[Term]
id: PR:P62806-1
name: histone H4 isoform 1 (mouse)
def: "A histone H4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mH4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P62806-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000040025 ! histone H4 isoform 1

[Term]
id: PR:P62801-1
name: histone H4 isoform 1 (chicken)
def: "A histone H4 isoform 1 that is encoded in the genome of chicken." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "chick-H4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P62801-1
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000040025 ! histone H4 isoform 1

[Term]
id: PR:P62804-1
name: histone H4 isoform rHistone H4 (rat)
def: "A histone H4 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P62804-1." [PRO:DNx, UniProtKB:P62804]
comment: Category=organism-sequence.
synonym: "rH4/iso:rHistone H4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P62804-1
is_a: PR:P62804 ! histone H4 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P62804-2
name: histone H4 isoform OGP precursor (rat)
def: "A histone H4 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P62804-2." [PRO:DNx, UniProtKB:P62804]
comment: Category=organism-sequence.
synonym: "rH4/iso:OGP precursor" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P62804-2
is_a: PR:P62804 ! histone H4 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P02309
name: histone H4 (yeast)
def: "A histone H4 that is encoded in the genome of yeast." [OMA:P02309, PRO:DNx]
comment: Category=organism-gene. Note: The HHF1 and HHF2 genes encode identical proteins.
synonym: "yH4" EXACT PRO-short-label [PRO:DNx]
synonym: "HHF1" RELATED Gene-based [UniProtKB:P02309]
synonym: "HHF2" RELATED Gene-based [UniProtKB:P02309]
synonym: "N2752" RELATED Gene-based [UniProtKB:P02309]
synonym: "YBR009C" RELATED Gene-based [UniProtKB:P02309]
synonym: "YBR0122" RELATED Gene-based [UniProtKB:P02309]
synonym: "YNL030W" RELATED Gene-based [UniProtKB:P02309]
xref: UniProtKB:P02309
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000008603 ! histone H4
relationship: has_gene_template SGD:S000000213 ! HHF1 (yeast)
relationship: has_gene_template SGD:S000004975 ! HHF2 (yeast)

[Term]
id: PR:000020152
name: histone H4, initiator methionine removed form
def: "A histone H4 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "H4/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000008603 ! histone H4
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P62805-1
name: histone H4 isoform 1 (human)
def: "A histone H4 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hH4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P62805-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000040025 ! histone H4 isoform 1

[Term]
id: PR:P09322
name: histone H4 (Schizosaccharomyces pombe 972h-)
def: "A histone H4 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:P09322, PRO:DNx]
comment: Category=organism-gene. Note: The hhf1, hhf2, and hhf3 genes encode identical proteins.
synonym: "h4.1" RELATED Gene-based [UniProtKB:P09322]
synonym: "h4.2" RELATED Gene-based [UniProtKB:P09322]
synonym: "h4.3" RELATED Gene-based [UniProtKB:P09322]
synonym: "hhf1" RELATED Gene-based [UniProtKB:P09322]
synonym: "hhf2" RELATED Gene-based [UniProtKB:P09322]
synonym: "hhf3" RELATED Gene-based [UniProtKB:P09322]
synonym: "pi061" RELATED Gene-based [UniProtKB:P09322]
synonym: "SPBC1105.12" RELATED Gene-based [UniProtKB:P09322]
synonym: "SPBC8D2.03c" RELATED Gene-based [UniProtKB:P09322]
synonym: "Spom972h-H4" EXACT PRO-short-label [PRO:DAN]
synonym: "SPAC1834.03c" RELATED Gene-based [UniProtKB:P09322]
synonym: "Spom972h-hhf[1/2/3]" EXACT [PRO:DAN]
xref: UniProtKB:P09322
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000008603 ! histone H4
relationship: has_gene_template PomBase:SPAC1834.03c ! hhf1 (Schizosaccharomyces pombe)
relationship: has_gene_template PomBase:SPBC1105.12 ! hhf3 (Schizosaccharomyces pombe)
relationship: has_gene_template PomBase:SPBC8D2.03c ! hhf2 (Schizosaccharomyces pombe)

[Term]
id: PR:P62784-1
name: histone H4 isoform 1 (worm)
def: "A histone H4 isoform 1 that is encoded in the genome of worm." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "H4/iso:1 (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P62784-1
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000040025 ! histone H4 isoform 1

[Term]
id: PR:000050536
name: histone H4, hhf3 gene translation product, initiator methionine removed dimethylated 1 (Schizosaccharomyces pombe)
def: "A histone H4, hhf3 gene translation product (Schizosaccharomyces pombe) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P09322. UniProtKB:P09322, 2-103, Lys-21, MOD:00084." [PMID:22150589, PRO:DAN, PomBase:VW]
comment: Category=organism-modification. Requested by=PomBase. Note: Residue numbering for histones typically account for intiiator methionine removal. Hence, Lys-21 of the full sequence as presented in UniProtKB:P09322 is called K20 in the literature.
synonym: "Spom-hhf3/InitMet-/Me2:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000158357, Lys-21, MOD:00084" BROAD PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P09322, 2-103, Lys-21, MOD:00084" BROAD PRO-proteoform-std [PRO:DAN]
synonym: "histone H4 K20me2 (Schizosaccharomyces pombe)" BROAD [PRO:DAN]
synonym: "histone H4 hhf3 K20me2 (Schizosaccharomyces pombe)" EXACT [PRO:DAN]
is_a: PR:000050528 ! histone H4, hhf3 gene translation product (Schizosaccharomyces pombe)
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P62805
name: histone H4 (human)
def: "A histone H4 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-gene. Note: The HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, and HIST4H4 genes encode identical proteins.
synonym: "hH4" EXACT PRO-short-label [PRO:DNx]
synonym: "H4/A" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/B" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/C" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/D" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/E" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/G" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/H" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/I" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/J" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/K" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/M" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/N" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/O" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4C1" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C2" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C3" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C4" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C5" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C6" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C8" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C9" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4F2" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FA" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FB" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FC" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FD" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FE" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FG" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FH" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FI" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FJ" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FK" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FM" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FN" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FO" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4-16" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C11" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C12" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C13" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C14" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C15" RELATED Gene-based [UniProtKB:P62805]
synonym: "HIST2H4" RELATED Gene-based [UniProtKB:P62805]
synonym: "HIST4H4" RELATED Gene-based [UniProtKB:P62805]
synonym: "HIST1H4A" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4B" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4C" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4D" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4E" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4F" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4H" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4I" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4J" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4K" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4L" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST2H4A" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST2H4B" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
xref: UniProtKB:P62805
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008603 ! histone H4
relationship: has_gene_template HGNC:20510 ! HIST4H4 (human)
relationship: has_gene_template HGNC:29607 ! HIST2H4B (human)
relationship: has_gene_template HGNC:4781 ! HIST1H4A (human)
relationship: has_gene_template HGNC:4782 ! HIST1H4D (human)
relationship: has_gene_template HGNC:4783 ! HIST1H4F (human)
relationship: has_gene_template HGNC:4784 ! HIST1H4K (human)
relationship: has_gene_template HGNC:4785 ! HIST1H4J (human)
relationship: has_gene_template HGNC:4787 ! HIST1H4C (human)
relationship: has_gene_template HGNC:4788 ! HIST1H4H (human)
relationship: has_gene_template HGNC:4789 ! HIST1H4B (human)
relationship: has_gene_template HGNC:4790 ! HIST1H4E (human)
relationship: has_gene_template HGNC:4791 ! HIST1H4L (human)
relationship: has_gene_template HGNC:4793 ! HIST1H4I (human)
relationship: has_gene_template HGNC:4794 ! HIST2H4A (human)

[Term]
id: PR:P62804
name: histone H4 (rat)
def: "A histone H4 that is encoded in the genome of rat." [OMA:P62804, PRO:DAN]
comment: Category=organism-gene. Note: The Hist1h4b, Hist1h4m, and Hist4h4 genes encode identical proteins.
synonym: "rH4" EXACT PRO-short-label [PRO:DNx]
synonym: "H4c2" RELATED Gene-based [UniProtKB:P62804]
synonym: "H4ft" RELATED Gene-based [UniProtKB:P62804]
synonym: "H4f16" RELATED Gene-based [UniProtKB:P62804]
synonym: "Hist4" RELATED Gene-based [UniProtKB:P62804]
synonym: "Hist4h4" RELATED Gene-based [UniProtKB:P62804]
synonym: "Hist1h4b" RELATED Gene-based [UniProtKB:P62804]
synonym: "Hist1h4m" RELATED Gene-based [UniProtKB:P62804]
xref: UniProtKB:P62804
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000008603 ! histone H4
relationship: has_gene_template RGD:1306905 ! Hist1h4m (rat)
relationship: has_gene_template RGD:1596791 ! Hist4h4 (rat)
relationship: has_gene_template RGD:620814 ! Hist1h4b (rat)

[Term]
id: PR:P62806
name: histone H4 (mouse)
def: "A histone H4 that is encoded in the genome of mouse." [OMA:P62806, PRO:DNx]
comment: Category=organism-gene. Note: The Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4, and Hist4h4 genes encode identical proteins.
synonym: "mH4" EXACT PRO-short-label [PRO:DNx]
synonym: "H4c1" RELATED Gene-based [UniProtKB:P62806]
synonym: "H4c2" RELATED Gene-based [UniProtKB:P62806]
synonym: "H4c3" RELATED Gene-based [UniProtKB:P62806]
synonym: "H4c4" RELATED Gene-based [UniProtKB:P62806]
synonym: "H4c6" RELATED Gene-based [UniProtKB:P62806]
synonym: "H4c8" RELATED Gene-based [UniProtKB:P62806]
synonym: "H4c9" RELATED Gene-based [UniProtKB:P62806]
synonym: "H4-12" RELATED Gene-based [UniProtKB:P62806]
synonym: "H4-53" RELATED Gene-based [UniProtKB:P62806]
synonym: "H4c11" RELATED Gene-based [UniProtKB:P62806]
synonym: "H4c12" RELATED Gene-based [UniProtKB:P62806]
synonym: "H4c14" RELATED Gene-based [UniProtKB:P62806]
synonym: "H4f16" RELATED Gene-based [UniProtKB:P62806]
synonym: "Hist2h4" RELATED Gene-based [UniProtKB:P62806]
synonym: "Hist4h4" RELATED Gene-based [UniProtKB:P62806]
synonym: "Hist1h4a" RELATED Gene-based [UniProtKB:P62806]
synonym: "Hist1h4b" RELATED Gene-based [UniProtKB:P62806]
synonym: "Hist1h4c" RELATED Gene-based [UniProtKB:P62806]
synonym: "Hist1h4d" RELATED Gene-based [UniProtKB:P62806]
synonym: "Hist1h4f" RELATED Gene-based [UniProtKB:P62806]
synonym: "Hist1h4h" RELATED Gene-based [UniProtKB:P62806]
synonym: "Hist1h4i" RELATED Gene-based [UniProtKB:P62806]
synonym: "Hist1h4j" RELATED Gene-based [UniProtKB:P62806]
synonym: "Hist1h4k" RELATED Gene-based [UniProtKB:P62806]
synonym: "Hist1h4m" RELATED Gene-based [UniProtKB:P62806]
synonym: "Hist2h4a" RELATED Gene-based [UniProtKB:P62806]
xref: UniProtKB:P62806
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008603 ! histone H4
relationship: has_gene_template MGI:2140113 ! Hist2h4 (mouse)
relationship: has_gene_template MGI:2448419 ! Hist1h4a (mouse)
relationship: has_gene_template MGI:2448420 ! Hist1h4b (mouse)
relationship: has_gene_template MGI:2448421 ! Hist1h4c (mouse)
relationship: has_gene_template MGI:2448423 ! Hist1h4d (mouse)
relationship: has_gene_template MGI:2448425 ! Hist1h4f (mouse)
relationship: has_gene_template MGI:2448427 ! Hist1h4h (mouse)
relationship: has_gene_template MGI:2448432 ! Hist1h4i (mouse)
relationship: has_gene_template MGI:2448436 ! Hist1h4j (mouse)
relationship: has_gene_template MGI:2448439 ! Hist1h4k (mouse)
relationship: has_gene_template MGI:2448441 ! Hist1h4m (mouse)
relationship: has_gene_template MGI:2448443 ! Hist4h4 (mouse)

[Term]
id: PR:P62801
name: histone H4 (chicken)
def: "A histone H4 that is encoded in the genome of chicken." [OMA:P62801, PRO:DAN]
comment: Category=organism-gene. Note: The HIST1H46, HIST1H46L2, HIST1H46L6, HIST1H4B, HIST1H4D, HIST1H4I, and HIST2H4B genes encode identical proteins.
synonym: "H4-I" RELATED Gene-based [UniProtKB:P62801]
synonym: "H4-V" RELATED Gene-based [UniProtKB:P62801]
synonym: "H4-II" RELATED Gene-based [UniProtKB:P62801]
synonym: "H4-IV" RELATED Gene-based [UniProtKB:P62801]
synonym: "H4-VI" RELATED Gene-based [UniProtKB:P62801]
synonym: "H4-III" RELATED Gene-based [UniProtKB:P62801]
synonym: "H4-VII" RELATED Gene-based [UniProtKB:P62801]
synonym: "chick-H4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P62801
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000008603 ! histone H4
relationship: has_gene_template CGNC:50627 ! HIST1H46 (chicken)
relationship: has_gene_template CGNC:50630 ! HIST2H4B (chicken)
relationship: has_gene_template CGNC:532154 ! HIST1H4D (chicken)
relationship: has_gene_template CGNC:55704 ! HIST1H4B (chicken)
relationship: has_gene_template CGNC:55804 ! HIST1H46L6 (chicken)
relationship: has_gene_template CGNC:64760 ! HIST1H4I (chicken)
relationship: has_gene_template CGNC:65021 ! HIST1H46L2 (chicken)

[Term]
id: PR:000050537
name: histone H4, hhf3 gene translation product, initiator methionine removed trimethylated 1 (Schizosaccharomyces pombe)
def: "A histone H4, hhf3 gene translation product (Schizosaccharomyces pombe) that has had the initiator methionine removed and that has been trimethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P09322. UniProtKB:P09322, 2-103, Lys-21, MOD:00083." [PMID:22150589, PRO:DAN, PomBase:VW]
comment: Category=organism-modification. Requested by=PomBase. Note: Residue numbering for histones typically account for intiiator methionine removal. Hence, Lys-21 of the full sequence as presented in UniProtKB:P09322 is called K20 in the literature.
synonym: "Spom-hhf3/InitMet-/Me3:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000158357, Lys-21, MOD:00083" BROAD PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P09322, 2-103, Lys-21, MOD:00083" BROAD PRO-proteoform-std [PRO:DAN]
synonym: "histone H4 K20me3 (Schizosaccharomyces pombe)" BROAD [PRO:DAN]
synonym: "histone H4 hhf3 K20me3 (Schizosaccharomyces pombe)" EXACT [PRO:DAN]
is_a: PR:000050528 ! histone H4, hhf3 gene translation product (Schizosaccharomyces pombe)
relationship: has_part MOD:00083 ! N6,N6,N6-trimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000050528
name: histone H4, hhf3 gene translation product (Schizosaccharomyces pombe)
def: "A histone H4 (Schizosaccharomyces pombe) that is a translation product of the hhf3 gene in Schizosaccharomyces pombe." [PRO:DAN]
comment: Category=organism-gene. Note: The proteins encoded by hhf1 (PR:000050526), hhf2 (PR:000050527), and hhf3 (this class) are identical.
synonym: "h4.3" RELATED Gene-based [UniProtKB:P09322]
synonym: "hhf3" RELATED Gene-based [UniProtKB:P09322]
synonym: "Spom-hhf3" EXACT PRO-short-label [PRO:DAN]
synonym: "SPAC1834.03c" RELATED Gene-based [UniProtKB:P09322]
intersection_of: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
intersection_of: PR:000050525 ! histone H4 (Schizosaccharomyces pombe)
intersection_of: has_gene_template PomBase:SPBC1105.12 ! hhf3 (Schizosaccharomyces pombe)

[Term]
id: PR:000050529
name: histone H4, hhf1 gene translation product, initiator methionine removed monomethylated 1 (Schizosaccharomyces pombe)
def: "A histone H4, hhf1 gene translation product (Schizosaccharomyces pombe) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P09322. UniProtKB:P09322, 2-103, Lys-21, MOD:00085." [PMID:22150589, PRO:DAN, PomBase:VW]
comment: Category=organism-modification. Requested by=PomBase. Note: Residue numbering for histones typically account for intiiator methionine removal. Hence, Lys-21 of the full sequence as presented in UniProtKB:P09322 is called K20 in the literature.
synonym: "Spom-hhf1/InitMet-/Me1:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000158357, Lys-21, MOD:00085" BROAD PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P09322, 2-103, Lys-21, MOD:00085" BROAD PRO-proteoform-std [PRO:DAN]
synonym: "histone H4 K20me1 (Schizosaccharomyces pombe)" BROAD [PRO:DAN]
synonym: "histone H4 hhf1 K20me1 (Schizosaccharomyces pombe)" EXACT [PRO:DAN]
is_a: PR:000050526 ! histone H4, hhf1 gene translation product (Schizosaccharomyces pombe)
relationship: has_part MOD:00085 ! N6-methyl-L-lysine
relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000050526
name: histone H4, hhf1 gene translation product (Schizosaccharomyces pombe)
def: "A histone H4 (Schizosaccharomyces pombe) that is a translation product of the hhf1 gene in Schizosaccharomyces pombe." [PRO:DAN]
comment: Category=organism-gene. Note: The proteins encoded by hhf1 (this class), hhf2 (PR:000050527), and hhf3 (PR:000050528) are identical.
synonym: "h4.1" RELATED Gene-based [UniProtKB:P09322]
synonym: "hhf1" RELATED Gene-based [UniProtKB:P09322]
synonym: "Spom-hhf1" EXACT PRO-short-label [PRO:DAN]
synonym: "SPAC1834.03c" RELATED Gene-based [UniProtKB:P09322]
intersection_of: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
intersection_of: PR:000050525 ! histone H4 (Schizosaccharomyces pombe)
intersection_of: has_gene_template PomBase:SPAC1834.03c ! hhf1 (Schizosaccharomyces pombe)

[Term]
id: PR:000045330
name: histone H4, initiator methionine removed acetylated 5 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-9 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-9, MOD:00064." [HIstome_var_Hs:Histone_H4, PMID:10958685, PMID:16387653, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K8ac" BROAD [HIstome_ptm_Hs:H4K8ac]
synonym: "hH4/InitMet-/Ac:5" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-9, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-9, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568758 "PR:000045330 located_in GO:0005654"
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:Q76NW2
name: histone H4 (Dictyostelium discoideum)
def: "A histone H4 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q76NW2, PRO:DNx]
comment: Category=organism-gene. Note: The H4a and H4b genes encode identical proteins.
synonym: "H4a" RELATED Gene-based [UniProtKB:Q76NW2]
synonym: "H4b" RELATED Gene-based [UniProtKB:Q76NW2]
synonym: "Dicty-H4" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0276863" RELATED Gene-based [UniProtKB:Q76NW2]
synonym: "DDB_G0277183" RELATED Gene-based [UniProtKB:Q76NW2]
xref: UniProtKB:Q76NW2
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000008603 ! histone H4
relationship: has_gene_template dictyBase:DDB_G0276863 ! H4b (Dictyostelium discoideum)
relationship: has_gene_template dictyBase:DDB_G0277183 ! H4a (Dictyostelium discoideum)

[Term]
id: PR:000050525
name: histone H4 (Schizosaccharomyces pombe)
def: "A histone H4 that is encoded in the genome of Schizosaccharomyces pombe." [PRO:DAN]
comment: Category=organism-family. Note: The hhf1, hhf2, and hhf3 genes encode identical proteins.
synonym: "h4.1" NARROW Gene-based [UniProtKB:P09322]
synonym: "h4.2" NARROW Gene-based [UniProtKB:P09322]
synonym: "h4.3" NARROW Gene-based [UniProtKB:P09322]
synonym: "hhf1" NARROW Gene-based [UniProtKB:P09322]
synonym: "hhf2" NARROW Gene-based [UniProtKB:P09322]
synonym: "hhf3" NARROW Gene-based [UniProtKB:P09322]
synonym: "pi061" RELATED Gene-based [UniProtKB:P09322]
synonym: "Spom-H4" EXACT PRO-short-label [PRO:DAN]
synonym: "SPBC1105.12" NARROW Gene-based [UniProtKB:P09322]
synonym: "SPBC8D2.03c" NARROW Gene-based [UniProtKB:P09322]
synonym: "SPAC1834.03c" NARROW Gene-based [UniProtKB:P09322]
synonym: "Spom-hhf[1/2/3]" EXACT [PRO:DAN]
intersection_of: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
intersection_of: PR:000008603 ! histone H4
union_of: PR:000050526 ! histone H4, hhf1 gene translation product (Schizosaccharomyces pombe)
union_of: PR:000050527 ! histone H4, hhf2 gene translation product (Schizosaccharomyces pombe)
union_of: PR:000050528 ! histone H4, hhf3 gene translation product (Schizosaccharomyces pombe)

[Term]
id: PR:000045317
name: histone H4, initiator methionine removed trimethylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been trimethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-21, MOD:00083." [HIstome_var_Hs:Histone_H4, PMID:15145825, PMID:15765097, PMID:15765097, PMID:20018718, PMID:20495075, PMID:20843831, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K20me3" BROAD [HIstome_ptm_Hs:H4K20me3]
synonym: "hH4/InitMet-/Me3:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-21, MOD:00083" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-21, MOD:00083" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5651656 "PR:000045317 located_in GO:0005654"
xref: TDR:13072
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00083 ! N6,N6,N6-trimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045316
name: histone H4, initiator methionine removed dimethylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-21, MOD:00084." [HIstome_var_Hs:Histone_H4, PMID:15200950, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K20me2" BROAD [HIstome_ptm_Hs:H4K20me2]
synonym: "hH4/InitMet-/Me2:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-21, MOD:00084" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-21, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5651652 "PR:000045316 located_in GO:0005654"
xref: TDR:12674
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045315
name: histone H4, initiator methionine removed ADP-ribosylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been ADP-ribosylated at the position equivalent to Lys-17 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-17, MOD:01399." [HIstome_var_Hs:Histone_H4, PMID:1326536, PMID:1429884, PMID:2387872, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K16ar" BROAD [HIstome_ptm_Hs:H4K16ar]
synonym: "hH4/InitMet-/ADPrib:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-17, MOD:01399" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-17, MOD:01399" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:01399 ! N6-(ADP-ribosyl)-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045319
name: histone H4, initiator methionine removed monomethylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-21, MOD:00085." [HIstome_var_Hs:Histone_H4, PMID:15200950, PMID:16517599, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K20me1" BROAD [HIstome_ptm_Hs:H4K20me1]
synonym: "hH4/InitMet-/Me1:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-21, MOD:00085" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-21, MOD:00085" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2172676 "PR:000045319 located_in GO:0005654"
xref: Reactome:R-HSA-5423110 "PR:000045319 located_in GO:0005654"
xref: TDR:12978
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00085 ! N6-methyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045318
name: histone H4, initiator methionine removed dimethylated 2 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Arg-4, MOD:00783." [HIstome_var_Hs:Histone_H4, PMID:16103216, PMID:19234465, PMID:19234465, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4R3me2" BROAD [HIstome_ptm_Hs:H4R3me2]
synonym: "hH4/InitMet-/Me2:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Arg-4, MOD:00783" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Arg-4, MOD:00783" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00783 ! dimethylated L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P62784
name: histone H4 (worm)
def: "A histone H4 that is encoded in the genome of worm." [OMA:P62784, PRO:DNx]
comment: Category=organism-gene. Note: The his-1, his-5, his-10, his-14, his-18, his-26, his-28, his-31, his-37, his-38, his-46, his-50, his-56, his-60, his-64, and his-67 genes encode identical proteins.
synonym: "his-1" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-5" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-10" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-14" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-18" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-26" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-28" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-31" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-37" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-38" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-46" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-50" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-56" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-60" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-64" RELATED Gene-based [UniProtKB:P62784]
synonym: "his-67" RELATED Gene-based [UniProtKB:P62784]
synonym: "B0035.9" RELATED Gene-based [UniProtKB:P62784]
synonym: "C50F4.7" RELATED Gene-based [UniProtKB:P62784]
synonym: "F07B7.9" RELATED Gene-based [UniProtKB:P62784]
synonym: "F22B3.1" RELATED Gene-based [UniProtKB:P62784]
synonym: "F45F2.3" RELATED Gene-based [UniProtKB:P62784]
synonym: "K03A1.6" RELATED Gene-based [UniProtKB:P62784]
synonym: "K06C4.2" RELATED Gene-based [UniProtKB:P62784]
synonym: "T23D8.5" RELATED Gene-based [UniProtKB:P62784]
synonym: "ZK131.1" RELATED Gene-based [UniProtKB:P62784]
synonym: "ZK131.4" RELATED Gene-based [UniProtKB:P62784]
synonym: "ZK131.8" RELATED Gene-based [UniProtKB:P62784]
synonym: "F17E9.12" RELATED Gene-based [UniProtKB:P62784]
synonym: "F54E12.3" RELATED Gene-based [UniProtKB:P62784]
synonym: "F55G1.11" RELATED Gene-based [UniProtKB:P62784]
synonym: "K06C4.10" RELATED Gene-based [UniProtKB:P62784]
synonym: "T10C6.14" RELATED Gene-based [UniProtKB:P62784]
synonym: "H4 (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P62784
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000008603 ! histone H4
relationship: has_gene_template WormBase:WBGene00001875 ! his-1 (worm)
relationship: has_gene_template WormBase:WBGene00001879 ! his-5 (worm)
relationship: has_gene_template WormBase:WBGene00001884 ! his-10 (worm)
relationship: has_gene_template WormBase:WBGene00001888 ! his-14 (worm)
relationship: has_gene_template WormBase:WBGene00001892 ! his-18 (worm)
relationship: has_gene_template WormBase:WBGene00001900 ! his-26 (worm)
relationship: has_gene_template WormBase:WBGene00001902 ! his-28 (worm)
relationship: has_gene_template WormBase:WBGene00001905 ! his-31 (worm)
relationship: has_gene_template WormBase:WBGene00001911 ! his-37 (worm)
relationship: has_gene_template WormBase:WBGene00001912 ! his-38 (worm)
relationship: has_gene_template WormBase:WBGene00001920 ! his-46 (worm)
relationship: has_gene_template WormBase:WBGene00001924 ! his-50 (worm)
relationship: has_gene_template WormBase:WBGene00001930 ! his-56 (worm)
relationship: has_gene_template WormBase:WBGene00001934 ! his-60 (worm)
relationship: has_gene_template WormBase:WBGene00001938 ! his-64 (worm)
relationship: has_gene_template WormBase:WBGene00001941 ! his-67 (worm)

