[Term]
id: PR:Q8TDQ0-1
name: hepatitis A virus cellular receptor 2 isoform h1 (human)
def: "A hepatitis A virus cellular receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TDQ0-1." [PRO:DNx, UniProtKB:Q8TDQ0]
comment: Category=organism-sequence.
synonym: "hHAVCR2/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8TDQ0-1
is_a: PR:Q8TDQ0 ! hepatitis A virus cellular receptor 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8TDQ0-2
name: hepatitis A virus cellular receptor 2 isoform h2 (human)
def: "A hepatitis A virus cellular receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TDQ0-2." [PRO:DNx, UniProtKB:Q8TDQ0]
comment: Category=organism-sequence.
synonym: "hHAVCR2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8TDQ0-2
is_a: PR:Q8TDQ0 ! hepatitis A virus cellular receptor 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8TDQ0
name: hepatitis A virus cellular receptor 2 (human)
def: "A hepatitis A virus cellular receptor 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8TDQ0]
comment: Category=organism-gene.
synonym: "TIM3" RELATED Gene-based [UniProtKB:Q8TDQ0]
synonym: "TIMD3" RELATED Gene-based [UniProtKB:Q8TDQ0]
synonym: "HAVCR2" RELATED Gene-based [UniProtKB:Q8TDQ0]
synonym: "hHAVCR2" EXACT PRO-short-label [PRO:DNx]
synonym: "CD366 (human)" EXACT [UniProtKB:Q8TDQ0]
synonym: "TIM-3 (human)" EXACT [UniProtKB:Q8TDQ0]
synonym: "TIMD-3 (human)" EXACT [UniProtKB:Q8TDQ0]
synonym: "HAVcr-2 (human)" EXACT [UniProtKB:Q8TDQ0]
synonym: "T-cell membrane protein 3 (human)" EXACT [UniProtKB:Q8TDQ0]
synonym: "T-cell immunoglobulin mucin receptor 3 (human)" EXACT [UniProtKB:Q8TDQ0]
synonym: "T-cell immunoglobulin and mucin domain-containing protein 3 (human)" EXACT [UniProtKB:Q8TDQ0]
xref: UniProtKB:Q8TDQ0
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008454 ! hepatitis A virus cellular receptor 2
relationship: has_gene_template HGNC:18437 ! HAVCR2 (human)

[Term]
id: PR:000057733
name: hepatitis A virus cellular receptor 2 O-glycosylated 1 (human)
def: "A hepatitis A virus cellular receptor 2 (human) that has been O-glycosylated at the residue equivalent to Thr-145 of the amino acid sequence represented by UniProtKB:Q8TDQ0-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q8TDQ0-1, Thr-145, MOD:00005~GNO:G43417UB." [GlyGen:Q8TDQ0-1, PMID:22171320, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hHAVCR2/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8TDQ0-1, Thr-145, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q8TDQ0 ! hepatitis A virus cellular receptor 2 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046002
name: hepatitis A virus cellular receptor 2 phosphorylated 1 (human)
def: "A hepatitis A virus cellular receptor 2 (human) that has been phosphorylated at the position equivalent to Tyr-265 of the amino acid sequence represented by UniProtKB:Q8TDQ0-1. Example: UniProtKB:Q8TDQ0-1, Tyr-265, MOD:00048." [PMID:17069754, iPTMnet:Q8TDQ0]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:17069754). Status=unreviewed.
synonym: "hHAVCR2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8TDQ0-1, Tyr-265, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q8TDQ0 ! hepatitis A virus cellular receptor 2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000057734
name: hepatitis A virus cellular receptor 2 O-glycosylated 2 (human)
def: "A hepatitis A virus cellular receptor 2 (human) that has been O-glycosylated at the residue equivalent to Thr-174 of the amino acid sequence represented by UniProtKB:Q8TDQ0-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q8TDQ0-1, Thr-174, MOD:00005~GNO:G43417UB." [GlyGen:Q8TDQ0-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hHAVCR2/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8TDQ0-1, Thr-174, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q8TDQ0 ! hepatitis A virus cellular receptor 2 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000057735
name: hepatitis A virus cellular receptor 2 O-glycosylated 3 (human)
def: "A hepatitis A virus cellular receptor 2 (human) that has been O-glycosylated at the residue equivalent to Thr-178 of the amino acid sequence represented by UniProtKB:Q8TDQ0-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q8TDQ0-1, Thr-178, MOD:00005~GNO:G43417UB." [GlyGen:Q8TDQ0-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hHAVCR2/OGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8TDQ0-1, Thr-178, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q8TDQ0 ! hepatitis A virus cellular receptor 2 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000008454
name: hepatitis A virus cellular receptor 2
def: "A protein that is a translation product of the human HAVCR2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "TIM3" RELATED Gene-based []
synonym: "CD366" EXACT []
synonym: "TIM-3" EXACT []
synonym: "TIMD3" RELATED Gene-based []
synonym: "HAVCR2" EXACT PRO-short-label [PRO:DNx]
synonym: "TIMD-3" EXACT []
synonym: "HAVcr-2" EXACT []
synonym: "T-cell membrane protein 3" EXACT []
synonym: "T-cell immunoglobulin mucin receptor 3" EXACT []
synonym: "T-cell immunoglobulin and mucin domain-containing protein 3" EXACT []
xref: IUPHARobj:2940
is_a: PR:000000001 ! protein

[Term]
id: PR:000047680
name: hepatitis A virus cellular receptor 2, signal peptide removed form (human)
def: "A hepatitis A virus cellular receptor 2 (human) that has had the signal peptide removed. UniProtKB:Q8TDQ0, 22-301." [PRO:DNx, Reactome:R-HSA-5340408]
comment: Category=organism-modification.
synonym: "PRO_0000042101" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHAVCR2/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8TDQ0, 22-301" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5340408 "PR:000047680 located_in GO:0005886"
intersection_of: PR:Q8TDQ0 ! hepatitis A virus cellular receptor 2 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens