[Term]
id: PR:000047449
name: fibroblast growth factor receptor substrate 2, initiator methionine removed phosphorylated 2 (human)
def: "A fibroblast growth factor receptor substrate 2 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at positions 132, 135, 138, 376, 452, 455, 458 and 463 of the amino acid sequence represented by UniProtKB:Q8WU20. UniProtKB:Q8WU20, 2-508, Thr-132/Thr-135/Thr-138/Thr-376/Thr-452/Thr-455/Thr-458/Thr-463, MOD:00047." [PRO:DNx, Reactome:R-HSA-1270462]
comment: Category=organism-modification.
synonym: "hFRS2/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000087344, Thr-132/Thr-135/Thr-138/Thr-376/Thr-452/Thr-455/Thr-458/Thr-463, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q8WU20, 2-508, Thr-132/Thr-135/Thr-138/Thr-376/Thr-452/Thr-455/Thr-458/Thr-463, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1270462 "PR:000047449 located_in GO:0005886"
is_a: PR:Q8WU20 ! fibroblast growth factor receptor substrate 2 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000026579
name: fibroblast growth factor receptor substrate 2 isoform 1, initiator methionine removed form
def: "A fibroblast growth factor receptor substrate 2 isoform 1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "FRS2/iso:1/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:000026207 ! fibroblast growth factor receptor substrate 2 isoform 1

[Term]
id: PR:000026207
name: fibroblast growth factor receptor substrate 2 isoform 1
def: "A fibroblast growth factor receptor substrate 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WU20-1 or a 1:1 ortholog thereof." [PRO:CNx]
comment: Category=sequence.
synonym: "FRS2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000007670 ! fibroblast growth factor receptor substrate 2

[Term]
id: PR:000047448
name: fibroblast growth factor receptor substrate 2, initiator methionine removed form (human)
def: "A fibroblast growth factor receptor substrate 2 (human) that has had the initiator methionine removed. UniProtKB:Q8WU20, 2-508." [PRO:DNx, Reactome:R-HSA-190054]
comment: Category=organism-modification.
synonym: "PRO_0000087344" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hFRS2/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8WU20, 2-508" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-190054 "PR:000047448 located_in GO:0005768"
xref: Reactome:R-HSA-190244 "PR:000047448 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q8WU20 ! fibroblast growth factor receptor substrate 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8WU20
name: fibroblast growth factor receptor substrate 2 (human)
def: "A fibroblast growth factor receptor substrate 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8WU20]
comment: Category=organism-gene.
synonym: "FRS2" RELATED Gene-based [UniProtKB:Q8WU20]
synonym: "hFRS2" EXACT PRO-short-label [PRO:DNx]
synonym: "SNT-1 (human)" EXACT [UniProtKB:Q8WU20]
synonym: "FGFR substrate 2 (human)" EXACT [UniProtKB:Q8WU20]
synonym: "FGFR-signaling adaptor SNT (human)" EXACT [UniProtKB:Q8WU20]
synonym: "Suc1-associated neurotrophic factor target 1 (human)" EXACT [UniProtKB:Q8WU20]
xref: UniProtKB:Q8WU20
xref: Reactome:R-HSA-170963 "PR:Q8WU20 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007670 ! fibroblast growth factor receptor substrate 2
relationship: has_gene_template HGNC:16971 ! FRS2 (human)

[Term]
id: PR:Q8C180
name: fibroblast growth factor receptor substrate 2 (mouse)
def: "A fibroblast growth factor receptor substrate 2 that is encoded in the genome of mouse." [OMA:Q8C180, PRO:DNx]
comment: Category=organism-gene.
synonym: "Frs2" RELATED Gene-based [UniProtKB:Q8C180]
synonym: "Frs2a" RELATED Gene-based [UniProtKB:Q8C180]
synonym: "mFRS2" EXACT PRO-short-label [PRO:DNx]
synonym: "SNT-1 (mouse)" EXACT [UniProtKB:Q8C180]
synonym: "FRS2-alpha (mouse)" EXACT [UniProtKB:Q8C180]
synonym: "FGFR substrate 2 (mouse)" EXACT [UniProtKB:Q8C180]
synonym: "FGFR-signaling adaptor SNT (mouse)" EXACT [UniProtKB:Q8C180]
synonym: "Suc1-associated neurotrophic factor target 1 (mouse)" EXACT [UniProtKB:Q8C180]
xref: UniProtKB:Q8C180
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000007670 ! fibroblast growth factor receptor substrate 2
relationship: has_gene_template MGI:1100860 ! Frs2 (mouse)

[Term]
id: PR:000026209
name: fibroblast growth factor receptor substrate 2, initiator methionine removed phosphorylated 1
def: "A fibroblast growth factor receptor substrate 2, initiator methionine removed form that has been phosphorylated by activated TrkA. FRS2 is an adapter protein that links NGF receptors to downstream signaling pathways. It is involved in the activation of MAP kinases. Example: UniProtKB:Q8WU20-1, Tyr-196/Tyr-306/Tyr-349/Tyr-392/Tyr-436/Tyr-471, MOD:00048." [PRO:CNA, PRO:DAN, Reactome:R-HSA-170959, Reactome:R-HSA-190062]
comment: Category=modification.
synonym: "Phospho-Frs2" RELATED []
synonym: "FRS2/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000019931 ! fibroblast growth factor receptor substrate 2, initiator methionine removed form
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:Q8WU20-1
name: fibroblast growth factor receptor substrate 2 isoform 1 (human)
def: "A fibroblast growth factor receptor substrate 2 isoform 1 that is encoded in the genome of human." [PRO:CNx]
comment: Category=organism-sequence.
synonym: "hFRS2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8WU20-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026207 ! fibroblast growth factor receptor substrate 2 isoform 1

[Term]
id: PR:Q8C180-1
name: fibroblast growth factor receptor substrate 2 isoform 1 (mouse)
def: "A fibroblast growth factor receptor substrate 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNx]
comment: Category=organism-sequence.
synonym: "mFRS2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8C180-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000026207 ! fibroblast growth factor receptor substrate 2 isoform 1

[Term]
id: PR:000026214
name: fibroblast growth factor receptor substrate 2, initiator methionine removed phosphorylated 1 (human)
def: "A fibroblast growth factor receptor substrate 2, initiator methionine removed phosphorylated 1 in human. UniProtKB:Q8WU20, 2-508, Tyr-196/Tyr-306/Tyr-349/Tyr-392/Tyr-436/Tyr-471, MOD:00048." [PRO:CNx, PRO:DAN, Reactome:R-HSA-170959, Reactome:R-HSA-190062]
comment: Category=organism-modification.
synonym: "hFRS2/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000087344, Tyr-196/Tyr-306/Tyr-349/Tyr-392/Tyr-436/Tyr-471, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q8WU20, 2-508, Tyr-196/Tyr-306/Tyr-349/Tyr-392/Tyr-436/Tyr-471, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-190062 "PR:000026214 located_in GO:0005768"
xref: Reactome:R-HSA-190355 "PR:000026214 located_in GO:0005829"
xref: Reactome:R-HSA-170959 "PR:000026214 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026209 ! fibroblast growth factor receptor substrate 2, initiator methionine removed phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000007670
name: fibroblast growth factor receptor substrate 2
def: "A protein that is a translation product of the human FRS2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "FRS2" EXACT PRO-short-label [PRO:DNx]
synonym: "Frs2a" RELATED Gene-based []
synonym: "SNT-1" EXACT []
synonym: "FRS2-alpha" EXACT []
synonym: "FGFR substrate 2" EXACT []
synonym: "FGFR-signaling adaptor SNT" EXACT []
synonym: "suc1-associated neurotrophic factor target 1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000019931
name: fibroblast growth factor receptor substrate 2, initiator methionine removed form
def: "A fibroblast growth factor receptor substrate 2 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "FRS2/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000007670 ! fibroblast growth factor receptor substrate 2
intersection_of: lacks_part PR:000021937 ! initiator methionine