erythropoietic (rat)" EXACT [UniProtKB:P19356]
xref: UniProtKB:P19356-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038737 ! porphobilinogen deaminase isoform 1

[Term]
id: PR:P19356-2
name: porphobilinogen deaminase isoform r2 (rat)
def: "A porphobilinogen deaminase (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19356-2." [PRO:DNx, UniProtKB:P19356]
comment: Category=organism-sequence.
synonym: "rHMBS/iso:r2" EXACT PRO-short-label [PRO:DNx]
synonym: "porphobilinogen deaminase isoform Erythrocyte (rat)" EXACT [UniProtKB:P19356]
xref: UniProtKB:P19356-2
is_a: PR:P19356 ! porphobilinogen deaminase (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P19356
name: porphobilinogen deaminase (rat)
def: "A porphobilinogen deaminase that is encoded in the genome of rat." [OMA:P19356, PRO:DNx]
comment: Category=organism-gene.
synonym: "Hmbs" RELATED Gene-based [UniProtKB:P19356]
synonym: "rHMBS" EXACT PRO-short-label [PRO:DNx]
synonym: "HMBS (rat)" EXACT [UniProtKB:P19356]
synonym: "PBG-D (rat)" EXACT [UniProtKB:P19356]
synonym: "hydroxymethylbilane synthase (rat)" EXACT [UniProtKB:P19356]
synonym: "pre-uroporphyrinogen synthase (rat)" EXACT [UniProtKB:P19356]
xref: UniProtKB:P19356
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000008623 ! porphobilinogen deaminase
relationship: has_gene_template RGD:2801 ! Hmbs (rat)

[Term]
id: PR:Q09899
name: porphobilinogen deaminase (Schizosaccharomyces pombe 972h-)
def: "A porphobilinogen deaminase that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q09899, PANTHER:PTHR11557:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "hem3" RELATED Gene-based [UniProtKB:Q09899]
synonym: "SPAC806.01" RELATED Gene-based [UniProtKB:Q09899]
synonym: "SPAC24B11.13" RELATED Gene-based [UniProtKB:Q09899]
synonym: "Spom972h-HMBS" EXACT PRO-short-label [PRO:DNx]
synonym: "PBG (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09899]
synonym: "HMBS (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09899]
synonym: "hydroxymethylbilane synthase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09899]
synonym: "pre-uroporphyrinogen synthase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09899]
xref: UniProtKB:Q09899
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000008623 ! porphobilinogen deaminase
relationship: has_gene_template PomBase:SPAC24B11.13 ! hem3 (Schizosaccharomyces pombe)

[Term]
id: PR:P22907
name: porphobilinogen deaminase (mouse)
def: "A porphobilinogen deaminase that is encoded in the genome of mouse." [OMA:P22907, PRO:DNx]
comment: Category=organism-gene.
synonym: "Hmbs" RELATED Gene-based [UniProtKB:P22907]
synonym: "Uros1" RELATED Gene-based [UniProtKB:P22907]
synonym: "mHMBS" EXACT PRO-short-label [PRO:DNx]
synonym: "HMBS (mouse)" EXACT [UniProtKB:P22907]
synonym: "PBG-D (mouse)" EXACT [UniProtKB:P22907]
synonym: "hydroxymethylbilane synthase (mouse)" EXACT [UniProtKB:P22907]
synonym: "pre-uroporphyrinogen synthase (mouse)" EXACT [UniProtKB:P22907]
xref: UniProtKB:P22907
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008623 ! porphobilinogen deaminase
relationship: has_gene_template MGI:96112 ! Hmbs (mouse)

[Term]
id: PR:O94048
name: porphobilinogen deaminase (Candida albicans SC5314)
def: "A porphobilinogen deaminase that is encoded in the genome of Candida albicans SC5314." [OMA:O94048, PRO:DNx]
comment: Category=organism-gene. Note: Additional NCBIGenes (GeneIDs) listed in the UniProtKB entry have been reviewed and removed by PRO:DNx.
synonym: "HEM3" RELATED Gene-based [UniProtKB:O94048]
synonym: "Calb-HMBS" EXACT PRO-short-label [PRO:DNx]
synonym: "Ca38F10.02" RELATED Gene-based [UniProtKB:O94048]
synonym: "CaO19.1742" RELATED Gene-based [UniProtKB:O94048]
synonym: "CaO19.9309" RELATED Gene-based [UniProtKB:O94048]
synonym: "CAALFM_C210360CA" RELATED Gene-based [UniProtKB:O94048]
synonym: "PBG (Candida albicans SC5314)" EXACT [UniProtKB:O94048]
synonym: "HMBS (Candida albicans SC5314)" EXACT [UniProtKB:O94048]
synonym: "hydroxymethylbilane synthase (Candida albicans SC5314)" EXACT [UniProtKB:O94048]
synonym: "pre-uroporphyrinogen synthase (Candida albicans SC5314)" EXACT [UniProtKB:O94048]
xref: UniProtKB:O94048
intersection_of: only_in_taxon NCBITaxon:237561 ! Candida albicans SC5314
intersection_of: PR:000008623 ! porphobilinogen deaminase
relationship: has_gene_template NCBIGene:3643940 ! HEM3 (Candida albicans SC5314)

[Term]
id: PR:P08397
name: porphobilinogen deaminase (human)
def: "A porphobilinogen deaminase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08397]
comment: Category=organism-gene.
synonym: "UPS" RELATED Gene-based [UniProtKB:P08397]
synonym: "HMBS" RELATED Gene-based [UniProtKB:P08397]
synonym: "PBGD" RELATED Gene-based [UniProtKB:P08397]
synonym: "hHMBS" EXACT PRO-short-label [PRO:DNx]
synonym: "PBG-D (human)" EXACT [UniProtKB:P08397]
synonym: "hydroxymethylbilane synthase (human)" EXACT [UniProtKB:P08397]
synonym: "pre-uroporphyrinogen synthase (human)" EXACT [UniProtKB:P08397]
xref: Reactome:R-HSA-3004609 "PR:P08397 located_in GO:0005829"
xref: UniProtKB:P08397
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008623 ! porphobilinogen deaminase
relationship: has_gene_template HGNC:4982 ! HMBS (human)

[Term]
id: PR:P22907-2
name: porphobilinogen deaminase isoform m2 (mouse)
def: "A porphobilinogen deaminase (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22907-2." [PRO:DNx, UniProtKB:P22907]
comment: Category=organism-sequence.
synonym: "mHMBS/iso:m2" EXACT PRO-short-label [PRO:DNx]
synonym: "porphobilinogen deaminase isoform Erythrocyte (mouse)" EXACT [UniProtKB:P22907]
xref: UniProtKB:P22907-2
is_a: PR:P22907 ! porphobilinogen deaminase (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P22907-1
name: porphobilinogen deaminase isoform 1 (mouse)
def: "A porphobilinogen deaminase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mHMBS/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "porphobilinogen deaminase isoform Non-erythropoietic (mouse)" EXACT [UniProtKB:P22907]
xref: UniProtKB:P22907-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038737 ! porphobilinogen deaminase isoform 1

[Term]
id: PR:P28789
name: porphobilinogen deaminase (yeast)
def: "A porphobilinogen deaminase that is encoded in the genome of yeast." [OMA:P28789, PANTHER:PTHR11557:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "HEM3" RELATED Gene-based [UniProtKB:P28789]
synonym: "D1057" RELATED Gene-based [UniProtKB:P28789]
synonym: "yHMBS" EXACT PRO-short-label [PRO:DNx]
synonym: "YDL205C" RELATED Gene-based [UniProtKB:P28789]
synonym: "PBG (yeast)" EXACT [UniProtKB:P28789]
synonym: "HMBS (yeast)" EXACT [UniProtKB:P28789]
synonym: "hydroxymethylbilane synthase (yeast)" EXACT [UniProtKB:P28789]
synonym: "pre-uroporphyrinogen synthase (yeast)" EXACT [UniProtKB:P28789]
xref: UniProtKB:P28789
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000008623 ! porphobilinogen deaminase
relationship: has_gene_template SGD:S000002364 ! HEM3 (yeast)

[Term]
id: PR:000038737
name: porphobilinogen deaminase isoform 1
def: "A porphobilinogen deaminase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08397-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "HMBS/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000008623 ! porphobilinogen deaminase

[Term]
id: PR:P08397-4
name: porphobilinogen deaminase isoform h4 (human)
def: "A porphobilinogen deaminase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08397-4." [PRO:DNx, UniProtKB:P08397]
comment: Category=organism-sequence.
synonym: "hHMBS/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08397-4
is_a: PR:P08397 ! porphobilinogen deaminase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08397-3
name: porphobilinogen deaminase isoform h3 (human)
def: "A porphobilinogen deaminase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08397-3." [PRO:DNx, UniProtKB:P08397]
comment: Category=organism-sequence.
synonym: "hHMBS/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08397-3
is_a: PR:P08397 ! porphobilinogen deaminase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P06983
name: porphobilinogen deaminase (Escherichia coli K-12)
def: "A porphobilinogen deaminase that is encoded in the genome of Escherichia coli K-12." [OMA:P06983, PRO:DNx]
comment: Category=organism-gene.
synonym: "hemC" RELATED Gene-based [UniProtKB:P06983]
synonym: "popE" RELATED Gene-based [UniProtKB:P06983]
synonym: "b3805" RELATED Gene-based [UniProtKB:P06983]
synonym: "JW5932" RELATED Gene-based [UniProtKB:P06983]
synonym: "Ec-HMBS" EXACT PRO-short-label [PRO:DNx]
synonym: "PBG (Escherichia coli K-12)" EXACT [UniProtKB:P06983]
synonym: "HMBS (Escherichia coli K-12)" EXACT [UniProtKB:P06983]
synonym: "hydroxymethylbilane synthase (Escherichia coli K-12)" EXACT [UniProtKB:P06983]
synonym: "pre-uroporphyrinogen synthase (Escherichia coli K-12)" EXACT [UniProtKB:P06983]
xref: UniProtKB:P06983
intersection_of: only_in_taxon NCBITaxon:83333 ! Escherichia coli K-12
intersection_of: PR:000008623 ! porphobilinogen deaminase
relationship: has_gene_template NCBIGene:947759 ! hemC (Escherichia coli K-12)

[Term]
id: PR:P08397-1
name: porphobilinogen deaminase isoform 1 (human)
def: "A porphobilinogen deaminase isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hHMBS/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "porphobilinogen deaminase isoform Non-erythropoietic (human)" EXACT [UniProtKB:P08397]
xref: UniProtKB:P08397-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038737 ! porphobilinogen deaminase isoform 1

[Term]
id: PR:O34090
name: porphobilinogen deaminase (Staphylococcus aureus subsp. aureus NCTC 8325)
def: "A porphobilinogen deaminase that is encoded in the genome of Staphylococcus aureus subsp. aureus NCTC 8325." [OMA:O34090, PRO:DNx]
comment: Category=organism-gene.
synonym: "hemC" RELATED Gene-based [UniProtKB:O34090]
synonym: "HMBS (STAA8)" EXACT PRO-short-label [PRO:DNx]
synonym: "SAOUHSC_01774" RELATED Gene-based [UniProtKB:O34090]
synonym: "PBG (Staphylococcus aureus subsp. aureus NCTC 8325)" RELATED [PRO:DAN, UniProtKB:O34090]
synonym: "HMBS (Staphylococcus aureus subsp. aureus NCTC 8325)" EXACT [UniProtKB:O34090]
synonym: "hydroxymethylbilane synthase (Staphylococcus aureus subsp. aureus NCTC 8325)" EXACT [UniProtKB:O34090]
synonym: "pre-uroporphyrinogen synthase (Staphylococcus aureus subsp. aureus NCTC 8325)" EXACT [UniProtKB:O34090]
xref: UniProtKB:O34090
intersection_of: only_in_taxon NCBITaxon:93061 ! Staphylococcus aureus subsp. aureus NCTC 8325
intersection_of: PR:000008623 ! porphobilinogen deaminase
relationship: has_gene_template EnsemblBacteria:SAOUHSC_01774 ! hemC (Staphylococcus aureus subsp. aureus NCTC 8325)

[Term]
id: PR:Q43316
name: porphobilinogen deaminase, chloroplastic (Arabidopsis thaliana)
def: "A porphobilinogen deaminase that is encoded in the genome of Arabidopsis thaliana." [OMA:Q43316, PANTHER:PTHR11557:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "HEMC" RELATED Gene-based [UniProtKB:Q43316]
synonym: "RUG1" RELATED Gene-based [UniProtKB:Q43316]
synonym: "At-HMBS" EXACT PRO-short-label [PRO:DNx]
synonym: "F8L15_10" RELATED Gene-based [UniProtKB:Q43316]
synonym: "At5g08280" RELATED Gene-based [UniProtKB:Q43316]
synonym: "PBG (Arabidopsis thaliana)" EXACT [UniProtKB:Q43316]
synonym: "HMBS (Arabidopsis thaliana)" EXACT [UniProtKB:Q43316]
synonym: "protein RUGOSA1 (Arabidopsis thaliana)" EXACT [UniProtKB:Q43316]
synonym: "hydroxymethylbilane synthase (Arabidopsis thaliana)" EXACT [UniProtKB:Q43316]
synonym: "pre-uroporphyrinogen synthase (Arabidopsis thaliana)" EXACT [UniProtKB:Q43316]
xref: UniProtKB:Q43316
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000008623 ! porphobilinogen deaminase
relationship: has_gene_template Araport:AT5G08280 ! HEMC (Arabidopsis thaliana)

[Term]
id: PR:000008623
name: porphobilinogen deaminase
def: "A protein that is a translation product of the human HMBS gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "UPS" RELATED Gene-based []
synonym: "HMBS" EXACT PRO-short-label [PRO:DNx]
synonym: "PBGD" RELATED Gene-based []
synonym: "PBG-D" EXACT []
synonym: "Uros1" RELATED Gene-based []
synonym: "hydroxymethylbilane synthase" EXACT []
synonym: "pre-uroporphyrinogen synthase" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q54P93
name: porphobilinogen deaminase (Dictyostelium discoideum)
def: "A porphobilinogen deaminase that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54P93, PANTHER:PTHR11557:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "hemC" RELATED Gene-based [UniProtKB:Q54P93]
synonym: "Dicty-HMBS" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0284697" RELATED Gene-based [UniProtKB:Q54P93]
synonym: "HMBS (Dictyostelium discoideum)" EXACT [UniProtKB:Q54P93]
synonym: "heme biosynthesis protein C (Dictyostelium discoideum)" EXACT [UniProtKB:Q54P93]
synonym: "hydroxymethylbilane synthase (Dictyostelium discoideum)" EXACT [UniProtKB:Q54P93]
xref: UniProtKB:Q54P93
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000008623 ! porphobilinogen deaminase
relationship: has_gene_template dictyBase:DDB_G0284697 ! hemC (Dictyostelium discoideum)

[Term]
id: PR:P08397-2
name: porphobilinogen deaminase isoform h2 (human)
def: "A porphobilinogen deaminase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08397-2." [PRO:DNx, UniProtKB:P08397]
comment: Category=organism-sequence.
synonym: "hHMBS/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "porphobilinogen deaminase isoform Erythrocyte (human)" EXACT [UniProtKB:P08397]
xref: UniProtKB:P08397-2
is_a: PR:P08397 ! porphobilinogen deaminase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens