[Term]
id: PR:000008038
name: lactoylglutathione lyase
def: "A protein that is a translation product of the human GLO1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "GLO1" EXACT PRO-short-label [PRO:DNx]
synonym: "gloA" RELATED [PRO:DNx]
synonym: "Glx I" RELATED []
synonym: "glyoxalase I" RELATED []
synonym: "aldoketomutase" RELATED []
synonym: "methylglyoxalase" RELATED []
synonym: "ketone-aldehyde mutase" BROAD [PRO:DAN]
synonym: "S-D-lactoylglutathione methylglyoxal lyase" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q04760-1
name: lactoylglutathione lyase isoform 1 (human)
def: "A lactoylglutathione lyase isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hGLO1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q04760-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000040275 ! lactoylglutathione lyase isoform 1

[Term]
id: PR:Q04760
name: lactoylglutathione lyase (human)
def: "A lactoylglutathione lyase that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q04760]
comment: Category=organism-gene.
synonym: "GLO1" RELATED Gene-based [UniProtKB:Q04760]
synonym: "hGLO1" EXACT PRO-short-label [PRO:DNx]
synonym: "Glx I (human)" EXACT [UniProtKB:Q04760]
synonym: "glyoxalase I (human)" EXACT [UniProtKB:Q04760]
synonym: "aldoketomutase (human)" EXACT [UniProtKB:Q04760]
synonym: "methylglyoxalase (human)" EXACT [UniProtKB:Q04760]
synonym: "ketone-aldehyde mutase (human)" EXACT [UniProtKB:Q04760]
synonym: "S-D-lactoylglutathione methylglyoxal lyase (human)" EXACT [UniProtKB:Q04760]
xref: UniProtKB:Q04760
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008038 ! lactoylglutathione lyase
relationship: has_gene_template HGNC:4323 ! GLO1 (human)

[Term]
id: PR:Q04760-2
name: lactoylglutathione lyase isoform h2 (human)
def: "A lactoylglutathione lyase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04760-2." [PRO:DNx, UniProtKB:Q04760]
comment: Category=organism-sequence.
synonym: "hGLO1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q04760-2
is_a: PR:Q04760 ! lactoylglutathione lyase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047552
name: lactoylglutathione lyase, initiator methionine removed form (human)
def: "A lactoylglutathione lyase (human) that has had the initiator methionine removed. UniProtKB:Q04760, 2-184." [PRO:DNx, Reactome:R-HSA-5694127]
comment: Category=organism-modification.
synonym: "PRO_0000168076" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hGLO1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q04760, 2-184" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5694127 "PR:000047552 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q04760 ! lactoylglutathione lyase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens