[Term]
id: PR:P22830
name: ferrochelatase, mitochondrial (human)
def: "A ferrochelatase, mitochondrial that is encoded in the genome of human." [PRO:DNx, UniProtKB:P22830]
comment: Category=organism-gene.
synonym: "FECH" RELATED Gene-based [UniProtKB:P22830]
synonym: "hFECH" EXACT PRO-short-label [PRO:DNx]
synonym: "heme synthase (human)" EXACT [UniProtKB:P22830]
synonym: "protoheme ferro-lyase (human)" EXACT [UniProtKB:P22830]
xref: UniProtKB:P22830
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007453 ! ferrochelatase, mitochondrial
relationship: has_gene_template HGNC:3647 ! FECH (human)

[Term]
id: PR:Q9V9S8-1
name: ferrochelatase, mitochondrial isoform A (fruit fly)
def: "A ferrochelatase, mitochondrial (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9V9S8-1." [PRO:DNx, UniProtKB:Q9V9S8]
comment: Category=organism-sequence.
synonym: "fly-FECH/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9V9S8-1
is_a: PR:Q9V9S8 ! ferrochelatase, mitochondrial (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:Q9V9S8-2
name: ferrochelatase, mitochondrial isoform B (fruit fly)
def: "A ferrochelatase, mitochondrial (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9V9S8-2." [PRO:DNx, UniProtKB:Q9V9S8]
comment: Category=organism-sequence.
synonym: "fly-FECH/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9V9S8-2
is_a: PR:Q9V9S8 ! ferrochelatase, mitochondrial (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:Q9V9S8-3
name: ferrochelatase, mitochondrial isoform C (fruit fly)
def: "A ferrochelatase, mitochondrial (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9V9S8-3." [PRO:DNx, UniProtKB:Q9V9S8]
comment: Category=organism-sequence.
synonym: "fly-FECH/iso:C" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9V9S8-3
is_a: PR:Q9V9S8 ! ferrochelatase, mitochondrial (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:Q9V9S8
name: ferrochelatase, mitochondrial (fruit fly)
def: "A ferrochelatase, mitochondrial that is encoded in the genome of fruit fly." [OMA:Q9V9S8, PANTHER:PTHR11108:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "FeCH" RELATED Gene-based [UniProtKB:Q9V9S8]
synonym: "FeCh" RELATED Gene-based [UniProtKB:Q9V9S8]
synonym: "CG2098" RELATED Gene-based [UniProtKB:Q9V9S8]
synonym: "fly-FECH" EXACT PRO-short-label [PRO:DNx]
synonym: "heme synthase (fruit fly)" EXACT [UniProtKB:Q9V9S8]
synonym: "protoheme ferro-lyase (fruit fly)" EXACT [UniProtKB:Q9V9S8]
xref: UniProtKB:Q9V9S8
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000007453 ! ferrochelatase, mitochondrial
relationship: has_gene_template FlyBase:FBgn0266268 ! FeCH (fruit fly)

[Term]
id: PR:O42479
name: ferrochelatase, mitochondrial (chicken)
def: "A ferrochelatase, mitochondrial that is encoded in the genome of chicken." [OMA:O42479, PANTHER:PTHR11108:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "FECH" RELATED Gene-based [UniProtKB:O42479]
synonym: "chick-FECH" EXACT PRO-short-label [PRO:DNx]
synonym: "heme synthase (chicken)" EXACT [UniProtKB:O42479]
synonym: "protoheme ferro-lyase (chicken)" EXACT [UniProtKB:O42479]
xref: UniProtKB:O42479
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000007453 ! ferrochelatase, mitochondrial
relationship: has_gene_template NCBIGene:374020 ! FECH (chicken)

[Term]
id: PR:000047396
name: ferrochelatase, mitochondrial, transit peptide removed form (human)
def: "A ferrochelatase, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P22830, 55-423." [PRO:DNx, Reactome:R-HSA-189441]
comment: Category=organism-modification.
synonym: "PRO_0000008873" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hFECH/TransPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P22830, 55-423" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-189441 "PR:000047396 located_in GO:0005759"
intersection_of: PR:P22830 ! ferrochelatase, mitochondrial (human)
intersection_of: lacks_part SO:0000725 ! transit_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P22315
name: ferrochelatase, mitochondrial (mouse)
def: "A ferrochelatase, mitochondrial that is encoded in the genome of mouse." [OMA:P22315, PRO:DNx]
comment: Category=organism-gene.
synonym: "Fech" RELATED Gene-based [UniProtKB:P22315]
synonym: "mFECH" EXACT PRO-short-label [PRO:DNx]
synonym: "heme synthase (mouse)" EXACT [UniProtKB:P22315]
synonym: "protoheme ferro-lyase (mouse)" EXACT [UniProtKB:P22315]
xref: UniProtKB:P22315
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000007453 ! ferrochelatase, mitochondrial
relationship: has_gene_template MGI:95513 ! Fech (mouse)

[Term]
id: PR:Q54IA8
name: ferrochelatase, mitochondrial (Dictyostelium discoideum)
def: "A ferrochelatase, mitochondrial that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54IA8, PANTHER:PTHR11108:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "hemH" RELATED Gene-based [UniProtKB:Q54IA8]
synonym: "Dicty-FECH" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0288891" RELATED Gene-based [UniProtKB:Q54IA8]
synonym: "heme synthase (Dictyostelium discoideum)" EXACT [UniProtKB:Q54IA8]
synonym: "protoheme ferro-lyase (Dictyostelium discoideum)" EXACT [UniProtKB:Q54IA8]
xref: UniProtKB:Q54IA8
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000007453 ! ferrochelatase, mitochondrial
relationship: has_gene_template dictyBase:DDB_G0288891 ! hemH (Dictyostelium discoideum)

[Term]
id: PR:P42043
name: ferrochelatase-1, chloroplastic/mitochondrial (Arabidopsis thaliana)
def: "A ferrochelatase, mitochondrial that is encoded in the genome of Arabidopsis thaliana." [OMA:P42043, PRO:DNx]
comment: Category=organism-gene.
synonym: "FC1" RELATED Gene-based [UniProtKB:P42043]
synonym: "FC-I" RELATED Gene-based [UniProtKB:P42043]
synonym: "AtFC1" EXACT [UniProtKB:P42043]
synonym: "HEM15" RELATED Gene-based [UniProtKB:P42043]
synonym: "AtFC-I" EXACT [UniProtKB:P42043]
synonym: "At-FECH" EXACT PRO-short-label [PRO:DNx]
synonym: "T1N24.17" RELATED Gene-based [UniProtKB:P42043]
synonym: "At5g26030" RELATED Gene-based [UniProtKB:P42043]
synonym: "heme synthase 1 (Arabidopsis thaliana)" EXACT [UniProtKB:P42043]
synonym: "ferrochelatase-I (Arabidopsis thaliana)" EXACT [UniProtKB:P42043]
synonym: "protoheme ferro-lyase 1 (Arabidopsis thaliana)" EXACT [UniProtKB:P42043]
xref: UniProtKB:P42043
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000007453 ! ferrochelatase, mitochondrial
relationship: has_gene_template Araport:AT5G26030 ! FC1 (Arabidopsis thaliana)

[Term]
id: PR:000007453
name: ferrochelatase, mitochondrial
def: "A protein that is a translation product of the human FECH gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "FECH" EXACT PRO-short-label [PRO:DNx]
synonym: "heme synthase" BROAD [PRO:DNx]
synonym: "protoheme ferro-lyase" BROAD [PRO:DNx]
is_a: PR:000000001 ! protein

[Term]
id: PR:000019872
name: ferrochelatase, mitochondrial, transit peptide removed form
def: "A ferrochelatase, mitochondrial that has had the transit peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "FECH/TransPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000007453 ! ferrochelatase, mitochondrial
intersection_of: lacks_part SO:0000725 ! transit_peptide

[Term]
id: PR:P22830-1
name: ferrochelatase, mitochondrial isoform h1 (human)
def: "A ferrochelatase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22830-1." [PRO:DNx, UniProtKB:P22830]
comment: Category=organism-sequence.
synonym: "hFECH/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22830-1
is_a: PR:P22830 ! ferrochelatase, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P22830-2
name: ferrochelatase, mitochondrial isoform h2 (human)
def: "A ferrochelatase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22830-2." [PRO:DNx, UniProtKB:P22830]
comment: Category=organism-sequence.
synonym: "hFECH/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22830-2
is_a: PR:P22830 ! ferrochelatase, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P16622
name: ferrochelatase, mitochondrial (yeast)
def: "A ferrochelatase, mitochondrial that is encoded in the genome of yeast." [OMA:P16622, PANTHER:PTHR11108:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "HEM15" RELATED Gene-based [UniProtKB:P16622]
synonym: "yFECH" EXACT PRO-short-label [PRO:DNx]
synonym: "YOR176W" RELATED Gene-based [UniProtKB:P16622]
synonym: "heme synthase (yeast)" EXACT [UniProtKB:P16622]
synonym: "protoheme ferro-lyase (yeast)" EXACT [UniProtKB:P16622]
xref: UniProtKB:P16622
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000007453 ! ferrochelatase, mitochondrial
relationship: has_gene_template SGD:S000005702 ! HEM15 (yeast)

[Term]
id: PR:O59786
name: ferrochelatase, mitochondrial (Schizosaccharomyces pombe 972h-)
def: "A ferrochelatase, mitochondrial that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O59786, PANTHER:PTHR11108:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "hem15" RELATED Gene-based [UniProtKB:O59786]
synonym: "SPCC320.09" RELATED Gene-based [UniProtKB:O59786]
synonym: "Spom972h-FECH" EXACT PRO-short-label [PRO:DNx]
synonym: "heme synthase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:O59786]
synonym: "protoheme ferro-lyase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:O59786]
xref: UniProtKB:O59786
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000007453 ! ferrochelatase, mitochondrial
relationship: has_gene_template PomBase:SPCC320.09 ! hem15 (Schizosaccharomyces pombe)