[Term]
id: PR:Q96A08
name: histone H2B type 1-A (human)
def: "A histone H2B type 1-A that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q96A08]
comment: Category=organism-gene.
synonym: "H2BC1" RELATED Gene-based [UniProtKB:Q96A08]
synonym: "TSH2B" RELATED Gene-based [UniProtKB:Q96A08]
synonym: "hH2BC1" EXACT PRO-short-label [PRO:DNx]
synonym: "hTSH2B" EXACT [UniProtKB:Q96A08]
synonym: "HIST1H2BA" RELATED Gene-based [UniProtKB:Q96A08]
synonym: "TSH2B.1 (human)" EXACT [UniProtKB:Q96A08]
synonym: "histone H2B, testis (human)" EXACT [UniProtKB:Q96A08]
synonym: "testis-specific histone H2B (human)" EXACT [UniProtKB:Q96A08]
xref: UniProtKB:Q96A08
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008586 ! histone H2B type 1-A
relationship: has_gene_template HGNC:18730 ! H2BC1 (human)

[Term]
id: PR:000036256
name: histone H2B type 1-A acetylated 1 (human)
def: "A histone H2B type 1-A that is N-terminal Met acetylated in human. UniProtKB:Q96A08, Met-1, MOD:00058." [TDR:5019]
comment: Category=organism-modification. Note: Top down proteomics. Evidence=(ECO:0000006).
synonym: "hHIST1H2BA/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q96A08, Met-1, MOD:00058" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:5019
is_a: PR:000008586 ! histone H2B type 1-A
relationship: has_part MOD:00058 ! N-acetyl-L-methionine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047756
name: histone H2B type 1-A, initiator methionine removed acetylated 4 (human)
def: "A histone H2B type 1-A (human) that has had the initiator methionine removed and has been post-translationally modified to include N6-acetyllysine at position 22 of the amino acid sequence represented by UniProtKB:Q96A08. UniProtKB:Q96A08, 2-127, Lys-22, MOD:00064." [PRO:DNx, Reactome:R-HSA-4568647]
comment: Category=organism-modification.
synonym: "hHIST1H2BA/InitMet-/Ac:4" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071842, Lys-22, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q96A08, 2-127, Lys-22, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568647 "PR:000047756 located_in GO:0005654"
is_a: PR:Q96A08 ! histone H2B type 1-A (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000047755
name: histone H2B type 1-A, initiator methionine removed acetylated 3 (human)
def: "A histone H2B type 1-A (human) that has had the initiator methionine removed and has been post-translationally modified to include N6-acetyllysine at position 17 of the amino acid sequence represented by UniProtKB:Q96A08. UniProtKB:Q96A08, 2-127, Lys-17, MOD:00064." [PRO:DNx, Reactome:R-HSA-4568631]
comment: Category=organism-modification.
synonym: "hHIST1H2BA/InitMet-/Ac:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071842, Lys-17, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q96A08, 2-127, Lys-17, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568631 "PR:000047755 located_in GO:0005654"
is_a: PR:Q96A08 ! histone H2B type 1-A (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000047754
name: histone H2B type 1-A, initiator methionine removed acetylated 2 (human)
def: "A histone H2B type 1-A (human) that has had the initiator methionine removed and has been post-translationally modified to include N6-acetyllysine at position 14 of the amino acid sequence represented by UniProtKB:Q96A08. UniProtKB:Q96A08, 2-127, Lys-14, MOD:00064." [PRO:DNx, Reactome:R-HSA-4568615]
comment: Category=organism-modification.
synonym: "hHIST1H2BA/InitMet-/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071842, Lys-14, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q96A08, 2-127, Lys-14, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568615 "PR:000047754 located_in GO:0005654"
is_a: PR:Q96A08 ! histone H2B type 1-A (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000047757
name: histone H2B type 1-A, initiator methionine removed acetylated 5 (human)
def: "A histone H2B type 1-A (human) that has had the initiator methionine removed and has been post-translationally modified to include N6-acetyllysine at position 7 of the amino acid sequence represented by UniProtKB:Q96A08. UniProtKB:Q96A08, 2-127, Lys-7, MOD:00064." [PRO:DNx, Reactome:R-HSA-4568624]
comment: Category=organism-modification.
synonym: "hHIST1H2BA/InitMet-/Ac:5" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071842, Lys-7, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q96A08, 2-127, Lys-7, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568624 "PR:000047757 located_in GO:0005654"
is_a: PR:Q96A08 ! histone H2B type 1-A (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000008586
name: histone H2B type 1-A
def: "A histone H2B that is a translation product of the human H2BC1 gene or a 1:1 ortholog thereof." [PRO:DAN]
comment: Category=gene.
synonym: "Th2b" RELATED Gene-based []
synonym: "H2BC1" EXACT PRO-short-label [PRO:DNx]
synonym: "TSH2B" RELATED Gene-based []
synonym: "HIST1H2BA" RELATED Gene-based []
synonym: "histone H2B, testis" EXACT []
synonym: "testis-specific histone H2B" EXACT []
is_a: PR:000036509 ! histone H2B

[Term]
id: PR:000047753
name: histone H2B type 1-A, initiator methionine removed form (human)
def: "A histone H2B type 1-A (human) that has had the initiator methionine removed. UniProtKB:Q96A08, 2-127." [PRO:DNx, Reactome:R-HSA-181916, Reactome:R-HSA-977582]
comment: Category=organism-modification.
synonym: "PRO_0000071842" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2BA/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q96A08, 2-127" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-181916 "PR:000047753 located_in GO:0005654"
xref: Reactome:R-HSA-977582 "PR:000047753 located_in GO:0005576"
xref: TDR:2767
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q96A08 ! histone H2B type 1-A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96A08-1
name: histone H2B type 1-A isoform 1 (human)
def: "A histone H2B type 1-A isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hHIST1H2BA/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96A08-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000042410 ! histone H2B type 1-A isoform 1

[Term]
id: PR:000047760
name: histone H2B type 1-A, initiator methionine removed ubiquitinated 1 (human)
def: "A histone H2B type 1-A (human) that has had the initiator methionine removed and has been post-translationally modified to include ubiquitinated lysine at position 122 of the amino acid sequence represented by UniProtKB:Q96A08. UniProtKB:Q96A08, 2-127, Lys-122, MOD:01148." [PRO:DAN, Reactome:R-HSA-3364020]
comment: Category=organism-modification. Note: A correction of the sequence numbering of the source data (Reactome:R-HSA-3364020) rendered PR:000047759 identical to this entry
synonym: "hHIST1H2BA/InitMet-/Ubiq:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071842, Lys-122, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q96A08, 2-127, Lys-122, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3364020 "PR:000047760 located_in GO:0005654"
is_a: PR:Q96A08 ! histone H2B type 1-A (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000047758
name: histone H2B type 1-A, initiator methionine removed N6-acetyllysine form (human)
def: "A histone H2B type 1-A (human) that has had the initiator methionine removed and that includes at least one N6-acetyllysine. UniProtKB:Q96A08, 2-127, MOD:00064." [PRO:DNx, Reactome:R-HSA-4549263]
comment: Category=organism-modification.
synonym: "PRO_0000071842, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2BA/InitMet-/N6AcLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q96A08, 2-127, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4549263 "PR:000047758 located_in GO:0005654"
intersection_of: has_part MOD:00064 ! N6-acetyl-L-lysine
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q96A08 ! histone H2B type 1-A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens