[Term]
id: PR:Q99075
name: proheparin-binding EGF-like growth factor (human)
def: "A proheparin-binding EGF-like growth factor that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q99075]
comment: Category=organism-gene.
synonym: "DTR" RELATED Gene-based [UniProtKB:Q99075]
synonym: "DTS" RELATED Gene-based [UniProtKB:Q99075]
synonym: "HBEGF" RELATED Gene-based [UniProtKB:Q99075]
synonym: "HEGFL" RELATED Gene-based [UniProtKB:Q99075]
synonym: "hHBEGF" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99075
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008459 ! proheparin-binding EGF-like growth factor
relationship: has_gene_template HGNC:3059 ! HBEGF (human)

[Term]
id: PR:Q06186-1
name: proheparin-binding EGF-like growth factor isoform 1 (mouse)
def: "A proheparin-binding EGF-like growth factor isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mHBEGF/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q06186-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000042693 ! proheparin-binding EGF-like growth factor isoform 1

[Term]
id: PR:000020117
name: proheparin-binding EGF-like growth factor proteolytic cleavage product
def: "A proheparin-binding EGF-like growth factor that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "HBEGF/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000008459 ! proheparin-binding EGF-like growth factor

[Term]
id: PR:000057923
name: proheparin-binding EGF-like growth factor O-glycosylated 2 (human)
def: "A proheparin-binding EGF-like growth factor (human) that has been O-glycosylated at the residue equivalent to Thr-44 of the amino acid sequence represented by UniProtKB:Q99075-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q99075-1, Thr-44, MOD:00005~GNO:G43417UB." [GlyGen:Q99075-1, PMID:22171320, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hHBEGF/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99075-1, Thr-44, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q99075 ! proheparin-binding EGF-like growth factor (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000057922
name: proheparin-binding EGF-like growth factor O-glycosylated 1 (human)
def: "A proheparin-binding EGF-like growth factor (human) that has been O-glycosylated at the residue equivalent to Thr-37 of the amino acid sequence represented by UniProtKB:Q99075-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q99075-1, Thr-37, MOD:00005~GNO:G53434XO." [GlyGen:Q99075-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hHBEGF/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99075-1, Thr-37, MOD:00005~GNO:G53434XO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q99075 ! proheparin-binding EGF-like growth factor (human)
relationship: has_part GNO:G53434XO ! G53434XO
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9W7C5
name: proheparin-binding EGF-like growth factor (chicken)
def: "A proheparin-binding EGF-like growth factor that is encoded in the genome of chicken." [OMA:Q9W7C5, PANTHER:PTHR10740:SF4, PRO:DNx]
comment: Category=organism-gene.
synonym: "HBEGF" RELATED Gene-based [UniProtKB:Q9W7C5]
synonym: "HEGFL" RELATED Gene-based [UniProtKB:Q9W7C5]
synonym: "chick-HBEGF" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9W7C5
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000008459 ! proheparin-binding EGF-like growth factor
relationship: has_gene_template NCBIGene:395654 ! HBEGF (chicken)

[Term]
id: PR:Q06186
name: proheparin-binding EGF-like growth factor (mouse)
def: "A proheparin-binding EGF-like growth factor that is encoded in the genome of mouse." [OMA:Q06186, PRO:DNx]
comment: Category=organism-gene.
synonym: "Dtr" RELATED Gene-based [UniProtKB:Q06186]
synonym: "Hbegf" RELATED Gene-based [UniProtKB:Q06186]
synonym: "Hegfl" RELATED Gene-based [UniProtKB:Q06186]
synonym: "mHBEGF" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q06186
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008459 ! proheparin-binding EGF-like growth factor
relationship: has_gene_template MGI:96070 ! Hbegf (mouse)

[Term]
id: PR:000057926
name: proheparin-binding EGF-like growth factor O-glycosylated 5 (human)
def: "A proheparin-binding EGF-like growth factor (human) that has been O-glycosylated at the residue equivalent to Thr-47 of the amino acid sequence represented by UniProtKB:Q99075-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q99075-1, Thr-47, MOD:00005~GNO:G53434XO." [GlyGen:Q99075-1, PMID:22171320, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hHBEGF/OGlyco:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99075-1, Thr-47, MOD:00005~GNO:G53434XO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q99075 ! proheparin-binding EGF-like growth factor (human)
relationship: has_part GNO:G53434XO ! G53434XO
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000057925
name: proheparin-binding EGF-like growth factor O-glycosylated 4 (human)
def: "A proheparin-binding EGF-like growth factor (human) that has been O-glycosylated at the residue equivalent to Thr-47 of the amino acid sequence represented by UniProtKB:Q99075-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q99075-1, Thr-47, MOD:00005~GNO:G43417UB." [GlyGen:Q99075-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hHBEGF/OGlyco:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99075-1, Thr-47, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q99075 ! proheparin-binding EGF-like growth factor (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000057924
name: proheparin-binding EGF-like growth factor O-glycosylated 3 (human)
def: "A proheparin-binding EGF-like growth factor (human) that has been O-glycosylated at the residue equivalent to Thr-44 of the amino acid sequence represented by UniProtKB:Q99075-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q99075-1, Thr-44, MOD:00005~GNO:G53434XO." [GlyGen:Q99075-1, PMID:22171320, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hHBEGF/OGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99075-1, Thr-44, MOD:00005~GNO:G53434XO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q99075 ! proheparin-binding EGF-like growth factor (human)
relationship: has_part GNO:G53434XO ! G53434XO
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000008459
name: proheparin-binding EGF-like growth factor
def: "A protein that is a translation product of the human HBEGF gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "DTR" RELATED Gene-based []
synonym: "DTS" RELATED Gene-based []
synonym: "HBEGF" EXACT PRO-short-label [PRO:DNx]
synonym: "HEGFL" RELATED Gene-based []
is_a: PR:000000001 ! protein

[Term]
id: PR:000042693
name: proheparin-binding EGF-like growth factor isoform 1
def: "A proheparin-binding EGF-like growth factor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99075-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "HBEGF/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000008459 ! proheparin-binding EGF-like growth factor

[Term]
id: PR:Q06175
name: proheparin-binding EGF-like growth factor (rat)
def: "A proheparin-binding EGF-like growth factor that is encoded in the genome of rat." [OMA:Q06175, PANTHER:PTHR10740:SF4, PRO:DNx]
comment: Category=organism-gene.
synonym: "Dtr" RELATED Gene-based [UniProtKB:Q06175]
synonym: "Hbegf" RELATED Gene-based [UniProtKB:Q06175]
synonym: "Hegfl" RELATED Gene-based [UniProtKB:Q06175]
synonym: "rHBEGF" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q06175
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000008459 ! proheparin-binding EGF-like growth factor
relationship: has_gene_template RGD:2526 ! Hbegf (rat)

[Term]
id: PR:Q99075-1
name: proheparin-binding EGF-like growth factor isoform 1 (human)
def: "A proheparin-binding EGF-like growth factor isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hHBEGF/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99075-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000042693 ! proheparin-binding EGF-like growth factor isoform 1

[Term]
id: PR:000047684
name: proheparin-binding EGF-like growth factor, signal peptide removed form (human)
def: "A proheparin-binding EGF-like growth factor (human) that has had the signal peptide removed. UniProtKB:Q99075, 20-208." [PRO:DNx, Reactome:R-HSA-2179406, Reactome:R-HSA-5334771, Reactome:R-HSA-5334776, Reactome:R-HSA-5334782]
comment: Category=organism-modification.
synonym: "PRO_0000302803" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHBEGF/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99075, 20-208" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2179406 "PR:000047684 located_in GO:0005576"
xref: Reactome:R-HSA-5334771 "PR:000047684 located_in GO:0005886"
xref: Reactome:R-HSA-5334776 "PR:000047684 located_in GO:0030666"
xref: Reactome:R-HSA-5334782 "PR:000047684 located_in GO:0030669"
intersection_of: PR:Q99075 ! proheparin-binding EGF-like growth factor (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q06175-1
name: proheparin-binding EGF-like growth factor isoform 1 (rat)
def: "A proheparin-binding EGF-like growth factor isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rHBEGF/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q06175-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000042693 ! proheparin-binding EGF-like growth factor isoform 1