[Term]
id: PR:000050531
name: histone H4, hhf1 gene translation product, initiator methionine removed trimethylated 1 (Schizosaccharomyces pombe)
def: "A histone H4, hhf1 gene translation product (Schizosaccharomyces pombe) that has had the initiator methionine removed and that has been trimethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P09322. UniProtKB:P09322, 2-103, Lys-21, MOD:00083." [PMID:22150589, PRO:DAN, PomBase:VW]
comment: Category=organism-modification. Requested by=PomBase. Note: Residue numbering for histones typically account for intiiator methionine removal. Hence, Lys-21 of the full sequence as presented in UniProtKB:P09322 is called K20 in the literature.
synonym: "Spom-hhf1/InitMet-/Me3:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000158357, Lys-21, MOD:00083" BROAD PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P09322, 2-103, Lys-21, MOD:00083" BROAD PRO-proteoform-std [PRO:DAN]
synonym: "histone H4 K20me3 (Schizosaccharomyces pombe)" BROAD [PRO:DAN]
synonym: "histone H4 hhf1 K20me3 (Schizosaccharomyces pombe)" EXACT [PRO:DAN]
is_a: PR:000050526 ! histone H4, hhf1 gene translation product (Schizosaccharomyces pombe)
relationship: has_part MOD:00083 ! N6,N6,N6-trimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000050527
name: histone H4, hhf2 gene translation product (Schizosaccharomyces pombe)
def: "A histone H4 (Schizosaccharomyces pombe) that is a translation product of the hhf2 gene in Schizosaccharomyces pombe." [PRO:DAN]
comment: Category=organism-gene. Note: The proteins encoded by hhf1 (PR:000050526), hhf2 (this class), and hhf3 (PR:000050528) are identical.
synonym: "h4.2" RELATED Gene-based [UniProtKB:P09322]
synonym: "hhf2" RELATED Gene-based [UniProtKB:P09322]
synonym: "Spom-hhf2" EXACT PRO-short-label [PRO:DAN]
synonym: "SPAC1834.03c" RELATED Gene-based [UniProtKB:P09322]
intersection_of: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
intersection_of: PR:000050525 ! histone H4 (Schizosaccharomyces pombe)
intersection_of: has_gene_template PomBase:SPBC8D2.03c ! hhf2 (Schizosaccharomyces pombe)

[Term]
id: PR:P59259
name: histone H4 (Arabidopsis thaliana)
def: "A histone H4 that is encoded in the genome of Arabidopsis thaliana." [OMA:P59259, PRO:DNx]
comment: Category=organism-gene. Note: The At1g07660, At1g07820, At3g45930, At3g46320, At3g53730, At5g59690, At5g59970, and HIS4 genes encode identical proteins.
synonym: "At-H4" EXACT PRO-short-label [PRO:DNx]
synonym: "At1g07660" RELATED Gene-based [UniProtKB:P59259]
synonym: "At1g07820" RELATED Gene-based [UniProtKB:P59259]
synonym: "At2g28740" RELATED Gene-based [UniProtKB:P59259]
synonym: "At3g45930" RELATED Gene-based [UniProtKB:P59259]
synonym: "At3g46320" RELATED Gene-based [UniProtKB:P59259]
synonym: "At3g53730" RELATED Gene-based [UniProtKB:P59259]
synonym: "At5g59690" RELATED Gene-based [UniProtKB:P59259]
synonym: "At5g59970" RELATED Gene-based [UniProtKB:P59259]
xref: UniProtKB:P59259
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000008603 ! histone H4
relationship: has_gene_template Araport:AT1G07660 ! At1g07660 (Arabidopsis thaliana)
relationship: has_gene_template Araport:AT1G07820 ! At1g07820 (Arabidopsis thaliana)
relationship: has_gene_template Araport:AT2G28740 ! HIS4 (Arabidopsis thaliana)
relationship: has_gene_template Araport:AT3G45930 ! At3g45930 (Arabidopsis thaliana)
relationship: has_gene_template Araport:AT3G46320 ! At3g46320 (Arabidopsis thaliana)
relationship: has_gene_template Araport:AT3G53730 ! At3g53730 (Arabidopsis thaliana)
relationship: has_gene_template Araport:AT5G59690 ! At5g59690 (Arabidopsis thaliana)
relationship: has_gene_template Araport:AT5G59970 ! At5g59970 (Arabidopsis thaliana)

