[Term]
id: PR:000050773
name: frizzled-6 O-glycosylated 1 (human)
def: "A frizzled-6 (human) that has been O-glycosylated at the residue equivalent to Thr-136 of the amino acid sequence represented by UniProtKB:O60353-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O60353-1, Thr-136, MOD:00005~GNO:G43417UB." [GlyGen:O60353-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hFZD6/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O60353-1, Thr-136, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O60353 ! frizzled-6 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000050772
name: frizzled-6 N-glycosylated 2 (human)
def: "A frizzled-6 (human) that has been N-glycosylated at the residue equivalent to Asn-38 of the amino acid sequence represented by UniProtKB:O60353-1, in which the glycan composition is represented by GlyTouCan:G99679NM. Example: UniProtKB:O60353-1, Asn-38, MOD:00160~GNO:G99679NM." [GlyGen:O60353-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hFZD6/NGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O60353-1, Asn-38, MOD:00160~GNO:G99679NM" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O60353 ! frizzled-6 (human)
relationship: has_part GNO:G99679NM ! G99679NM
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000050771
name: frizzled-6 N-glycosylated 1 (human)
def: "A frizzled-6 (human) that has been N-glycosylated at the residue equivalent to Asn-38 of the amino acid sequence represented by UniProtKB:O60353-1, in which the glycan composition is represented by GlyTouCan:G27947YN. Example: UniProtKB:O60353-1, Asn-38, MOD:00160~GNO:G27947YN." [GlyGen:O60353-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hFZD6/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O60353-1, Asn-38, MOD:00160~GNO:G27947YN" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O60353 ! frizzled-6 (human)
relationship: has_part GNO:G27947YN ! G27947YN
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O60353-1
name: frizzled-6 isoform h1 (human)
def: "A frizzled-6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60353-1." [PRO:DNx, UniProtKB:O60353]
comment: Category=organism-sequence.
synonym: "hFZD6/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O60353-1
is_a: PR:O60353 ! frizzled-6 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O60353-2
name: frizzled-6 isoform h2 (human)
def: "A frizzled-6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60353-2." [PRO:DNx, UniProtKB:O60353]
comment: Category=organism-sequence.
synonym: "hFZD6/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O60353-2
is_a: PR:O60353 ! frizzled-6 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000050774
name: frizzled-6 O-glycosylated 2 (human)
def: "A frizzled-6 (human) that has been O-glycosylated at the residue equivalent to Thr-141 of the amino acid sequence represented by UniProtKB:O60353-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O60353-1, Thr-141, MOD:00005~GNO:G43417UB." [GlyGen:O60353-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hFZD6/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O60353-1, Thr-141, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O60353 ! frizzled-6 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047477
name: frizzled-6, signal peptide removed ubiquitinated form (human)
def: "A frizzled-6 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:O60353, 19-706, MOD:01148." [PRO:DNx, Reactome:R-HSA-4641189]
comment: Category=organism-modification.
synonym: "hFZD6/SigPep-/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000012994, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:O60353, 19-706, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4641189 "PR:000047477 located_in GO:0005886"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:O60353 ! frizzled-6 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O60353
name: frizzled-6 (human)
def: "A frizzled-6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O60353]
comment: Category=organism-gene.
synonym: "FZD6" RELATED Gene-based [UniProtKB:O60353]
synonym: "hFz6" EXACT [UniProtKB:O60353]
synonym: "hFZD6" EXACT PRO-short-label [PRO:DNx]
synonym: "Fz-6 (human)" EXACT [UniProtKB:O60353]
xref: DTO:02100108
xref: UniProtKB:O60353
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007722 ! frizzled-6
relationship: has_gene_template HGNC:4044 ! FZD6 (human)

[Term]
id: PR:000007722
name: frizzled-6
def: "A frizzled-like G-protein coupled receptor that is a translation product of the human FZD6 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "Fz6" EXACT []
synonym: "FZD6" EXACT PRO-short-label [PRO:DNx]
synonym: "Fz-6" EXACT []
xref: IUPHARobj:234
is_a: PR:000001315 ! frizzled-like G-protein coupled receptor