[Term]
id: PR:G3V7R4
name: forkhead box protein O1 (rat)
def: "A forkhead box protein O1 that is encoded in the genome of rat." [OMA:G3V7R4, PRO:DNx]
comment: Category=organism-gene.
synonym: "Foxo1" RELATED Gene-based [UniProtKB:G3V7R4]
synonym: "Foxo1a" RELATED Gene-based [UniProtKB:G3V7R4]
synonym: "rFOXO1" EXACT PRO-short-label [PRO:DNx]
synonym: "forkhead box protein O1A (rat)" EXACT [UniProtKB:G3V7R4]
synonym: "forkhead in rhabdomyosarcoma (rat)" EXACT [UniProtKB:G3V7R4]
xref: UniProtKB:G3V7R4
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000007640 ! forkhead box protein O1
relationship: has_gene_template RGD:620283 ! Foxo1 (rat)

[Term]
id: PR:Q9R1E0
name: forkhead box protein O1 (mouse)
def: "A forkhead box protein O1 that is encoded in the genome of mouse." [OMA:Q9R1E0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Fkhr" RELATED Gene-based [UniProtKB:Q9R1E0]
synonym: "Foxo1" RELATED Gene-based [UniProtKB:Q9R1E0]
synonym: "Foxo1a" RELATED Gene-based [UniProtKB:Q9R1E0]
synonym: "mFOXO1" EXACT PRO-short-label [PRO:DNx]
synonym: "forkhead box protein O1A (mouse)" EXACT [UniProtKB:Q9R1E0]
synonym: "forkhead in rhabdomyosarcoma (mouse)" EXACT [UniProtKB:Q9R1E0]
xref: UniProtKB:Q9R1E0
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000007640 ! forkhead box protein O1
relationship: has_gene_template MGI:1890077 ! Foxo1 (mouse)

[Term]
id: PR:000027893
name: forkhead box protein O1 isoform 1 phosphorylated 1
def: "A forkhead box protein O1 isoform 1 that has been modified on a conserved Ser residue in the GKSPRRR motif at the C-terminus of the Forkhead box DNA-binding domain.This modification promotes FOXO1 activation and cell death in neurons. Example: UniProtKB:Q12778, Ser-249, MOD:00046." [PMID:18356527, PRO:PD]
comment: Category=modification.
synonym: "FOXO1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027868 ! forkhead box protein O1 isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027894
name: forkhead box protein O1 isoform 1 phosphorylated 1 (human)
def: "A forkhead box protein O1 isoform 1 phosphorylated 1 in human. UniProtKB:Q12778-1, Ser-249, MOD:00046." [PMID:18356527, PRO:PD]
comment: Category=organism-modification. Kinase=("CDK1"; PR:P06493; Ser-249).
synonym: "FOXO1-pSer249" EXACT []
synonym: "hFOXO1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q12778-1, Ser-249, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027893 ! forkhead box protein O1 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027895
name: forkhead box protein O1 phosphorylated 2
def: "A forkhead box protein O1 that has been modified at one Thr and two Ser residues, all situated within the canonical AKT1 kinase consensus RXRXX(S/T) motifs. Example: UniProtKB:Q12778, Thr-24, MOD:00047|Ser-256/Ser-319, MOD:00046." [PMID:10358075, PRO:PD]
comment: Category=modification.
synonym: "FOXO1/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000007640 ! forkhead box protein O1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027896
name: forkhead box protein O1 phosphorylated 2 (human)
def: "A forkhead box protein O1 phosphorylated 2 in human. UniProtKB:Q12778, Thr-24, MOD:00047|Ser-256/Ser-319, MOD:00046." [PMID:10358075, PRO:PD]
comment: Category=organism-modification. Kinase=("AKT1"; PR:P31749).
synonym: "hFOXO1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "FOXO1-pThr24-pSer256-pSer319" EXACT []
synonym: "UniProtKB:Q12778, Thr-24, MOD:00047|Ser-256/Ser-319, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-211158 "PR:000027896 located_in GO:0005829"
xref: Reactome:R-HSA-199306 "PR:000027896 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027895 ! forkhead box protein O1 phosphorylated 2
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027868
name: forkhead box protein O1 isoform 1
def: "A forkhead box protein O1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12778-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "FOXO1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000007640 ! forkhead box protein O1

[Term]
id: PR:Q9R1E0-1
name: forkhead box protein O1 isoform 1 (mouse)
def: "A forkhead box protein O1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mFOXO1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9R1E0-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000027868 ! forkhead box protein O1 isoform 1

[Term]
id: PR:Q12778
name: forkhead box protein O1 (human)
def: "A forkhead box protein O1 that is encoded in the genome of human." [PRO:PD]
comment: Category=organism-gene.
synonym: "FKHR" RELATED Gene-based [UniProtKB:Q12778]
synonym: "FOXO1" RELATED Gene-based [UniProtKB:Q12778]
synonym: "FOXO1A" RELATED Gene-based [UniProtKB:Q12778]
synonym: "hFOXO1" EXACT PRO-short-label [PRO:DNx]
synonym: "forkhead box protein O1A (human)" EXACT [UniProtKB:Q12778]
synonym: "forkhead in rhabdomyosarcoma (human)" EXACT [UniProtKB:Q12778]
xref: UniProtKB:Q12778
xref: Reactome:R-HSA-199300 "PR:Q12778 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007640 ! forkhead box protein O1
relationship: has_gene_template HGNC:3819 ! FOXO1 (human)

[Term]
id: PR:Q12778-1
name: forkhead box protein O1 isoform 1 (human)
def: "A forkhead box protein O1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hFOXO1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q12778-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027868 ! forkhead box protein O1 isoform 1

[Term]
id: PR:A3RK74
name: forkhead box protein O1-A (zebrafish)
def: "A forkhead box protein O1 that is encoded in the genome of zebrafish." [OMA:A3RK74, PRO:DNx]
comment: Category=organism-gene.
synonym: "foxo1" RELATED Gene-based [UniProtKB:A3RK74]
synonym: "foxo1a" RELATED Gene-based [UniProtKB:A3RK74]
synonym: "z-FOXO1" EXACT PRO-short-label [PRO:DNx]
synonym: "foxO1a.1" RELATED Gene-based [UniProtKB:A3RK74]
xref: UniProtKB:A3RK74
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000007640 ! forkhead box protein O1
relationship: has_gene_template ZFIN:ZDB-GENE-061013-59 ! foxo1a (zebrafish)

[Term]
id: PR:000045892
name: forkhead box protein O1 phosphorylated 1 (human)
def: "A forkhead box protein O1 (human) that has been phosphorylated at Ser-212. UniProtKB:Q12778, Ser-212, MOD:00046." [PMID:19221179, iPTMnet:Q12778]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:19221179). Status=unreviewed.
synonym: "hFOXO1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q12778, Ser-212, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q12778 ! forkhead box protein O1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047446
name: forkhead box protein O1 phosphorylated 3 (human)
def: "A forkhead box protein O1 (human) that has been post-translationally modified to include phosphoserine at position 218 of the amino acid sequence represented by UniProtKB:Q12778. UniProtKB:Q12778, Ser-218, MOD:00046." [PRO:DAN, Reactome:R-HSA-5692651]
comment: Category=organism-modification. Note: The modified site indicated here (Ser-218) is referred to as Ser-215 in the literature using the mouse sequence. [PRO:DAN, PMID:23878308]
synonym: "hFOXO1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q12778, Ser-218, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-5692651 "PR:000047446 located_in GO:0005654"
is_a: PR:Q12778 ! forkhead box protein O1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000007640
name: forkhead box protein O1
def: "A protein that is a translation product of the human FOXO1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "FKHR" RELATED Gene-based []
synonym: "FOXO1" EXACT PRO-short-label [PRO:DNx]
synonym: "FOXO1A" RELATED Gene-based []
synonym: "forkhead box protein O1A" EXACT []
synonym: "forkhead in rhabdomyosarcoma" EXACT []
is_a: PR:000000001 ! protein