[Term]
id: PR:000050533
name: histone H4, hhf2 gene translation product, initiator methionine removed dimethylated 1 (Schizosaccharomyces pombe)
def: "A histone H4, hhf2 gene translation product (Schizosaccharomyces pombe) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P09322. UniProtKB:P09322, 2-103, Lys-21, MOD:00084." [PMID:22150589, PRO:DAN, PomBase:VW]
comment: Category=organism-modification. Requested by=PomBase. Note: Residue numbering for histones typically account for intiiator methionine removal. Hence, Lys-21 of the full sequence as presented in UniProtKB:P09322 is called K20 in the literature.
synonym: "Spom-hhf2/InitMet-/Me2:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000158357, Lys-21, MOD:00084" BROAD PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P09322, 2-103, Lys-21, MOD:00084" BROAD PRO-proteoform-std [PRO:DAN]
synonym: "histone H4 K20me2 (Schizosaccharomyces pombe)" BROAD [PRO:DAN]
synonym: "histone H4 hhf2 K20me2 (Schizosaccharomyces pombe)" EXACT [PRO:DAN]
is_a: PR:000050527 ! histone H4, hhf2 gene translation product (Schizosaccharomyces pombe)
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000050530
name: histone H4, hhf1 gene translation product, initiator methionine removed dimethylated 1 (Schizosaccharomyces pombe)
def: "A histone H4, hhf1 gene translation product (Schizosaccharomyces pombe) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P09322. UniProtKB:P09322, 2-103, Lys-21, MOD:00084." [PMID:22150589, PRO:DAN, PomBase:VW]
comment: Category=organism-modification. Requested by=PomBase. Note: Residue numbering for histones typically account for intiiator methionine removal. Hence, Lys-21 of the full sequence as presented in UniProtKB:P09322 is called K20 in the literature.
synonym: "Spom-hhf1/InitMet-/Me2:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000158357, Lys-21, MOD:00084" BROAD PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P09322, 2-103, Lys-21, MOD:00084" BROAD PRO-proteoform-std [PRO:DAN]
synonym: "histone H4 K20me2 (Schizosaccharomyces pombe)" BROAD [PRO:DAN]
synonym: "histone H4 hhf1 K20me2 (Schizosaccharomyces pombe)" EXACT [PRO:DAN]
is_a: PR:000050526 ! histone H4, hhf1 gene translation product (Schizosaccharomyces pombe)
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000050534
name: histone H4, hhf2 gene translation product, initiator methionine removed trimethylated 1 (Schizosaccharomyces pombe)
def: "A histone H4, hhf2 gene translation product (Schizosaccharomyces pombe) that has had the initiator methionine removed and that has been trimethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P09322. UniProtKB:P09322, 2-103, Lys-21, MOD:00083." [PMID:22150589, PRO:DAN, PomBase:VW]
comment: Category=organism-modification. Requested by=PomBase. Note: Residue numbering for histones typically account for intiiator methionine removal. Hence, Lys-21 of the full sequence as presented in UniProtKB:P09322 is called K20 in the literature.
synonym: "Spom-hhf2/InitMet-/Me3:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000158357, Lys-21, MOD:00083" BROAD PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P09322, 2-103, Lys-21, MOD:00083" BROAD PRO-proteoform-std [PRO:DAN]
synonym: "histone H4 K20me3 (Schizosaccharomyces pombe)" BROAD [PRO:DAN]
synonym: "histone H4 hhf2 K20me3 (Schizosaccharomyces pombe)" EXACT [PRO:DAN]
is_a: PR:000050527 ! histone H4, hhf2 gene translation product (Schizosaccharomyces pombe)
relationship: has_part MOD:00083 ! N6,N6,N6-trimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000050532
name: histone H4, hhf2 gene translation product, initiator methionine removed monomethylated 1 (Schizosaccharomyces pombe)
def: "A histone H4, hhf2 gene translation product (Schizosaccharomyces pombe) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P09322. UniProtKB:P09322, 2-103, Lys-21, MOD:00085." [PMID:22150589, PRO:DAN, PomBase:VW]
comment: Category=organism-modification. Requested by=PomBase. Note: Residue numbering for histones typically account for intiiator methionine removal. Hence, Lys-21 of the full sequence as presented in UniProtKB:P09322 is called K20 in the literature.
synonym: "Spom-hhf2/InitMet-/Me1:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000158357, Lys-21, MOD:00085" BROAD PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P09322, 2-103, Lys-21, MOD:00085" BROAD PRO-proteoform-std [PRO:DAN]
synonym: "histone H4 K20me1 (Schizosaccharomyces pombe)" BROAD [PRO:DAN]
synonym: "histone H4 hhf2 K20me1 (Schizosaccharomyces pombe)" EXACT [PRO:DAN]
is_a: PR:000050527 ! histone H4, hhf2 gene translation product (Schizosaccharomyces pombe)
relationship: has_part MOD:00085 ! N6-methyl-L-lysine
relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000050535
name: histone H4, hhf3 gene translation product, initiator methionine removed monomethylated 1 (Schizosaccharomyces pombe)
def: "A histone H4, hhf3 gene translation product (Schizosaccharomyces pombe) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P09322. UniProtKB:P09322, 2-103, Lys-21, MOD:00085." [PMID:22150589, PRO:DAN, PomBase:VW]
comment: Category=organism-modification. Requested by=PomBase. Note: Residue numbering for histones typically account for intiiator methionine removal. Hence, Lys-21 of the full sequence as presented in UniProtKB:P09322 is called K20 in the literature.
synonym: "Spom-hhf3/InitMet-/Me1:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000158357, Lys-21, MOD:00085" BROAD PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P09322, 2-103, Lys-21, MOD:00085" BROAD PRO-proteoform-std [PRO:DAN]
synonym: "histone H4 K20me1 (Schizosaccharomyces pombe)" BROAD [PRO:DAN]
synonym: "histone H4 hhf3 K20me1 (Schizosaccharomyces pombe)" EXACT [PRO:DAN]
is_a: PR:000050528 ! histone H4, hhf3 gene translation product (Schizosaccharomyces pombe)
relationship: has_part MOD:00085 ! N6-methyl-L-lysine
relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P59259-1
name: histone H4 isoform 1 (Arabidopsis thaliana)
def: "A histone H4 isoform 1 that is encoded in the genome of Arabidopsis thaliana." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "At-H4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P59259-1
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000040025 ! histone H4 isoform 1

[Term]
id: PR:000040025
name: histone H4 isoform 1
def: "A histone H4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P62805-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "H4/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000008603 ! histone H4

[Term]
id: PR:000008603
name: histone H4
def: "A core histone that is a translation product of the human HIST4H4 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:DAN]
comment: Category=gene. Note: The human The HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, and HIST4H4 genes encode identical proteins.
synonym: "H4" EXACT PRO-short-label [PRO:DNx]
synonym: "H4/A" RELATED Gene-based []
synonym: "H4/B" RELATED Gene-based []
synonym: "H4/C" RELATED Gene-based []
synonym: "H4/D" RELATED Gene-based []
synonym: "H4/E" RELATED Gene-based []
synonym: "H4/G" RELATED Gene-based []
synonym: "H4/H" RELATED Gene-based []
synonym: "H4/I" RELATED Gene-based []
synonym: "H4/J" RELATED Gene-based []
synonym: "H4/K" RELATED Gene-based []
synonym: "H4/M" RELATED Gene-based []
synonym: "H4/N" RELATED Gene-based []
synonym: "H4/O" RELATED Gene-based []
synonym: "H4C1" RELATED Gene-based []
synonym: "H4C2" RELATED Gene-based []
synonym: "H4C3" RELATED Gene-based []
synonym: "H4C4" RELATED Gene-based []
synonym: "H4C5" RELATED Gene-based []
synonym: "H4C6" RELATED Gene-based []
synonym: "H4C8" RELATED Gene-based []
synonym: "H4C9" RELATED Gene-based []
synonym: "H4F2" RELATED Gene-based []
synonym: "H4FA" RELATED Gene-based []
synonym: "H4FB" RELATED Gene-based []
synonym: "H4FC" RELATED Gene-based []
synonym: "H4FD" RELATED Gene-based []
synonym: "H4FE" RELATED Gene-based []
synonym: "H4FG" RELATED Gene-based []
synonym: "H4FH" RELATED Gene-based []
synonym: "H4FI" RELATED Gene-based []
synonym: "H4FJ" RELATED Gene-based []
synonym: "H4FK" RELATED Gene-based []
synonym: "H4FM" RELATED Gene-based []
synonym: "H4FN" RELATED Gene-based []
synonym: "H4FO" RELATED Gene-based []
synonym: "H4-16" RELATED Gene-based []
synonym: "H4C11" RELATED Gene-based []
synonym: "H4C12" RELATED Gene-based []
synonym: "H4C13" RELATED Gene-based []
synonym: "H4C14" RELATED Gene-based []
synonym: "H4C15" RELATED Gene-based []
synonym: "HIST2H4" RELATED Gene-based []
synonym: "HIST4H4" RELATED Gene-based []
synonym: "HIST1H4A" RELATED Gene-based []
synonym: "HIST1H4B" RELATED Gene-based []
synonym: "HIST1H4C" RELATED Gene-based []
synonym: "HIST1H4D" RELATED Gene-based []
synonym: "HIST1H4E" RELATED Gene-based []
synonym: "HIST1H4F" RELATED Gene-based []
synonym: "HIST1H4H" RELATED Gene-based []
synonym: "HIST1H4I" RELATED Gene-based []
synonym: "HIST1H4J" RELATED Gene-based []
synonym: "HIST1H4K" RELATED Gene-based []
synonym: "HIST1H4L" RELATED Gene-based []
synonym: "HIST2H4A" RELATED Gene-based []
synonym: "HIST2H4B" RELATED Gene-based []
is_a: PR:000043452 ! core histone

[Term]
id: PR:000045328
name: histone H4, initiator methionine removed acetylated 3 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-13 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-13, MOD:00064." [HIstome_var_Hs:Histone_H4, PMID:10958685, PMID:16387653, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K12ac" BROAD [HIstome_ptm_Hs:H4K12ac]
synonym: "hH4/InitMet-/Ac:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-13, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-13, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568744 "PR:000045328 located_in GO:0005654"
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045329
name: histone H4, initiator methionine removed acetylated 4 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-6 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-6, MOD:00064." [HIstome_var_Hs:Histone_H4, PMID:16387653, PMID:18552846, PMID:21272292, PMID:8343956, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K5ac" BROAD [HIstome_ptm_Hs:H4K5ac]
synonym: "hH4/InitMet-/Ac:4" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-6, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-6, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568748 "PR:000045329 located_in GO:0005654"
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045326
name: histone H4, initiator methionine removed acetylated 2 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-92 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-92, MOD:00064." [HIstome_var_Hs:Histone_H4, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K91ac" BROAD [HIstome_ptm_Hs:H4K91ac]
synonym: "hH4/InitMet-/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-92, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-92, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045327
name: histone H4, initiator methionine removed citrullinated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been citrullinated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Arg-4, MOD:00219." [HIstome_var_Hs:Histone_H4, PMID:15345777, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4R3ci" BROAD [HIstome_ptm_Hs:H4R3ci]
synonym: "hH4/InitMet-/Cit:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Arg-4, MOD:00219" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Arg-4, MOD:00219" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00219 ! L-citrulline
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045324
name: histone H4, initiator methionine removed biotinylated 2 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-9 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-9, MOD:00126." [HIstome_var_Hs:Histone_H4, PMID:15153116, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K8bio" BROAD [HIstome_ptm_Hs:H4K8bio]
synonym: "hH4/InitMet-/Btn:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-9, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-9, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045325
name: histone H4, initiator methionine removed ubiquitinated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been ubiquitinated at the position equivalent to Lys-92 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-92, MOD:01148." [HIstome_var_Hs:Histone_H4, PMID:19818714, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K91ub" BROAD [HIstome_ptm_Hs:H4K91ub]
synonym: "hH4/InitMet-/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-92, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-92, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045322
name: histone H4, initiator methionine removed biotinylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-13 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-13, MOD:00126." [HIstome_var_Hs:Histone_H4, PMID:15153116, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K12bio" BROAD [HIstome_ptm_Hs:H4K12bio]
synonym: "hH4/InitMet-/Btn:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-13, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-13, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045323
name: histone H4, initiator methionine removed acetylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-17 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-17, MOD:00064." [HIstome_var_Hs:Histone_H4, PMID:15469825, PMID:15765097, PMID:15765097, PMID:18552846, PMID:20479123, PMID:20525793, PMID:21272292, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K16ac" BROAD [HIstome_ptm_Hs:H4K16ac]
synonym: "hH4/InitMet-/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-17, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-17, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-427469 "PR:000045323 located_in GO:0005654"
xref: Reactome:R-HSA-4568749 "PR:000045323 located_in GO:0005654"
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045320
name: histone H4, initiator methionine removed phosphorylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Ser-2 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Ser-2, MOD:00046." [HIstome_var_Hs:Histone_H4, PMID:15823538, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4S1ph" BROAD [HIstome_ptm_Hs:H4S1ph]
synonym: "hH4/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Ser-2, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Ser-2, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:12345
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045321
name: histone H4, initiator methionine removed monomethylated 2 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Arg-4, MOD:00414." [HIstome_var_Hs:Histone_H4, PMID:11387442, PMID:16103216, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4R3me1" BROAD [HIstome_ptm_Hs:H4R3me1]
synonym: "hH4/InitMet-/Me1:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Arg-4, MOD:00414" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Arg-4, MOD:00414" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00414 ! monomethylated L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine