[Term]
id: PR:000026787
name: growth factor receptor-bound protein 2 isoform 1
def: "A growth factor receptor-bound protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P62993-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "GRB2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000008224 ! growth factor receptor-bound protein 2

[Term]
id: PR:P62993
name: growth factor receptor-bound protein 2 (human)
def: "A growth factor receptor-bound protein 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P62993]
comment: Category=organism-gene.
synonym: "ASH" RELATED Gene-based [UniProtKB:P62993]
synonym: "GRB2" RELATED Gene-based [UniProtKB:P62993]
synonym: "hGRB2" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Ash (human)" EXACT [UniProtKB:P62993]
synonym: "SH2/SH3 adapter GRB2 (human)" EXACT [UniProtKB:P62993]
synonym: "adapter protein GRB2 (human)" EXACT [UniProtKB:P62993]
xref: UniProtKB:P62993
xref: Reactome:R-HSA-8983328 "PR:P62993 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008224 ! growth factor receptor-bound protein 2
relationship: has_gene_template HGNC:4566 ! GRB2 (human)

[Term]
id: PR:000040057
name: growth factor receptor-bound protein 2 isoform 2
def: "A growth factor receptor-bound protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P62993-2 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "GRB2/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000008224 ! growth factor receptor-bound protein 2

[Term]
id: PR:P62994
name: growth factor receptor-bound protein 2 (rat)
def: "A growth factor receptor-bound protein 2 that is encoded in the genome of rat." [OMA:P62994, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ash" RELATED Gene-based [UniProtKB:P62994]
synonym: "Grb2" RELATED Gene-based [UniProtKB:P62994]
synonym: "rGRB2" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Ash (rat)" EXACT [UniProtKB:P62994]
synonym: "SH2/SH3 adapter GRB2 (rat)" EXACT [UniProtKB:P62994]
synonym: "adapter protein GRB2 (rat)" EXACT [UniProtKB:P62994]
xref: UniProtKB:P62994
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000008224 ! growth factor receptor-bound protein 2
relationship: has_gene_template RGD:619758 ! Grb2 (rat)

[Term]
id: PR:P62994-3
name: growth factor receptor-bound protein 2 isoform r3 (rat)
def: "A growth factor receptor-bound protein 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P62994-3." [PRO:DNx, UniProtKB:P62994]
comment: Category=organism-sequence.
synonym: "rGRB2/iso:r3" EXACT PRO-short-label [PRO:DNx]
synonym: "growth factor receptor-bound protein 2 isoform Ash-S (rat)" EXACT [UniProtKB:P62994]
xref: UniProtKB:P62994-3
is_a: PR:P62994 ! growth factor receptor-bound protein 2 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q60631
name: growth factor receptor-bound protein 2 (mouse)
def: "A growth factor receptor-bound protein 2 that is encoded in the genome of mouse." [OMA:Q60631, PRO:DNx]
comment: Category=organism-gene.
synonym: "Grb2" RELATED Gene-based [UniProtKB:Q60631]
synonym: "mGRB2" EXACT PRO-short-label [PRO:DNx]
synonym: "SH2/SH3 adapter GRB2 (mouse)" EXACT [UniProtKB:Q60631]
synonym: "adapter protein GRB2 (mouse)" EXACT [UniProtKB:Q60631]
xref: UniProtKB:Q60631
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008224 ! growth factor receptor-bound protein 2
relationship: has_gene_template MGI:95805 ! Grb2 (mouse)

[Term]
id: PR:P62994-2
name: growth factor receptor-bound protein 2 isoform r2 (rat)
def: "A growth factor receptor-bound protein 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P62994-2." [PRO:DNx, UniProtKB:P62994]
comment: Category=organism-sequence.
synonym: "rGRB2/iso:r2" EXACT PRO-short-label [PRO:DNx]
synonym: "growth factor receptor-bound protein 2 isoform Ash-M (rat)" EXACT [UniProtKB:P62994]
xref: UniProtKB:P62994-2
is_a: PR:P62994 ! growth factor receptor-bound protein 2 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P29355
name: sex muscle abnormal protein 5 (worm)
def: "A growth factor receptor-bound protein 2 that is encoded in the genome of worm." [OMA:P29355, PRO:DNx]
comment: Category=organism-gene.
synonym: "sem-5" RELATED Gene-based [UniProtKB:P29355]
synonym: "C14F5.5" RELATED Gene-based [UniProtKB:P29355]
synonym: "GRB2 (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P29355
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000008224 ! growth factor receptor-bound protein 2
relationship: has_gene_template WormBase:WBGene00004774 ! sem-5 (worm)

[Term]
id: PR:P62994-1
name: growth factor receptor-bound protein 2 isoform r1 (rat)
def: "A growth factor receptor-bound protein 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P62994-1." [PRO:DNx, UniProtKB:P62994]
comment: Category=organism-sequence.
synonym: "rGRB2/iso:r1" EXACT PRO-short-label [PRO:DNx]
synonym: "growth factor receptor-bound protein 2 isoform Ash-L (rat)" EXACT [UniProtKB:P62994]
xref: UniProtKB:P62994-1
is_a: PR:P62994 ! growth factor receptor-bound protein 2 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000008224
name: growth factor receptor-bound protein 2
def: "A protein that is a translation product of the human GRB2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "ASH" RELATED Gene-based []
synonym: "GRB2" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Ash" EXACT []
synonym: "SH2/SH3 adapter GRB2" EXACT []
synonym: "adapter protein GRB2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P62993-1
name: growth factor receptor-bound protein 2 isoform 1 (human)
def: "A growth factor receptor-bound protein 2 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P62993]
comment: Category=organism-sequence.
synonym: "hGRB2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P62993-1
xref: Reactome:R-HSA-202993 "PR:P62993-1 located_in GO:0005886"
xref: Reactome:R-HSA-74686 "PR:P62993-1 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026787 ! growth factor receptor-bound protein 2 isoform 1

[Term]
id: PR:Q60631-2
name: growth factor receptor-bound protein 2 isoform 2 (mouse)
def: "A growth factor receptor-bound protein 2 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mGRB2/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "growth factor receptor-bound protein 2 isoform GRB3-3 (mouse)" EXACT [UniProtKB:Q60631]
xref: UniProtKB:Q60631-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000040057 ! growth factor receptor-bound protein 2 isoform 2

[Term]
id: PR:Q60631-1
name: growth factor receptor-bound protein 2 isoform 1 (mouse)
def: "A growth factor receptor-bound protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mGRB2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q60631-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000026787 ! growth factor receptor-bound protein 2 isoform 1

[Term]
id: PR:000045847
name: growth factor receptor-bound protein 2 phosphorylated 1 (human)
def: "A growth factor receptor-bound protein 2 (human) that has been phosphorylated at the position equivalent to Tyr-209 of the amino acid sequence represented by UniProtKB:P62993-1. Example: UniProtKB:P62993-1, Tyr-209, MOD:00048." [PMID:11726515, iPTMnet:P62993]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11726515). Status=unreviewed.
synonym: "hGRB2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P62993-1, Tyr-209, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P62993 ! growth factor receptor-bound protein 2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q07883
name: growth factor receptor-bound protein 2 (chicken)
def: "A growth factor receptor-bound protein 2 that is encoded in the genome of chicken." [OMA:Q07883, PRO:DNx]
comment: Category=organism-gene.
synonym: "GRB2" RELATED Gene-based [UniProtKB:Q07883]
synonym: "chick-GRB2" EXACT PRO-short-label [PRO:DNx]
synonym: "SH2/SH3 adapter GRB2 (chicken)" EXACT [UniProtKB:Q07883]
synonym: "adapter protein GRB2 (chicken)" EXACT [UniProtKB:Q07883]
xref: UniProtKB:Q07883
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000008224 ! growth factor receptor-bound protein 2
relationship: has_gene_template NCBIGene:386572 ! GRB2 (chicken)

[Term]
id: PR:P62993-2
name: growth factor receptor-bound protein 2 isoform 2 (human)
def: "A growth factor receptor-bound protein 2 isoform 2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hGRB2/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "growth factor receptor-bound protein 2 isoform GRB3-3 (human)" EXACT [UniProtKB:P62993]
xref: UniProtKB:P62993-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000040057 ! growth factor receptor-bound protein 2 isoform 2

[Term]
id: PR:Q08012
name: growth factor receptor-bound protein 2 (fruit fly)
def: "A growth factor receptor-bound protein 2 that is encoded in the genome of fruit fly." [OMA:Q08012, PRO:DNx]
comment: Category=organism-gene.
synonym: "drk" RELATED Gene-based [UniProtKB:Q08012]
synonym: "Grb2" RELATED Gene-based [UniProtKB:Q08012]
synonym: "CG6033" RELATED Gene-based [UniProtKB:Q08012]
synonym: "E(sev)2B" RELATED Gene-based [UniProtKB:Q08012]
synonym: "fly-GRB2" EXACT PRO-short-label [PRO:DNx]
synonym: "downstream of receptor kinase (fruit fly)" EXACT [UniProtKB:Q08012]
synonym: "protein enhancer of sevenless 2B (fruit fly)" EXACT [UniProtKB:Q08012]
xref: UniProtKB:Q08012
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000008224 ! growth factor receptor-bound protein 2
relationship: has_gene_template FlyBase:FBgn0004638 ! drk (fruit fly)