[Term]
id: PR:P30793-4
name: GTP cyclohydrolase 1 isoform hGCH-4 (human)
def: "A GTP cyclohydrolase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30793-4." [PRO:DNx, UniProtKB:P30793]
comment: Category=organism-sequence.
synonym: "hGCH1/iso:hGCH-4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P30793-4
is_a: PR:P30793 ! GTP cyclohydrolase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000040290
name: GTP cyclohydrolase 1 isoform 1
def: "A GTP cyclohydrolase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05915-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "GCH1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000007893 ! GTP cyclohydrolase 1

[Term]
id: PR:P22288
name: GTP cyclohydrolase 1 (rat)
def: "A GTP cyclohydrolase 1 that is encoded in the genome of rat." [OMA:P22288, PANTHER:PTHR11109:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Gch" RELATED Gene-based [UniProtKB:P22288]
synonym: "Gch1" RELATED Gene-based [UniProtKB:P22288]
synonym: "rGCH1" EXACT PRO-short-label [PRO:DNx]
synonym: "GTP-CH-I (rat)" EXACT [UniProtKB:P22288]
synonym: "GTP cyclohydrolase I (rat)" EXACT [UniProtKB:P22288]
xref: UniProtKB:P22288
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000007893 ! GTP cyclohydrolase 1
relationship: has_gene_template RGD:61992 ! Gch1 (rat)

[Term]
id: PR:P50141
name: GTP cyclohydrolase 1 (chicken)
def: "A GTP cyclohydrolase 1 that is encoded in the genome of chicken." [OMA:P50141, PANTHER:PTHR11109:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "GCH1" RELATED Gene-based [UniProtKB:P50141]
synonym: "chick-GCH1" EXACT PRO-short-label [PRO:DNx]
synonym: "GTP-CH-I (chicken)" EXACT [UniProtKB:P50141]
synonym: "GTP cyclohydrolase I (chicken)" EXACT [UniProtKB:P50141]
xref: UniProtKB:P50141
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000007893 ! GTP cyclohydrolase 1
relationship: has_gene_template NCBIGene:396146 ! GCH1 (chicken)

[Term]
id: PR:P30793-1
name: GTP cyclohydrolase 1 isoform hGCH-1 (human)
def: "A GTP cyclohydrolase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30793-1." [PRO:DNx, UniProtKB:P30793]
comment: Category=organism-sequence.
synonym: "hGCH1/iso:hGCH-1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P30793-1
is_a: PR:P30793 ! GTP cyclohydrolase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P30793-2
name: GTP cyclohydrolase 1 isoform hGCH-2 (human)
def: "A GTP cyclohydrolase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30793-2." [PRO:DNx, UniProtKB:P30793]
comment: Category=organism-sequence.
synonym: "hGCH1/iso:hGCH-2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P30793-2
is_a: PR:P30793 ! GTP cyclohydrolase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P30793
name: GTP cyclohydrolase 1 (human)
def: "A GTP cyclohydrolase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P30793]
comment: Category=organism-gene.
synonym: "GCH" RELATED Gene-based [UniProtKB:P30793]
synonym: "DYT5" RELATED Gene-based [UniProtKB:P30793]
synonym: "GCH1" RELATED Gene-based [UniProtKB:P30793]
synonym: "hGCH1" EXACT PRO-short-label [PRO:DNx]
synonym: "GTP-CH-I (human)" EXACT [UniProtKB:P30793]
synonym: "GTP cyclohydrolase I (human)" EXACT [UniProtKB:P30793]
xref: Reactome:R-HSA-1474127 "PR:P30793 located_in GO:0005829"
xref: UniProtKB:P30793
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007893 ! GTP cyclohydrolase 1
relationship: has_gene_template HGNC:4193 ! GCH1 (human)

[Term]
id: PR:P48596-1
name: GTP cyclohydrolase 1 isoform A (fruit fly)
def: "A GTP cyclohydrolase 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48596-1." [PRO:DNx, UniProtKB:P48596]
comment: Category=organism-sequence.
synonym: "fly-GCH1/iso:A" EXACT PRO-short-label [PRO:DNx]
synonym: "GTP cyclohydrolase 1 isoform C (fruit fly)" BROAD [UniProtKB:P48596]
xref: UniProtKB:P48596-1
is_a: PR:P48596 ! GTP cyclohydrolase 1 (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:O13774
name: GTP cyclohydrolase 1 (Schizosaccharomyces pombe 972h-)
def: "A GTP cyclohydrolase 1 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O13774, PRO:DNx]
comment: Category=organism-gene.
synonym: "SPAC17A5.13" RELATED Gene-based [UniProtKB:O13774]
synonym: "Spom972h-GCH1" EXACT PRO-short-label [PRO:DNx]
synonym: "GTP-CH-I (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:O13774]
synonym: "GTP cyclohydrolase I (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:O13774]
xref: UniProtKB:O13774
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000007893 ! GTP cyclohydrolase 1
relationship: has_gene_template PomBase:SPAC17A5.13 ! SPAC17A5.13 (Schizosaccharomyces pombe)

[Term]
id: PR:P30793-3
name: GTP cyclohydrolase 1 isoform hGCH-3 (human)
def: "A GTP cyclohydrolase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30793-3." [PRO:DNx, UniProtKB:P30793]
comment: Category=organism-sequence.
synonym: "hGCH1/iso:hGCH-3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P30793-3
is_a: PR:P30793 ! GTP cyclohydrolase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045748
name: GTP cyclohydrolase 1 phosphorylated 1 (human)
def: "A GTP cyclohydrolase 1 (human) that has been phosphorylated at the position equivalent to Ser-81 of the amino acid sequence represented by UniProtKB:P30793-1. Example: UniProtKB:P30793-1, Ser-81, MOD:00046." [PMID:17704208, iPTMnet:P30793]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:17704208). Status=unreviewed.
synonym: "hGCH1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P30793-1, Ser-81, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P30793 ! GTP cyclohydrolase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P48596-3
name: GTP cyclohydrolase 1 isoform C (fruit fly)
def: "A GTP cyclohydrolase 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48596-3." [PRO:DNx, UniProtKB:P48596]
comment: Category=organism-sequence.
synonym: "fly-GCH1/iso:C" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P48596-3
is_a: PR:P48596 ! GTP cyclohydrolase 1 (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:P22288-1
name: GTP cyclohydrolase 1 isoform 1 (rat)
def: "A GTP cyclohydrolase 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rGCH1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22288-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000040290 ! GTP cyclohydrolase 1 isoform 1

[Term]
id: PR:P48596-2
name: GTP cyclohydrolase 1 isoform B (fruit fly)
def: "A GTP cyclohydrolase 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48596-2." [PRO:DNx, UniProtKB:P48596]
comment: Category=organism-sequence.
synonym: "fly-GCH1/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P48596-2
is_a: PR:P48596 ! GTP cyclohydrolase 1 (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:Q19980
name: GTP cyclohydrolase 1 (worm)
def: "A GTP cyclohydrolase 1 that is encoded in the genome of worm." [PRO:DNx]
comment: Category=organism-gene.
synonym: "cat-4" RELATED Gene-based [UniProtKB:Q19980]
synonym: "F32G8.6" RELATED Gene-based [UniProtKB:Q19980]
synonym: "GCH1 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "GTP-CH-I (worm)" EXACT [UniProtKB:Q19980]
synonym: "GTP cyclohydrolase I (worm)" EXACT [UniProtKB:Q19980]
xref: UniProtKB:Q19980
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000007893 ! GTP cyclohydrolase 1
relationship: has_gene_template WormBase:WBGene00000298 ! cat-4 (worm)

[Term]
id: PR:Q05915-1
name: GTP cyclohydrolase 1 isoform 1 (mouse)
def: "A GTP cyclohydrolase 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mGCH1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05915-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000040290 ! GTP cyclohydrolase 1 isoform 1

[Term]
id: PR:Q05915
name: GTP cyclohydrolase 1 (mouse)
def: "A GTP cyclohydrolase 1 that is encoded in the genome of mouse." [OMA:Q05915, PRO:DNx]
comment: Category=organism-gene.
synonym: "Gch" RELATED Gene-based [UniProtKB:Q05915]
synonym: "Gch1" RELATED Gene-based [UniProtKB:Q05915]
synonym: "mGCH1" EXACT PRO-short-label [PRO:DNx]
synonym: "GTP-CH-I (mouse)" EXACT [UniProtKB:Q05915]
synonym: "GTP cyclohydrolase I (mouse)" EXACT [UniProtKB:Q05915]
xref: UniProtKB:Q05915
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000007893 ! GTP cyclohydrolase 1
relationship: has_gene_template MGI:95675 ! Gch1 (mouse)

[Term]
id: PR:000007893
name: GTP cyclohydrolase 1
def: "A protein that is a translation product of the human GCH1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "GCH" RELATED Gene-based []
synonym: "DYT5" RELATED Gene-based []
synonym: "GCH1" EXACT PRO-short-label [PRO:DNx]
synonym: "GTP-CH-I" BROAD [PRO:DNx]
synonym: "GTP cyclohydrolase I" BROAD [PRO:DNx]
is_a: PR:000000001 ! protein

[Term]
id: PR:P51601
name: GTP cyclohydrolase 1 (yeast)
def: "A GTP cyclohydrolase 1 that is encoded in the genome of yeast." [OMA:P51601, PRO:DNx]
comment: Category=organism-gene.
synonym: "FOL2" RELATED Gene-based [UniProtKB:P51601]
synonym: "G9349" RELATED Gene-based [UniProtKB:P51601]
synonym: "yGCH1" EXACT PRO-short-label [PRO:DNx]
synonym: "YGR267C" RELATED Gene-based [UniProtKB:P51601]
synonym: "GTP-CH-I (yeast)" EXACT [UniProtKB:P51601]
synonym: "GTP cyclohydrolase I (yeast)" EXACT [UniProtKB:P51601]
xref: UniProtKB:P51601
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000007893 ! GTP cyclohydrolase 1
relationship: has_gene_template SGD:S000003499 ! FOL2 (yeast)

[Term]
id: PR:Q94465
name: GTP cyclohydrolase 1 (Dictyostelium discoideum)
def: "A GTP cyclohydrolase 1 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q94465, PRO:DNx]
comment: Category=organism-gene.
synonym: "folE" RELATED Gene-based [UniProtKB:Q94465]
synonym: "gchA" RELATED Gene-based [UniProtKB:Q94465]
synonym: "gtoC" RELATED Gene-based [UniProtKB:Q94465]
synonym: "Dicty-GCH1" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0288481" RELATED Gene-based [UniProtKB:Q94465]
synonym: "GTP-CH (Dictyostelium discoideum)" EXACT [UniProtKB:Q94465]
synonym: "GTP-CH-I (Dictyostelium discoideum)" EXACT [UniProtKB:Q94465]
synonym: "GTP cyclohydrolase I (Dictyostelium discoideum)" EXACT [UniProtKB:Q94465]
xref: UniProtKB:Q94465
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000007893 ! GTP cyclohydrolase 1
relationship: has_gene_template dictyBase:DDB_G0288481 ! gchA (Dictyostelium discoideum)

[Term]
id: PR:P48596
name: GTP cyclohydrolase 1 (fruit fly)
def: "A GTP cyclohydrolase 1 that is encoded in the genome of fruit fly." [OMA:P48596, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pu" RELATED Gene-based [UniProtKB:P48596]
synonym: "CG9441" RELATED Gene-based [UniProtKB:P48596]
synonym: "fly-GCH1" EXACT PRO-short-label [PRO:DNx]
synonym: "GTP-CH-I (fruit fly)" EXACT [UniProtKB:P48596]
synonym: "protein punch (fruit fly)" EXACT [UniProtKB:P48596]
synonym: "GTP cyclohydrolase I (fruit fly)" EXACT [UniProtKB:P48596]
xref: UniProtKB:P48596
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000007893 ! GTP cyclohydrolase 1
relationship: has_gene_template FlyBase:FBgn0003162 ! Pu (fruit fly)