[Term]
id: PR:000028784
name: hypermethylated in cancer 1 protein isoform 2 acetylated 1 (human)
def: "A hypermethylated in cancer 1 protein isoform 2 acetylated 1 in human. Acetylation regulates transcriptional repression activity. UniProtKB:Q14526-2, Lys-314, MOD:00064." [PMID:17283066, PRO:PD]
comment: Category=organism-modification.
synonym: "hHIC1/iso:2/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14526-2, Lys-314, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028783 ! hypermethylated in cancer 1 protein isoform 2 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:Q9R1Y5
name: hypermethylated in cancer 1 protein (mouse)
def: "A hypermethylated in cancer 1 protein that is encoded in the genome of mouse." [OMA:Q9R1Y5, PRO:DNx]
comment: Category=organism-gene.
synonym: "Hic1" RELATED Gene-based [UniProtKB:Q9R1Y5]
synonym: "mHIC1" EXACT PRO-short-label [PRO:DNx]
synonym: "Hic-1 (mouse)" EXACT [UniProtKB:Q9R1Y5]
xref: UniProtKB:Q9R1Y5
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008551 ! hypermethylated in cancer 1 protein
relationship: has_gene_template MGI:1338010 ! Hic1 (mouse)

[Term]
id: PR:Q14526-2
name: hypermethylated in cancer 1 protein isoform 2 (human)
def: "A hypermethylated in cancer 1 protein isoform 2 that is encoded in the genome of human." [PRO:PD]
comment: Category=organism-sequence.
synonym: "hHIC1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q14526-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028781 ! hypermethylated in cancer 1 protein isoform 2

[Term]
id: PR:Q14526-1
name: hypermethylated in cancer 1 protein isoform 1 (human)
def: "A hypermethylated in cancer 1 protein isoform 1 that is encoded in the genome of human." [PRO:PD]
comment: Category=organism-sequence.
synonym: "hHIC1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q14526-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028779 ! hypermethylated in cancer 1 protein isoform 1

[Term]
id: PR:000028779
name: hypermethylated in cancer 1 protein isoform 1
def: "A hypermethylated in cancer 1 protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14526-1 or a 1:1 ortholog thereof." [PMID:17283066, PRO:PD]
comment: Category=sequence.
synonym: "HIC1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000008551 ! hypermethylated in cancer 1 protein

[Term]
id: PR:Q14526
name: hypermethylated in cancer 1 protein (human)
def: "A hypermethylated in cancer 1 protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q14526]
comment: Category=organism-gene.
synonym: "HIC1" RELATED Gene-based [UniProtKB:Q14526]
synonym: "hHIC1" EXACT PRO-short-label [PRO:DNx]
synonym: "ZBTB29" RELATED Gene-based [UniProtKB:Q14526]
synonym: "Hic-1 (human)" EXACT [UniProtKB:Q14526]
synonym: "zinc finger and BTB domain-containing protein 29 (human)" EXACT [UniProtKB:Q14526]
xref: Reactome:R-HSA-4090364 "PR:Q14526 located_in GO:0005654"
xref: UniProtKB:Q14526
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008551 ! hypermethylated in cancer 1 protein
relationship: has_gene_template HGNC:4909 ! HIC1 (human)

[Term]
id: PR:000028781
name: hypermethylated in cancer 1 protein isoform 2
def: "A hypermethylated in cancer 1 protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14526-2 or a 1:1 ortholog thereof." [PMID:17283066, PRO:PD]
comment: Category=sequence.
synonym: "HIC1/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000008551 ! hypermethylated in cancer 1 protein

[Term]
id: PR:Q9R1Y5-1
name: hypermethylated in cancer 1 protein isoform m1 (mouse)
def: "A hypermethylated in cancer 1 protein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9R1Y5-1." [PRO:DNx, UniProtKB:Q9R1Y5]
comment: Category=organism-sequence.
synonym: "mHIC1/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9R1Y5-1
is_a: PR:Q9R1Y5 ! hypermethylated in cancer 1 protein (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000028783
name: hypermethylated in cancer 1 protein isoform 2 acetylated 1
def: "A hypermethylated in cancer 1 protein isoform 2 that has been acetylated on a Lys residue present in the YRWM/VKXEP motif situated within the central repression domain. Example: UniProtKB:Q14526-2, Lys-314, MOD:00064." [PMID:17283066, PRO:PD]
comment: Category=modification.
synonym: "HIC1/iso:2/Ac:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000028781 ! hypermethylated in cancer 1 protein isoform 2
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000008551
name: hypermethylated in cancer 1 protein
def: "A protein that is a translation product of the human HIC1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "HIC1" EXACT PRO-short-label [PRO:DNx]
synonym: "Hic-1" EXACT []
synonym: "ZBTB29" RELATED Gene-based []
synonym: "zinc finger and BTB domain-containing protein 29" EXACT []
is_a: PR:000000001 ! protein