[Term]
id: PR:000025889
name: tyrosine-protein kinase HCK phosphorylated 1 (human)
def: "A tyrosine-protein kinase HCK phosphorylated 1 in human. UniProtKB:P08631, Tyr-522, MOD:00048." [OCA:JP, PMID:10360180]
comment: Category=organism-modification.
synonym: "hHCK/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08631, Tyr-522, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: PDB:1QCF
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025888 ! tyrosine-protein kinase HCK phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000025888
name: tyrosine-protein kinase HCK phosphorylated 1
def: "A tyrosine-protein kinase HCK that has been phosphorylated at the position equivalent to Tyr-522 of the amino acid sequence represented by UniProtKB:P08631. Example: UniProtKB:P08631, Tyr-522, MOD:00048." [PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "HCK/Phos:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00048 ! O4'-phospho-L-tyrosine
intersection_of: PR:000008473 ! tyrosine-protein kinase HCK

[Term]
id: PR:P08631
name: tyrosine-protein kinase HCK (human)
def: "A tyrosine-protein kinase HCK that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08631]
comment: Category=organism-gene.
synonym: "HCK" RELATED Gene-based [UniProtKB:P08631]
synonym: "hHCK" EXACT PRO-short-label [PRO:DNx]
synonym: "p59Hck (human)" EXACT [UniProtKB:P08631]
synonym: "p61Hck (human)" EXACT [UniProtKB:P08631]
synonym: "p59-HCK/p60-HCK (human)" EXACT [UniProtKB:P08631]
synonym: "hemopoietic cell kinase (human)" EXACT [UniProtKB:P08631]
synonym: "hematopoietic cell kinase (human)" EXACT [UniProtKB:P08631]
xref: DTO:03100171
xref: UniProtKB:P08631
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008473 ! tyrosine-protein kinase HCK
relationship: has_gene_template HGNC:4840 ! HCK (human)

[Term]
id: PR:P50545-1
name: tyrosine-protein kinase HCK isoform 1 (rat)
def: "A tyrosine-protein kinase HCK isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rHCK/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase HCK isoform p59-HCK (rat)" EXACT [UniProtKB:P50545]
xref: UniProtKB:P50545-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038730 ! tyrosine-protein kinase HCK isoform 1

[Term]
id: PR:P50545-2
name: tyrosine-protein kinase HCK isoform 2 (rat)
def: "A tyrosine-protein kinase HCK isoform 2 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rHCK/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase HCK isoform p56-HCK (rat)" EXACT [UniProtKB:P50545]
xref: UniProtKB:P50545-2
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038731 ! tyrosine-protein kinase HCK isoform 2

[Term]
id: PR:000008473
name: tyrosine-protein kinase HCK
def: "A proto-oncogene SRC-like tyrosine-protein kinase that is a translation product of the human HCK gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "BMK" EXACT []
synonym: "HCK" EXACT PRO-short-label [PRO:DNx]
synonym: "p56-HCK/p59-HCK" EXACT []
synonym: "p59-HCK/p60-HCK" EXACT []
synonym: "B-cell/myeloid kinase" EXACT []
synonym: "hemopoietic cell kinase" EXACT []
synonym: "hematopoietic cell kinase" EXACT []
xref: IUPHARobj:2032
is_a: PR:000002997 ! proto-oncogene SRC-like tyrosine-protein kinase

[Term]
id: PR:000038731
name: tyrosine-protein kinase HCK isoform 2
def: "A tyrosine-protein kinase HCK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08103-2 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "HCK/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000008473 ! tyrosine-protein kinase HCK

[Term]
id: PR:000038730
name: tyrosine-protein kinase HCK isoform 1
def: "A tyrosine-protein kinase HCK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08103-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "HCK/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000008473 ! tyrosine-protein kinase HCK

[Term]
id: PR:000047689
name: tyrosine-protein kinase HCK, initiator methionine removed form (human)
def: "A tyrosine-protein kinase HCK (human) that has had the initiator methionine removed. UniProtKB:P08631, 2-526." [PRO:DNx, Reactome:R-HSA-167708]
comment: Category=organism-modification.
synonym: "hHCK/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000024433" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P08631, 2-526" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-167708 "PR:000047689 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P08631 ! tyrosine-protein kinase HCK (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08103
name: tyrosine-protein kinase HCK (mouse)
def: "A tyrosine-protein kinase HCK that is encoded in the genome of mouse." [OMA:P08103, PRO:DNx]
comment: Category=organism-gene.
synonym: "Hck" RELATED Gene-based [UniProtKB:P08103]
synonym: "mHCK" EXACT PRO-short-label [PRO:DNx]
synonym: "BMK (mouse)" EXACT [UniProtKB:P08103]
synonym: "p56-HCK/p59-HCK (mouse)" EXACT [UniProtKB:P08103]
synonym: "B-cell/myeloid kinase (mouse)" EXACT [UniProtKB:P08103]
synonym: "hemopoietic cell kinase (mouse)" EXACT [UniProtKB:P08103]
synonym: "hematopoietic cell kinase (mouse)" EXACT [UniProtKB:P08103]
xref: UniProtKB:P08103
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008473 ! tyrosine-protein kinase HCK
relationship: has_gene_template MGI:96052 ! Hck (mouse)

[Term]
id: PR:P08631-2
name: tyrosine-protein kinase HCK isoform h2 (human)
def: "A tyrosine-protein kinase HCK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08631-2." [PRO:DNx, UniProtKB:P08631]
comment: Category=organism-sequence.
synonym: "hHCK/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase HCK isoform p59Hck (human)" EXACT [UniProtKB:P08631]
synonym: "tyrosine-protein kinase HCK isoform p59-HCK (human)" EXACT [UniProtKB:P08631]
xref: UniProtKB:P08631-2
is_a: PR:P08631 ! tyrosine-protein kinase HCK (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P50545
name: tyrosine-protein kinase HCK (rat)
def: "A tyrosine-protein kinase HCK that is encoded in the genome of rat." [OMA:P50545, PANTHER:PTHR24418:SF259, PRO:DNx]
comment: Category=organism-gene.
synonym: "Hck" RELATED Gene-based [UniProtKB:P50545]
synonym: "rHCK" EXACT PRO-short-label [PRO:DNx]
synonym: "p56Hck (rat)" EXACT [UniProtKB:P50545]
synonym: "p59Hck (rat)" EXACT [UniProtKB:P50545]
synonym: "p56-HCK (rat)" EXACT [UniProtKB:P50545]
synonym: "hemopoietic cell kinase (rat)" EXACT [UniProtKB:P50545]
synonym: "hematopoietic cell kinase (rat)" EXACT [UniProtKB:P50545]
xref: UniProtKB:P50545
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000008473 ! tyrosine-protein kinase HCK
relationship: has_gene_template RGD:2785 ! Hck (rat)

[Term]
id: PR:P08631-4
name: tyrosine-protein kinase HCK isoform h4 (human)
def: "A tyrosine-protein kinase HCK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08631-4." [PRO:DNx, UniProtKB:P08631]
comment: Category=organism-sequence.
synonym: "hHCK/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08631-4
is_a: PR:P08631 ! tyrosine-protein kinase HCK (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08631-1
name: tyrosine-protein kinase HCK isoform h1 (human)
def: "A tyrosine-protein kinase HCK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08631-1." [PRO:DNx, UniProtKB:P08631]
comment: Category=organism-sequence.
synonym: "hHCK/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase HCK isoform p61Hck (human)" EXACT [UniProtKB:P08631]
synonym: "tyrosine-protein kinase HCK isoform p60-HCK (human)" EXACT [UniProtKB:P08631]
xref: UniProtKB:P08631-1
is_a: PR:P08631 ! tyrosine-protein kinase HCK (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08103-2
name: tyrosine-protein kinase HCK isoform 2 (mouse)
def: "A tyrosine-protein kinase HCK isoform 2 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mHCK/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase HCK isoform p56-HCK (mouse)" EXACT [UniProtKB:P08103]
xref: UniProtKB:P08103-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038731 ! tyrosine-protein kinase HCK isoform 2

[Term]
id: PR:P08631-3
name: tyrosine-protein kinase HCK isoform h3 (human)
def: "A tyrosine-protein kinase HCK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08631-3." [PRO:DNx, UniProtKB:P08631]
comment: Category=organism-sequence.
synonym: "hHCK/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08631-3
is_a: PR:P08631 ! tyrosine-protein kinase HCK (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08103-1
name: tyrosine-protein kinase HCK isoform 1 (mouse)
def: "A tyrosine-protein kinase HCK isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mHCK/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase HCK isoform p59-HCK (mouse)" EXACT [UniProtKB:P08103]
xref: UniProtKB:P08103-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038730 ! tyrosine-protein kinase HCK isoform 1